PROSTUDOKS

Active material: Vitamin C, Paracetamol, Phenylephrine
When ATH: N02BE51
CCF: The drug for the symptomatic treatment of acute respiratory diseases
ICD-10 codes (testimony): J06.9, J10, R50
At KFU: 03.02.01.03
Manufacturer: Synthesis of (Russia)

Pharmaceutical form, composition and packaging

◊ Powder for oral solution from white to almost white in color with aromas of black currant.

Excipients: sodium citrate pentagemigidrat (sodium citrate 5.5-aqueous), lemon acid, sodium saccharin, black currant flavor (powdered food flavoring “black currant”), sugar.

5 g – disposable bags (5) – packs cardboard.
5 g – disposable bags (10) – packs cardboard.

Pharmacological action

Combined drug for symptomatic treatment of acute respiratory infections. Provides effective relief of symptoms of colds and flu.

The drug due to its constituent components.

Paracetamol – has antipyretic and analgesic action, reduces elevated body temperature and reduces pain syndrome (sore throat, Headache).

Phenylephrine – sympathomimetic, narrow vessels nasal, eliminates swelling of the mucous membrane of the nasal cavity and nasopharynx, resulting in reduced cough and facilitates nasal breathing.

Vitamin C (vitamin C) – fills the increased need for vitamin c for colds and flu, especially in the early stages of the disease.

Valid – 20-30 minutes after administration, duration – 4-4.5 no.

Pharmacokinetics

Data on the pharmacokinetics are not provided.

Testimony

— the symptoms of cold and flu (incl. elevated temperature, headache, chills, a feeling of nasal congestion, pain in throat when swallowing).

Dosage regimen

Adults and children over the age of 14 years should take on 1 paketiku every 4-6 no, but not more than 4 paketikov for 24 no.

The drug is not recommended to take more 5 days without consulting a doctor. If symptoms persist, should see a doctor.

Contents 1 bags poured into a glass and fill it with hot water, stir until dissolved and add sugar or honey to taste.

Side effect

Allergic reactions: sometimes – skin rash, itch, hives, angioedema.

From the hematopoietic system: rarely – thrombocytopenia, leukopenia, agranulocytosis.

From the digestive system: rarely – nausea, vomiting, epigastric pain.

Other: rarely – increased intraocular pressure, urinary retention.

Prolonged use in excess of the recommended dose can be observed hepatotoxicity and nephrotoxicity.

Phenylephrine HCL can cause nausea, Headache, increased blood pressure; rarely – palpitations. These symptoms disappear after the drug.

Contraindications

- Diseases of the cardiovascular system (incl. vыrazhennыy aortalnыy stenosis, acute myocardial infarction, integuments);

- Arterial hypertension;

- Diabetes;

- Prostatic hyperplasia;

- Zakrыtougolynaya glaucoma;

- Thyrotoxicosis;

- Pheochromocytoma;

- Pregnancy;

- Lactation;

- Children's age (to 14 years);

- Concomitant use of tricyclic antidepressants, beta-blockers, MAO inhibitors (incl. during 14 days after their cancellation);

-simultaneous reception with other paracetamolsoderžaŝimi drugs;

- Hypersensitivity to the drug.

It is a caution apply the drug in case of renal/liver failure, congenital hyperbilirubinemia (incl. Gilbert's syndrome, Dubin-Johnson and Rotor); COPD, definition, glucose-6-fosfatdegidrogenazы; blood diseases, in elderly patients.

Pregnancy and lactation

The drug is contraindicated in Prostudoks^® Pregnancy and lactation.

Cautions

Should not simultaneously apply other medicines, containing paracetamol, as well as other nonnarcotic analgetics, NSAIDs (incl. metamizol, acetylsalicylic acid, Ibuprofen), barbiturates, antiepileptic drugs, rifampicin, chloramphenicol.

The simultaneous use of other medicines should be agreed with the doctor.

The drug may distort the results of laboratory tests, evaluating concentration of glucose and uric acid in the plasma.

Effects on ability to drive vehicles and management mechanisms

When applying Prostudoksa^® Active components of the drug does not cause drowsiness and do not violate the concentration.

Overdose

An overdose of acetaminophen is evident after taking 10-15 g (15-20 bags Prostudoksa^®).

Symptoms: epigastric discomfort, nausea, vomiting, pale skin, decreased appetite, nausea, vomiting, gepatonekroz (pronounced necrosis depends directly on the extent of overdose), increase in liver transaminases, increased prothrombin time (through 12-48 h after administration), a full-blown liver disease manifests itself through 1-6 days. Rarely liver is developing at lightning speed and may be complicated by renal insufficiency (renal tubular necrosis).

Treatment: symptomatic, gastric lavage, introduction of donators SH-groups and precursors of glutathione synthesis – through methionine 8-9 hours after the overdose and N-acetylcysteine ​​after 12 no. The need for additional therapeutic interventions (further introduction of methionine, a / introduction of N-acetylcysteine) It is determined depending on the concentration of acetaminophen in the blood, and the time, elapsed since his admission.

Drug Interactions

Amphetamine mikrosomalnogo oxidation in the liver (incl. phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, that makes it possible to develop severe intoxications with small overdoses.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic drug.

Paracetamol intensifies effects of MAO inhibitors, sedative drugs, ethanol.

If you are applying to Prostudoksa^® with ethanol may develop acute pancreatitis.

If you are applying to Prostudoksa^® with antidepressants, protivoparkinsoničeskimi, antipsychotic drugs, fenotiazina derivatives increases the risk of urinary retention, dry mouth, constipation.

If you are applying to Prostudoksa^® with MCS increases the risk of glaucoma.

Together with the application Prostudoksom^® gipotenzivny guanetidina effect decreases.

If you are applying to Prostudoksa^® with guanetidine α amplifies-adrenostimuliruûŝij effect, tricyclic antidepressants – simpatomimeticeski effect of phenylephrine.

The combined application with Prostudoksom^® reduces the effectiveness of urikozuričeskih medicines.

When slowing down gastric emptying (under the influence of propantelina) you might have a delayed onset of drug action. When accelerating stomach emptying (After taking metoclopramide) the drug starts to act faster.

Prostudoks^® It may exacerbate the effects of indirect anticoagulants.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children, dry, dark place at a temperature no higher than 25 ° C. Shelf life – 2 year.