Riboflavin – Riboflavin

When ATH: A11HA04

Pharmacological action

Витамин B2. It supports the process of phagocytosis, effect on the morphology and function of the central and autonomic nervous systems, plays an important role in maintaining the normal visual function of the eyes and in the synthesis of erythropoietin, Hemoglobin. Several increases the secretory function of the stomach (involved in the formation of hydrochloric acid of the gastric juice), improves biliary excretion, It facilitates the absorption of carbohydrates in the small intestine, is required to maintain the normal intestinal microflora. It helps improve glikogenofiksiruyuschey, synthetic, antitoxic function of the liver, It increases the sensitivity of cells to hepatic insulin action, promotes insulin incretion. It normalizes the levels of bilirubin in the blood (hepatitis A).

Pharmacokinetics

Riboflavin and its nucleotides are rapidly absorbed from the gastrointestinal tract. Chronic gastritis, enteritis, Akhil delay absorption. Unevenly distributed in the organs and tissues of the body: most – myocardial, liver, kidney. Plasma protein binding – 60%. It penetrates through the placental barrier, excreted in breast milk. Report the news.

Testimony

Hypo- и авитаминоз B2, day-blindness, conjunctivitis, keratit, Irit, helcoma, Cataract, nonhealing wounds and ulcers, common eating disorders, radiation sickness, asthenia, intestinal problems, hepatitis.

Dosage regimen

Inside - 5-10 mg (Children - 2-5 mg) 13 times a day for 1-1.5 months. Daily dose - up 50 mg.

V / m - 1 ml 1% solution 1 once a day for 10-15 days (Children - 3-5 days), then 2-3 times a week, total - 15-20 injections. In diseases of the eye - of 0.2-0.5 ml 1% solution for 10-15 days.

Side effect

Maybe: allergic reactions, impairment of renal function, blurred vision.

Contraindications

Hypersensitivity to riboflavin, nephrolithiasis.

Pregnancy and breast-feeding

Perhaps the use of riboflavin during pregnancy and lactation (breast-feeding) on indications.

Cautions

Urine stains in light yellow color.

Drug Interactions

While the use of m-holinoblokatorami increased absorption and bioavailability of riboflavin (by reducing intestinal peristalsis).

While the use of thyroid hormone accelerates metabolism of riboflavin.

With simultaneous application of decreasing the activity of doxycycline, tetracycline, oxytetracycline, erythromycin and lincomycin.

Riboflavin nesovmestim with streptomicinom.

With simultaneous use of reduced side effects and warning chloramphenicol (violation of hematopoiesis, optic neuritis).

With simultaneous application of chlorpromazine, amitriptyline due to blockade flavinokinazy violate flavinadeninmononukleotid including riboflavin and flavin adenine dinucleotide and increase its excretion in the urine.