Primary biliary cirrhosis – treatment of disease. Symptoms and prevention of the disease primary biliary cirrhosis

Primary biliary cirrhosis – What is this disease? Primary biliary cirrhosis-autoimmune liver disease, prone to slow progression. The disease is characterized by lesions of biliary tract and diffuse liver lesion, in which liver tissue death and its replacement at the junction (fibrous) cloth.

Of fibrous tissue are formed by large and small sites, modifying the structure of the liver.

Usually, primary biliary cirrhosis occurs in middle-aged people, develops mainly in women 40-60 years.

Primary biliary cirrhosis – The cause of the

The cause of primary biliary cirrhosis is not fully understood. It is believed, a role in the development of this pathology plays a heredity. When this disease happens defeat liver cells own cells of the immune system. Development of primary biliary cirrhosis may be associated with such abnormalities as celikaija and rheumatoid arthritis.

Primary biliary cirrhosis – Symptoms

For a long time, the disease may manifest itself in no way. In most cases primary biliary cirrhosis diagnosed in later stages.

Common symptoms of primary biliary cirrhosis are:

  • · астенический синдром;
  • · skin itching;
  • Decrease in body weight;
  • · снижение артериального давления;
  • · гипер-гамма-глобулинемия.

To liver disease signs should include:

  • · синдром малых печеночных признаков (Telangiectasia, эritema, total feminization appearance, hypertrophy of salivary glands, tendency to bruise, icteric color skin, lejkonihii, symptom "drumsticks" and "watch glasses" and other symptoms);
  • · синдром портальной гипертензии (splenomegaly, ascites, esophageal varices, expansion of the upper prjamokishechnyh of veins).

Primary biliary cirrhosis – Diagnostics

Diagnosis of primary biliary cirrhosis includes:

  • · сбор анамнеза заболевания и анамнеза жизни больного;
  • · анализ жалоб больного;
  • · анализ семейного анамнеза. The doctor investigates, ill anyone from relatives of patient pathology;
  • · осмотр больного;
  • · оценка психического состояния пациента;
  • · лабораторные методы исследования (general blood analysis, biochemical blood analysis, coagulogram, definition of antimitohondrial'nyh antibodies, general urine analysis, a blood test for hepatitis, coprogram, analysis of feces for the presence of worms, other studies);
  • · инструментальные методы исследования (ultrasound examination of abdominal cavity organs, esophagogastroduodenoscopy, CT scan, roasted biopsy, elastography, other research methods);

Primary biliary cirrhosis – Types of disease

This disease occurs in four stages. At the first (Elementary) stage may include primary symptoms, associated with the development of inflammation in the liver. In the second stage expands Portal tracts, bile duct proliferation occurs. At the third stage develops septal'nyj fibrosis, Portal routes are replaced with scar tissue. At the fourth stage develops cirrhosis.

Primary biliary cirrhosis – Actions of the patient

Treatment of this disease is carried out by gastrojenterologom.

Primary biliary cirrhosis – Treatment

Treatment for primary biliary cirrhosis includes the following activities:

  • · применение желчегонных препаратов для уменьшения застойных явлений в желчных протоках (ursosan, etc);
  • · назначение специальной диеты, which provides for the reduction of the proportion of protein foods diet, as well as increasing plant foods;
  • · проведение иммунодепрессивной терапии в случае обнаружения повышенной реакции иммунной системы по отношению к собственным клеткам печени;
  • · проведение противовоспалительной и антибактериальной терапии;
  • · прием цитостатических препаратов для снижения интенсивности образования рубцовой ткани в печени;
  • · назначение гепатопротекторов для улучшения деятельности печени;
  • · прием антиоксидантов и витаминно-минеральных комплексов;
  • · ограничение психических и физических нагрузок.

Primary biliary cirrhosis – Complications

Primary biliary cirrhosis may develop the following complications:

  • · асцит;
  • · варикозное расширение вен пищевода;
  • · спутанность сознания;
  • · гепатоцеллюлярная карцинома;
  • · печеночно-легочный синдром;
  • · печеночная колопатия;
  • · печеночная гастропатия;
  • · бесплодие.

Primary biliary cirrhosis – Prevention

The main preventive measures in respect of primary biliary cirrhosis are:

  • · регулярное посещение врача и соблюдение всех его рекомендаций с целью предупреждения прогрессирования заболевания;
  • · ограничение физических и психоэмоциональный нагрузок;
  • · rejection of bad habits;
  • · прием витаминно-минеральных комплексов;
  • · умеренные физические нагрузки;
  • · своевременное лечение вирусных гепатитов;
  • · своевременное лечение заболеваний желудочно-кишечного тракта.

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