Rhubarb Tangut – Rheum tangutic Maxim

Perennial herbaceous plant 1-1.5 m, families grechishnыh (Polygonaceae). Widely cultivated as a medicinal, ornamental and food plants. For medical purposes, harvest the roots and rhizomes.

Rhubarb Tangut – chemical composition

Rhubarb Tangut contains antraglikozidy and tanoglikozidy, as well as their availability aglucone (reumémodin, xrizofanol, rhein et al.), hrizofanovuyu acid, resinous substances and pigments. Antraglikozidy are ether-like compounds, which, after cleavage of the sugar to form emodin and other derivatives of anthracene.

Rhubarb Tangut – Pharmacological properties

Tanoglikozidy have astringent, antidiarrheal and antiseptic properties. Antraglikozidy, opposite, have a laxative effect, increases peristalsis. The laxative effect occurs within 8-10 hours after ingestion and is mainly due to emodine, rhein and hrizofanovoy acid, that, interoreceptors irritating the mucous membrane of the colon, cause increased peristalsis and more rapid passage of stool.

In small doses of drugs rhubarb astringent action, due tanoglikozidami. In large doses, rhubarb gives a laxative effect, due to the action of antraglikozidov. Laxative and astringent rhubarb depends not only on the dose, but also the solubility of the compounds. Aqueous extracts of rhubarb contain more tannin, than antraglikozidov, and alcohol extraction is somewhat richer antraglikozidy. Besides, herbal form of the plant increase bile. At high doses, all herbal medicines rhubarb cause local irritation of the large intestine and, therefore, increase blood flow to the pelvic organs, which is especially dangerous during pregnancy.

Because of the reduction products hrizofanovoy acid and emodin obtained drug Chrysarobin. At low concentrations of this drug vasoconstrictor properties and gives a pronounced anti-inflammatory and keratolytic effect, at higher concentrations it may even cause dermatitis. Extracted from plants Chrysarobin hitherto widely used in dermatological practice.

Rhubarb Tangut – medical applications

Rhubarb is used as a laxative and choleretic agent in chronic constipation. When using drugs rhubarb patients due to irritation of the mucous membrane receptors colon reflex intensifies peristalsis. Contained in rhubarb roots antraglikozidy peristalsis of the stomach and small intestine almost no effect. In medical practice, drugs rhubarb is usually prescribed for mild and gradual laxative effect in intestinal atony, flatulence and chronic constipation. Assign mainly patients in the elderly and children.

Drugs used in powders rhubarb, pills, broth alone and in combination with other substances as laxatives. Sometimes drugs rhubarb take in small doses (0,050.2 g) as binders, reduce peristalsis. Their astringent effect associated with tanoglikozidami, that, binding proteins, precipitated their, forming a precipitate, receptors protects the intestinal mucosa.

In high doses, the drug can cause vomiting rhubarb, diarrhea, colicky abdominal pain, tenesmus, increased rush of blood to the pelvic organs. To avoid this, laxative dose picked individually. Prolonged uncontrolled use of laxatives can contribute to the development of chronic inflammation in the intestinal mucosa. Besides, possibly addictive laxative plants, and its effectiveness over time, can significantly decrease, forcing patients to increase the dose of medication.

Contraindications to the use of rhubarb: acute appendicitis and cholecystitis (danger of perforation), ostrыy peritonitis, the presence of mechanical obstruction to promote intestinal contents (obstruction, infringement of the intestine) , bleeding from the gastrointestinal tract, pregnancy, since laxatives reflexively increase uterine contractions.

Rhubarb Tangut – Dosage Forms, Dosing and Administration

Tablets rhubarb have a yellow-brown color. Comprise 0,3 or 0,5 g of finely powdered rhubarb root. Apply for constipation 1-2 tablets at reception, usually at night after meals.

Rhubarb extract dry water-alcoholic extract. It is a coarse powder of yellowish-brown, peculiar smell, bitter taste. The dosage depends on the age - from 0,1 1-2 g per reception.

Tincture bitter rhubarb prepared from rhizomes and roots of rhubarb, gentian root powder, rhizome powder and alcohol 70 %. Transparent liquid reddish-brown or red, slaboaromatnogo peculiar smell, bitter taste. Take 1 / 2-1 teaspoon 2 times a day before meals during intestinal atony, meteorism, chronic constipation.

Syrup of rhubarb It contains dry extract of rhubarb 1,25 parts, alcohol 2 parts, Water dill 3 parts, sugar syrup 94 parts and a brown-red liquid, peculiar smell and taste. It is used mainly in pediatric practice for digestive disorders, accompanied by flatulence and a tendency to constipation. Dose picked individually, usually 1 / 2-1 teaspoon to the reception before the meal 3 once a day.

Preparations rhubarb preserve in a cool, protected from light.