Acute leukemia makrofahalnыy

Acute leukemia macrophage refers to a group of macrophage tumor.

This form of leukemia is most often begins vnekostnomozgovymi lesions. Acute leukemia cells of macrophage nature observed less often, than chronic, and less difficult to diagnose, as the nature of the tumor macrophage elements blast type, which is represented by acute leukemia macrophage, clear. These cells are characterized by considerable polymorphism and atypia blast nucleus and cytoplasm.

Monocyte-macrophage cells nature cytochemically set using the same reactions, which are characteristic of monoblastov and monocytes. But the nature of the macrophage blasts are often unable to judge by circumstantial evidence: they are found in clusters of atypical cells, including macrophages ugly, having a structural core. Along with accumulations of macrophage elements in bone marrow and in the enlarged spleen may be increased percentage of lymphoid cells, some of which gives a positive response to α-naftilesterazu, repressed sodium fluoride. Acute leukemia macrophage often occurs with anemia and granulocytopenia.

Unlike acute monoblastic acute leukemia are rarely characterized by macrophage gingival hyperplasia, tonsils, may occur more frequently hepatosplenomegaly. The infiltration of the liver in this form of leukemia is often complicated by jaundice. The most important and permanent feature of the disease - high fever, aseptic, sometimes with chills.