Protamine sulfate

When ATH:
V03AB14

Characteristic.

White fine or off-white, amorphous or crystalline powder, sparingly soluble in water.

Pharmacological action.
Hemostatic.

Application.

Bleeding, caused by an overdose of heparin, before the operation on the background heparin therapy, after operations on the heart and blood vessels with extracorporeal circulation.

Contraindications.

Hypersensitivity, idiopathic and congenital gipergeparinemii, severe hypotension, thrombocytopenia, adrenocortical insufficiency.

Side effects.

Bradycardia, Hypertension / hypotension, feeling the heat, excitation, allergic reactions.

Cooperation.

Incompatible with cephalosporins and penicillins.

Overdose.

It may be accompanied by bleeding, tk. protamine has its own anticoagulant activity.

Dosing and Administration.

B /, bolus or infusion. By 5 ml, if necessary - again via 15 m, the maximum dose - up 150 mg / h (1 mg protamine neutralizes 1 mg gyeparina). When bleeding - drip 2 receiving intervals 6 no, daily dose - 5-8 mg / kg body weight, The maximum rate - 3 day.

Precautions.

During treatment requires monitoring of blood coagulation parameters. Prior to administration, ensure the adequacy of the patient's blood volume (hypovolemia increases the risk of collapse).