Primary biliary cirrhosis – treatment of disease. Symptoms and prevention of the disease primary biliary cirrhosis

Primary biliary cirrhosis – What is this disease? Primary biliary cirrhosis-autoimmune liver disease, prone to slow progression. The disease is characterized by lesions of biliary tract and diffuse liver lesion, in which liver tissue death and its replacement at the junction (fibrous) cloth.

Of fibrous tissue are formed by large and small sites, modifying the structure of the liver.

Usually, primary biliary cirrhosis occurs in middle-aged people, develops mainly in women 40-60 years.

Primary biliary cirrhosis – The cause of the

The cause of primary biliary cirrhosis is not fully understood. It is believed, a role in the development of this pathology plays a heredity. When this disease happens defeat liver cells own cells of the immune system. Development of primary biliary cirrhosis may be associated with such abnormalities as celikaija and rheumatoid arthritis.

Primary biliary cirrhosis – Symptoms

For a long time, the disease may manifest itself in no way. In most cases primary biliary cirrhosis diagnosed in later stages.

Common symptoms of primary biliary cirrhosis are:

• · Asthenic syndrome;
• · skin itching;
• Decrease in body weight;
• · Reducing blood pressure;
• · Hyper-gamma-globulinemia.

To liver disease signs should include:

• · Small hepatic signs syndrome (Telangiectasia, эritema, total feminization appearance, hypertrophy of salivary glands, tendency to bruise, icteric color skin, lejkonihii, symptom "drumsticks" and "watch glasses" and other symptoms);
• · Portal hypertension syndrome (splenomegaly, ascites, esophageal varices, expansion of the upper prjamokishechnyh of veins).

Primary biliary cirrhosis – Diagnostics

Diagnosis of primary biliary cirrhosis includes:

• · Collection of anamnesis of the disease and anamnesis of the patient's life;
• · Analysis of patient complaints;
• Family history analysis. The doctor investigates, ill anyone from relatives of patient pathology;
• · Inspection of the patient;
• · Assessment of the mental state of the patient;
• Laboratory research methods (general blood analysis, biochemical blood analysis, coagulogram, definition of antimitohondrial'nyh antibodies, general urine analysis, a blood test for hepatitis, coprogram, analysis of feces for the presence of worms, other studies);
• · Instrumental research methods (ultrasound examination of abdominal cavity organs, esophagogastroduodenoscopy, CT scan, roasted biopsy, elastography, other research methods);

Primary biliary cirrhosis – Types of disease

This disease occurs in four stages. At the first (Elementary) stage may include primary symptoms, associated with the development of inflammation in the liver. In the second stage expands Portal tracts, bile duct proliferation occurs. At the third stage develops septal'nyj fibrosis, Portal routes are replaced with scar tissue. At the fourth stage develops cirrhosis.

Primary biliary cirrhosis – Actions of the patient

Treatment of this disease is carried out by gastrojenterologom.

Primary biliary cirrhosis – Treatment

Treatment for primary biliary cirrhosis includes the following activities:

• The use of choleretic drugs to reduce congestion in the bile ducts (ursosan, etc);
• · Purpose of a special diet, which provides for the reduction of the proportion of protein foods diet, as well as increasing plant foods;
• · Conducting immunosuppressive therapy in the event of an increased reaction of the immune system in relation to the own liver cells;
• · Conducting anti -inflammatory and antibacterial therapy;
• · Taking cytostatic drugs to reduce the intensity of the formation of scar tissue in the liver;
• The purpose of hepatoprotectors to improve liver activity;
• · Reception of antioxidants and vitamin-mineral complexes;
• · Limiting mental and physical exertion.

Primary biliary cirrhosis – Complications

Primary biliary cirrhosis may develop the following complications:

• · Ascites;
• Varicose extension of the veins of the esophagus;
• · Confusion of consciousness;
• · Hepatocellular carcinoma;
• · Peni-leg syndrome;
• · Hepatic kolopathy;
• · Hepatic gastropathy;
• · Infertility.

Primary biliary cirrhosis – Prevention

The main preventive measures in respect of primary biliary cirrhosis are:

• · Regular visit to the doctor and compliance with all his recommendations in order to prevent the progression of the disease;
• · Limiting physical and psychoemotional loads;
• · rejection of bad habits;
• · Reception of vitamin-mineral complexes;
• Moderate physical activity;
• Timely treatment of viral hepatitis;
• Timely treatment of diseases of the gastrointestinal tract.