Rivastigmine

When ATH:
N06DA03

Pharmacological action.
Antiholinesteraznae.

Application.

Alytsgeymerovskogo dementia type (mild to moderate severity, when suspected or diagnosed with Alzheimer's disease).

Contraindications.

Hypersensitivity (incl. to karbamoilatinu and other derivatives carbamate), breast-feeding.

Restrictions apply.

Peptic ulcer and duodenal, sick sinus syndrome, arrhythmia, bronchial obstruction, urinary tract obstruction (prostate adenoma), convulsions, zakrыtougolynaya glaucoma.

Pregnancy and breast-feeding.

When pregnancy is possible, if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Side effects.

From the nervous system and sensory organs: fatigue, asthenia, dizziness, headache, drowsiness, excitation, insomnia, disorientation, depression, tremor.

From the digestive tract: nausea, vomiting, diarrhea, abdominal pain, anorexia, dyspepsia.

Other: allergic reactions, Sweating, weight loss, upper respiratory tract infection and urinary tract.

Cooperation.

Not recommended simultaneous application with other holinomimetikami. It enhances the effect of depolarizing muscle relaxants during anesthesia.

Patients with Alzheimer's simultaneous use of antacids, antiemetic and anti-diabetic agents, antihypertensive medications central action, beta-blockers, calcium channel blockers, digoksina, antianginal drugs, NSAIDs, estrogen, analgesics, benzodiazepines and antihistamines are not accompanied by changes formakokinetiki rivastigmine or an increased risk of side effects. In healthy volunteers showed no pharmacokinetic interaction with digoxin, varfarinom, diazepam and fluoxetine.

Overdose.

Symptoms: nausea, vomiting, diarrhea.

Treatment: отмена лечения на 24 no, the use of antiemetics, atropine sulfate (при значительной передозировке в начальной дозе 0,03 мг/ кг в/в), simptomaticheskaya therapy. We do not recommend the use of scopolamine as an antidote.

Dosing and Administration.

Inside, while eating. Начальная доза — по 1,5 mg 2 once a day (при повышенной чувствительности к холинергических средствам — по 1 mg 2 once a day). With good endurance through 2 нед возможно повышение дозы до 3 mg 2 times a day at intervals of more 2 Sun to 4,5 and 6 mg / day. Поддерживающая доза составляет 1,5–6 мг 2 once a day. The maximum daily dose - 12 mg / day. To achieve the best therapeutic effect is maintained at a maximum dose of good endurance level.

Precautions.

Cholinergic stimulation can enhance the secretion of hydrochloric acid in the stomach.

Side effects, observed during treatment, may decrease in the admission after skipping one or more doses of the drug. If side effects persist, the daily dose should be lowered to the previous, well tolerated the patient level. If the kidney function or liver dose adjustment is required.