POLINADIM

Active material: Difengidramin, Nafazolin
When ATH: S01GA51
CCF: The drug with anti-allergic and vasoconstrictor activity for topical use in ophthalmology
ICD-10 codes (testimony): H10.1, H10.2, H10.4
When CSF: 13.01.03.02
Manufacturer: Synthesis of (Russia)

Pharmaceutical form, composition and packaging

◊ Eye drops in the form of a transparent, low color liquid.

Excipients: boric acid (15 mg / ml), metiltsellyuloza vodorastvorimaya (1.5 mg / ml), sodium tetraborate decahydrate (500 ug / ml), disodium эdetat (600 ug / ml), water d / and (to 1 ml).

10 ml – dropper bottle plastic (1) – packs cardboard.

Pharmacological action

Combination preparation for topical application in ophthalmology.

Difengidramin – gistaminovыh blocker H₁-receptors, It has anti-allergic effect. It reduces swelling, itch, lacrimation.

Nafazolin – alpha-agonists, causes prolonged peripheral vasoconstriction. Due to the action of the vasoconstrictor with the local application has anti-edema effect.

Pharmacokinetics

Data on the pharmacokinetics of the drug Polinadim^® not provided.

Testimony

- Acute allergic conjunctivitis (incl. pollinozny conjunctivitis);

- conjunctivitis with drug allergy;

- Infectious diseases of the eye with a sharp allergic component (as an additional means).

Dosage regimen

Adults at acute symptoms the drug is prescribed for 1 dropwise into the conjunctival sac every 3 h to reduce swelling and irritation of the eyes, then – by 1 drop 2-3 times / day until the disappearance of clinical symptoms.

Children over 2 years appointed 1-2 drops / day.

Duration of treatment – no more 5 days. The need for longer use of the drug doctor decides individually.

If symptoms persist, conjunctival irritation more 72 h discontinue using the product.

Side effect

Local reactions: symptoms of irritation of the conjunctiva (in the eye burning, conjunctival hyperemia, itch), as well as blurred vision, increased intraocular pressure, midriaz, sore eyes, xeromycteria. These reactions disappear after drug withdrawal. Described an isolated case of corneal clouding (when used for 7 days at least 10 time / day), which disappeared after discontinuation of drug treatment.

Systemic reactions: rarely (especially in children and elderly patients) – pale skin, tachycardia, precordialgia, increased blood pressure, increased sweating, tremor, headache, excitation, nausea, drowsiness, dizziness.

Contraindications

- conjunctival xerosis (keratoconjunctivitis sicca, Sjogren syndrome);

- simultaneous application with MAO inhibitors and the period during 10 days after their cancellation;

- Zakrыtougolynaya glaucoma;

- Pregnancy;

- Lactation;

- Children up to age 2 years;

- Hypersensitivity to the drug.

FROM caution use in patients with hyperthyroidism, hypertension, atherosclerosis, Arrhythmia, chronic rhinitis, asthma, adrenal adenoma, in elderly patients, in benign prostatic hyperplasia with residual urine.

Pregnancy and lactation

Use of the drug during pregnancy and lactation (breast-feeding) possibly only, when the expected benefit to the mother outweighs the potential risk to the fetus or child.

Cautions

Do not use the medication more frequently, than every 3 no (during 5 days).

The preparation is not intended for oral administration, or as injections.

In the case of the onset of symptoms, evidence of systemic absorption, you must stop using the product.

When symptoms of allergies and is not recommended to use soft contact lenses during treatment with. If their use is necessary, the lenses should be removed before instillation and set back, no earlier than 15 m.

Effects on ability to drive vehicles and management mechanisms

Because after instillation temporarily disrupted the clarity of, immediately after application of the drug to patients should refrain from driving motor vehicles and activities, requiring visual acuity.

Overdose

The local application of a drug overdose is unlikely.

Symptoms: children under the age of 6 years with prolonged and frequent use of possible CNS depression, gipotermiя, long mydriasis, increased blood pressure, tachycardia.

Treatment: symptomatic therapy.

Drug Interactions

With simultaneous use of tricyclic antidepressants may increase the vasoconstrictor action nafazolina.

The use of MAO inhibitors simultaneously with or within naphazoline 10 days after their withdrawal can lead to a hypertensive crisis.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children, dark place at a temperature of 15 ° to 25 ° C; Do not freeze. Shelf life – 2 year.

After opening the bottle shelf life of the drug – 1 Months.