Propylthiouracil

When ATH:
H03BA02

Characteristic.

The white crystalline substance, It has a bitter taste, very slightly soluble in water.

Pharmacological action.
Antitireoidnoe.

Application.

Thyrotoxicosis (toxic goiter, toxic thyroid adenoma), preparation for the resection of the thyroid gland or treatment with radioactive iodine.

Contraindications.

Hypersensitivity, leukopenia, agranulocytosis, gipotireoz, severe liver, active hepatitis, cirrhosis of the liver.

Restrictions apply.

Pregnancy, lactation.

Pregnancy and breast-feeding.

Possible only under strict medical supervision.

Side effects.

Редко — агранулоцитоз, stomach ache, arthralgia, paraesthesia, enlargement of the thyroid gland, allergic reactions (skin rash, hives); rarely (when using high doses of) — поражения печени, incl. transient cholestasis, thrombocytopenia, lymphadenopathy; в отдельных случаях — нервно-мышечные расстройства, polyarthritis, the taste and smell, vasculitis, lupus-like syndrome, periarteritis nodosa, nausea, vomiting, dizziness, violation of erythropoiesis, gemoliz, Positive Coombs' test, interstitial pneumonia, peripheral edema, alopecia.

Cooperation.

Thyreostatic effect of weakening the iodine-containing medications, incl. X-ray contrast agents. When concomitantly with propranolol, or coumarin derivatives requires correction of doses.

Overdose.

Symptoms: nausea, vomiting, headache, fever, arthralgia, itch, edema, pancytopenia, agranulocytosis, dermatitis, hepatitis, neuropathy, excitation / depression.

Treatment: simptomaticheskaya therapy, maintaining vital functions; In some cases gastric lavage and appointment of activated carbon (It should take into account rapid absorption of the substance).

Dosing and Administration.

Inside, without chewing, drinking plenty of fluids. Adults and children over 10 лет — по 75–100 мг/сут, в тяжелых случаях и после предшествующей нагрузки йодом — до 300–600 мг/сут в несколько приемов; поддерживающая доза — 25–150 мг/сут. Для детей 6–10 лет начальная доза — 50–150 мг/сут, supporting is 25-50 mg/day. Новорожденным — по 5–10 мг/кг/сут в 3 admission (in the absence of effective dose increase 1.5-2 times); поддерживающая доза — 3–4 мг/кг/сут. Интервал между приемами — 6–8 ч. The duration of treatment is determined individually.

Precautions.

During treatment requires regular monitoring of blood cell composition and functional state of the thyroid gland (determining the level of thyroid hormones and / or blood thyrotropin). When pathological changes of blood cells and increase the activity of transaminases should consult a doctor. Since agranulocytosis may develop within a few hours, the patient must be informed of his symptoms (fever, malaise, tonsillar angina, stomatitis) and the need for immediate treatment to the doctor, and the study of the blood picture. The development of goiter and hypothyroidism (Chronic overdose) require discontinuation of treatment.

When used during pregnancy and breast-feeding dose should be as low as possible in order to prevent miscarriage, as well as the development of hypothyroidism and goiter in the fetus or newborn.

Cooperation