Phenindione

When ATH:
B01AA02

Characteristic.

White or creamy-white crystals. Almost odorless. Very little soluble in water and alcohol. Solutions are coloring from orange to orange-red.

Pharmacological action.
Antykoahulyantnoe.

Application.

Prevention and treatment of thrombosis (particularly the deep veins of the lower extremities) and thrombophlebitis, thromboembolic complications (pulmonary embolism, embolic stroke and others.) and thrombus formation in the postoperative period; mechanical heart valve prostheses (constant reception), geparinoterapiя (the combined use of).

Contraindications.

Hypersensitivity, hemorrhagic syndrome, baseline prothrombin less 70%, pregnancy (I trimester).

Restrictions apply.

Increased vascular permeability, the liver and kidneys, malignant neoplasms, erosive and ulcerative lesions of the gastrointestinal tract, pericarditis, the first days after birth.

Side effects.

Hemorrhagic Syndrome (gastrointestinal, Uterine, nosebleeds, hematuria, bleeding into the muscles and other organs and parenchymal.), inhibition of hematopoiesis, dyspeptic disorders (diarrhea, nausea), toxic hepatitis, allergic reactions (hyperthermia, dermatitis).

Cooperation.

Enhances the effect of other. antykoahulyantы, thrombolytic agents and antiaggregant, azathioprine, allopurinol, Amiodarone, Anabolic, narcotic analgesics, androgens, antibiotics, tricyclic antidepressants, oxidizing agents urine, glucocorticoids, diazoksid, disopyramide, Isoniazid, nalidixic acid, clofibrate, metronidazol, paracetamol, reserpine, crystalloid solutions, ʙutadion, sulfonamides, tocopherol, disulьfiram, quinidine, cyclophosphamide, cimetidine, thyroid hormones, ослабляют — ощелачивающие мочу средства, propranolol, antacids, fenazon, barbiturates, vitamins K and C, haloperidol, Diuretic, Carbamazepine, oral contraceptives, meprobamate, rifampicin, cholestyramine.

Overdose.

Symptoms: hemorrhagic syndrome (gastrointestinal, Uterine, nosebleeds, hematuria, bleeding into the skin, muscle, parenchymal organs, and others.).

Treatment: vitamin K PO / in; in the development of serious bleeding vitamin K used in / slow (1 mg / min) в общей дозе — 10–50 мг (normalizes elevated prothrombin time during the 6 no). When massive bleeding or in patients with hepatic insufficiency simultaneously applied fresh frozen plasma. Perhaps the use of aminocaproic acid, vitamins C and P.

Dosing and Administration.

Inside. IN 1 день — в суточной дозе 0,12–0,18 г в 3–4 приема, in 2 день — 0,09–0,15 г/сут, затем — по 0,03–0,06 г/сут в 1–2 приема, depending on the content in the blood prothrombin. Prothrombin index value is maintained at 40-60%.

Precautions.

In addition the study MF, requires strict medical supervision and regular examination of blood coagulation extended (coagulogram, tromboelastogramma, platelet count).

Cautions.

Терапия может сопровождаться окрашиванием ладоней в оранжевый и мочи — в розовый цвет.