PANADOL (Pills, Film-coated)
Active material: Paracetamol
When ATH: N02BE01
CCF: Analgesic-antipyretic
When CSF: 03.02.01.01
Manufacturer: GlaxoSmithKline Consumer Healthcare (Great Britain)
DOSAGE FORM, COMPOSITION AND PACKING
◊ Pills, Film-coated white, kapsulovidnoj shape with a flat edge, Embossed “PANADOL” на одной стороне и риской — на другой.
| 1 tab. | |
| paracetamol | 500 mg |
Excipients: corn starch, pre-gelatinized starch, potassium sorbate, povidone, talc, stearic acid, triacetine, gipromelloza.
6 PC. – blisters (1) – packs cardboard.
6 PC. – blisters (2) – packs cardboard.
12 PC. – blisters (1) – packs cardboard.
12 PC. – blisters (2) – packs cardboard.
DESCRIPTION OF ACTIVE SUBSTANCES
Pharmacological action
Analgesic, pyretic.
Application
The pain of mild to moderate intensity (headache and toothache, migraine, backache, arthralgia, myalgia, neuralgia, menalgïya), feverish syndrome with colds.
Contraindications
Hypersensitivity, violation of kidney and liver function, alcoholism, childhood (to 6 years).
Side effects
Agranulocytosis, thrombocytopenia, anemia, počečnaâ how, aseptic pyuria, interstitsialynыy glomerulonephritis, allergic reactions such as skin rash.
Cooperation
Increases effect of anticoagulants (coumarin derivatives) and the likelihood of liver damage hepatotoxic drugs. Metoclopramide increases, and cholestyramine reduces the absorption rate. Barbiturates reduce the antipyretic activity.
Overdose
Symptoms: first 24 h-pallor, nausea, vomiting and abdominal pain; through 12-48 hours — damage to the kidneys and liver, with the development of liver failure (encephalopathy, coma, death), cardiac arrhythmias and pancreatitis. Possible liver damage when taken 10 g and more (adult).
Treatment: the appointment of methionine inside or / in the introduction of N-acetylcysteine.
Dosing and Administration
Inside and rectally, adults and children over 12 years of 0.5-1 g to 4 once a day; The maximum daily dose - 4 g, the course of treatment is 5-7 days. Children 6-12 years-240-480 mg, 1-6 years — 120-240 mg, from 3 Months before 1 the year is 24-120 mg to 4 once a day for 3 days. Soluble tablets before taking dissolved in 1/2 cup water.
Precautions
The risk of overdose is increased in patients with alcoholic liver disease netsirroticheskogo nature.
Cooperation
| Active substance | Description of interaction |
| Glibenclamide | FMR: synergism. Against the background of the effect of paracetamol is enhanced. |
| Metoclopramide | FKV. It accelerates absorption. |
| Ethanol | Against the background of paracetamol should not be taken Alcoholic drinks. |
