Panadol EXTRA (Pills, coated)

Active material: Caffeine, Paracetamol
When ATH: N02BE71
CCF: Analgesic-antipyretic
ICD-10 codes (testimony): G43, J06.9, J10, K08.8, M25.5, M79.1, M79.2, N94.4, N94.5, R50, R51, R52.0, R52.2
When CSF: 03.02.01.03
Manufacturer: GlaxoSmithKline Consumer Healthcare (Great Britain)

Pharmaceutical form, composition and packaging

Pills, coated white, kapsulovidnoj shape with a flat edge, Embossed “PANADOL EXTRA” on one side.

Excipients: pre-gelatinized starch, corn starch, povidone, potassium sorbate, talc, stearic acid, Croscarmellose sodium, gipromelloza, triacetine.

6 PC. – blisters (1) – cardboard boxes.
6 PC. – blisters (2) – cardboard boxes.
12 PC. – blisters (1) – cardboard boxes.
12 PC. – blisters (2) – cardboard boxes.

DESCRIPTION OF ACTIVE SUBSTANCES.

Pharmacological action

Combined preparation, which is determined by the components, its composition.

Caffeine has psihostimulirutee (stimulates psychomotor brain centers), analepticescoe action, increases the effect of analgesics, eliminates drowsiness and fatigue, enhances physical and mental fitness.

Paracetamol – antipyretic and analgesic action (through inhibition of COX and oppression of prostaglandin synthesis affects the Centre of thermoregulation in the hypothalamus and carrying out pain impulses in the central nervous system).

Pharmacokinetics

–

Testimony

Pain syndrome (mild to moderate severity):

- Headache;

- Migraine;

— bone pain;

- Myalgia;

- Neuralgia;

-arthralgia;

- Algomenorrhea;

- toothache.

Feverish syndrome, colds, flu.

Dosage regimen

Inside adult – by 2 tab. 4 times a day at intervals of not less than 4 no. The maximum daily dose – 8 tab.

Duration of use – no more 10 days.

Side effect

Allergic reactions (skin rash, angioedema, hives), dyspepsia (incl. nausea, epigastric pain).

In rare cases, – gemoliticheskaya anemia, thrombocytopenia.

With long-term use in high doses – gepatotoksichnostь, nephrotoxicity, pancytopenia.

Contraindications

- Hypersensitivity;

-severe liver and/or kidney failure;

- Epilepsy;

- Deficiency of glucose-6-fosfatdegidrogenazы.

C care: pregnancy, lactation, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), childhood (to 12 years).

Cautions

Excessive use of kofeinsoderžaŝih products (coffee, tea) in the face of treatment can cause symptoms of overdose.

Prolonged (more 1 Sun) the treatment is necessary to monitor patterns of peripheral blood and functional state of the liver. Without consulting a doctor take no more 3 days in the treatment of febrile syndrome and no more 5 days – When bolevom syndrome.

Can change the doping control test results of athletes.

Difficult diagnosis in simptomokomplekse “acute abdomen”.

Patients, suffering from atopic bronchial asthma, hay fever, There is an increased risk of allergic reactions.

During treatment should abandon the consumption of ethanol (increased risk of Hepatotoxicity).

Overdose

Symptoms: pale skin, decreased appetite, nausea, vomiting; gepatonekroz (the severity of necrosis due to intoxication is directly dependent on the extent of overdose), activity increase “Hepatic” transaminases, increased prothrombin time; detailed clinical picture of liver damage is manifested through 1-6 days.

Treatment: introduction of donators of SH-groups and precursors of glutathione synthesis by methionine 8-9 hours after the overdose and N-acetylcysteine – through 12 no.

To prevent late hepatotoxicity carry out gastric lavage.

Drug Interactions

Do the MAO inhibitors.

Reduces the effectiveness of drugs urikozuricheskih.

Caffeine speeds up absorption of ergotamine.

Under the influence of paracetamol time breeding chloramphenicol increases 5 time.

In the long admission paracetamol might increase the effect of anticoagulants (derived dikumarina).

Simultaneous intake of paracetamol and ethanol increases the risk of hepatotoxic effects and acute pancreatitis.

Barbiturates, phenytoin, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants and other amphetamine mikrosomalnogo oxidation increase the production of active metabolites gidroksilirovannyh, determining the possibility of developing severe intoxications with small overdoses.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxicity.

Metoclopramide and domperidone increase, and cholestyramine reduces induction.