Protionamid

When ATH:
J04AD01

Characteristic.

Tioamid, isonicotinic acid derivative. TB drugs II series. The yellow crystalline material. Practically insoluble in water, slightly soluble in ether and chloroform, soluble in methanol and ethyl. Molecular weight 180,27.

Pharmacological action.
Antiphthisic.

Application.

Tuberculosis (pulmonary and extrapulmonary, when poor tolerance or resistance to treatment with anti-TB drugs I series): infiltrative, ulcerative and exudative processes.

Contraindications.

Hypersensitivity, acute gastritis, gastric ulcer and duodenal ulcer, yazvennыy colitis, cirrhosis and other liver diseases in the acute phase, Saint Martin's evil, renal failure, childhood (not recommended for children under 14 years).

Restrictions apply.

Diabetes, hepatic failure.

Pregnancy and breast-feeding.

When pregnancy is contraindicated; protionamid passes through the placenta. At the time of treatment should stop breastfeeding (data on the penetration of breast milk is not).

Side effects.

From the nervous system and sensory organs: dizziness, headache, impaired concentration, paraesthesia, hallucinations, excitation, anxiety, drowsiness or insomnia, depression, weakness.

From the digestive tract: dyspepsia (metallic taste in mouth, burp with rotten smell, nausea, vomiting), anorexia, dry mouth or hypersalivation, diarrhea, flatulence, abdominal pain, hepatotoxicity up to the development of hepatitis.

Other: tachycardia, menstrual disorders, weight loss, episodes of hypoglycemia in patients with diabetes, skin and other allergic reactions.

Cooperation.

It enhances the toxic effect of alcohol. When used in conjunction with other anti means shown synergy in relation to the main action. When concomitantly with isoniazid, rifampicin and pyrazinamide increases the risk of hepatotoxicity, with zikloserinom — increased cramping. During treatment, patients with diabetes should be adjusted dose of insulin or oral hypoglycemic agents. To reduce the risk of side effects, Combination with vitamin B₆ at a dose of 150-300 mg / day.

Dosing and Administration.

Inside, after meal. Adults: by 250 mg 3 once a day; with good endurance-on 500 mg 2 once a day. Patients older 60 age and body weight of less than 50 kg daily dose should not exceed 750 mg (by 250 mg 2 once a day). Babies: at the rate of 10-20 mg/kg/day. Course duration is 8-9 months.

Precautions.

The course is recommended to begin after determining germ sensitivity and prescribe the dose based on the individual sensitivity and tolerance.

Before treatment is necessary to study the gastrointestinal tract and liver function. During treatment should monitor the level of monthly activity of hepatic transaminases, gamma glutamattransferazy and alkaline phosphatase, patients with diabetes — regularly to determine the level of glycemia.

At the time of treatment should refrain from drinking alcohol. Be wary of the drivers of vehicles and people, activities which require high concentration of attention.