Fenilpiratsetam
When ATH:
N06BX
Pharmacological action
Nootropics. According to the information of the manufacturer has expressed antiamnesticescoe effect, activates the integrative activity of the brain, It contributes to memory consolidation, It improves concentration and mental performance, It facilitates the learning process, It speeds up the transfer of information between the hemispheres of the brain, increases the resistance of brain tissue hypoxia and toxic effects, It has an anticonvulsant effect and anxiolytic activity, regulates the activation and inhibition of the central nervous system, improves mood.
Fenilpiracetam has a positive effect on metabolism and blood circulation of the brain, stimulating redox processes, It increases energy potential due to the utilization of glucose, improving regional blood flow in the ischemic areas of the brain. Increases of noradrenaline, dopamine and serotonin in the brain. Does not affect the level of GABA, It binds to GABA- and GAMKB-receptors, does not have a significant effect on spontaneous bioelectrical brain activity.
Fenilpiracetam has no effect on respiratory and cardiovascular systems. It has a weakly expressed diuretic effect. It has anoreksigennoy activity in exchange application.
Fenilpiracetam provides moderately stimulatory effect on motor reactions, increases physical performance. Mild psihostimuliruty effect of the drug is combined with anxyolytic activity. Fenilpiracetam improves mood, It has analgesic effect, increasing the pain threshold, It has adaptogenic effect, increasing the body's resistance to stress in the face of increased mental and physical exertion, when fatigue, hypokinesia and immobilization, at low temperatures.
Against the backdrop of marked improvement in fenilpiracetama view (increase in severity, brightness and visual fields). Fenilpiracetam improves blood circulation in the lower limbs. Fenilpiracetam stimulates the production of antibodies in response to the introduction of Antigen, that indicates its immunostimulirujushie properties, but at the same time it does not cause the development of immediate hypersensitivity reactions or modify the allergic inflammatory reaction of the skin, caused by the introduction of a foreign protein. In kursovom application fenilpiracetama is not developing drug dependence and tolerance. When you remove the drug development not observed withdrawal.
Fenilpiracetama effect manifests itself after one use, What is important in the use of the drug in extreme conditions. Significantly enhances the action of nootroponah drugs.
Pharmacokinetics
Absorption and distribution
After receiving intake of rapidly absorbed from the digestive tract, distributed in various organs and tissues, easily penetrates the blood-brain barrier. The absolute bioavailability of the drug when taken orally makes 100 %. The maximum concentration in the blood is achieved through 1 no.
Metabolism and excretion
Fenilpiratsetam is not metabolized in the body and is excreted unchanged in. About 40 % excreted in the urine, 60 % is the jelchew and then. The half-life of 3-5 no.
Dosage regimen
The mode set individually.
The average single dose is 150 mg (100-250 mg), the average daily intake is 250 mg (200-300 mg). The maximum daily dose - 750 mg. The multiplicity of reception is 1-2 once a day. The daily dose to 100 mg can be taken 1 once a day (morning), more 100 mg is recommended to divide the 2 reception. Duration of treatment, ranging from 2 weeks before 3 months. The average course of treatment — 30 days. If necessary, designate a second course of treatment a month.
To increase the work capacity of the prescribed 100-200 mg 1 every day in the morning during 2 weeks (for athletes — for 3 days).
When alimentary-constitutional obesity is 100-200 mg 1 every day in the morning during 30-60 days.
Fenilpiracetam is inside after eating. It is not recommended to take fenilpiracetam after 15:00.
Testimony
CNS disease different Genesis (especially diseases of vascular origin or associated with disorders of metabolic processes in the brain and intoxication, eg, post-traumatic states and phenomena of chronic cerebrovascular insufficiency), accompanied by a deterioration in intellectual-mental functions, reduction in motor activity.
Neurotic state, manifested apathy, increased exhaustion, reduction of psychomotor activity, violation of attention, memory impairment.
Violations of learning processes.
Depression, mild.
Psihoorganiceskie syndromes, manifesting intellectual mnesticheskimi disorders and symptoms apatiko-abulicheskimi, as well as apathetic State of schizophrenia.
Apnoea.
Obesity (alimentary-constitutional genesis).
Prevention of hypoxia, increase resistance to stress, correction of functional status in extreme environments professional activities with a view to preventing the development of fatigue and increase mental and physical performance, correction of circadian Biorhythm, inversion of the sleep-wake cycle».
Alcoholism (to reduce symptoms of asthenia, depression, intellectual-mental disorders).
There are also cases of effective use of the drug when the neuritis of the auditory nerve, What is the subject of the attention of researchers
Side effects
CNS: while taking the drug after 15:00 possible insomnia. Some patients in the first 3 day admission escalates agitation, flushing of the skin, feeling the heat.[3] When higher dosage of the drug may severe mood swings. There is also an increased irritability
Impact on the ability to drive vehicles and management mechanisms
It should be taken into account, that the excessive psycho-emotional exhaustion on the background of chronic stress and fatigue, chronic insomnia, single dose on the first day of Fenilpiracetama may cause a sharp need for sleep. Therefore, patients, activities that require increased attention and psychomotor speed reactions, we recommend that you begin supplementation in non-working days.
Contraindications
Hypersensitivity to the drug.
Drug Interactions
It may exacerbate the effects of Fenilpiracetam drugs, stimulating the central nervous system, antidepressants and nootropics. Fenilpiracetam shows the antagonism katalepticheskomu effects of Neuroleptics, as well as the manifestation of the action of soporific weakens ethanol and hexanal.
Pregnancy and lactation
Fenilpiracetam should not be appointed during pregnancy and lactation because of lack of clinical trial data.
Fenilpiracetam does not have teratogenic, mutagenic and embryotoxic action.
Use in Pediatrics
Not recommended to appoint Fenilpiracetam children, due to the lack of clinical data on the use of drugs in paediatric practice.
Cautions
The caution should appoint drug patients with severe Fenilpiracetam organic lesions of the liver and kidney, heavy course of arterial hypertension, atherosclerosis; sick, have suffered panic attacks, acute psychotic state, accompanied by psychomotor agitation (because it may exacerbate anxiety, panic, hallucinations and delusions); sick, prone to allergic reactions to the group nootropics pyrrolidone.
Fenilpiracetam is not carcinogenic actions. Released on the doctor's prescription.
Overdose
Manufacturer, the cases of drug overdose does not report. According to other sources: possible hallucinations, delirium, insomnia, allergic reactions. If necessary spend symptomatic therapy.
When one-time admission to more 500 mg can cause a State of panic, rasterjanost. It is not recommended to use immediately before exercise.
The lethal dose is 800 mg 1 kg weight.
