Rilmenidine

When ATH:
C02AC06

Characteristic.

It is soluble in water and methanol, slightly soluble in ethyl alcohol.

Pharmacological action.
Antigipertenzivnoe.

Application.

Arterial hypertension.

Contraindications.

Hypersensitivity, severe depression, severe renal insufficiency (Cl creatinine less than 15 ml / min), Pregnancy and breast-feeding, childhood (not enough clinical experience).

Pregnancy and breast-feeding.

Contraindicated during pregnancy, Although in animal experiments was observed embryotoxic or teratogenic effects. At the time of treatment should stop breastfeeding (It passes into breast milk).

Side effects.

From the nervous system and sensory organs: drowsiness or insomnia, asthenia, dizziness, weakness during exercise; a sense of fear, depression, convulsions.

Cardio-vascular system and blood: heartbeat, cold extremities, orthostatic hypotension, tides.

From the digestive tract: dry mouth, epigastric pain, diarrhea, nausea, constipation.

With the genitourinary system: peripheral edema, disorders of sexual function.

For the skin: skin rashes, itch.

Cooperation.

Effect increase vasodilators, diuretics and antihistamines, weaken-tricyclic antidepressants. Not recommended simultaneous application with MAO inhibitors.

Overdose.

Symptoms: severe hypotension, mental disorder, disturbance of consciousness.

Treatment: gastric lavage, administration of sympathomimetic agents. Hemodialysis maloeffyektivyen.

Dosing and Administration.

Inside. The recommended dose - 1 mg/day in the morning. If after reception within 1 Months normalization of blood pressure is not reached, the dose can be increased to 2 mg / day (by 1 mg morning and evening during mealtimes). Treatment is ongoing and long-term. If you cancel, reduce the dose gradually.

Precautions.

Need for extreme caution in patients with sinus bradycardia (HR less 50 u. / min), sick sinus syndrome, AV blockade II-III degree and severe liver disease. In therapeutic doses does not affect the focus and the ability to concentrate. Exceeding the recommended dose or the simultaneous administration of these drugs, CNS depressants, may cause drowsiness (should be considered when assigning people, professional activities that require rapid mental and physical reactions). The treatment should be deleted alcohol.