Tumors synovium

The synovium are three layers: Two-elastic fibrous kolagenovo (superficial and deep) and a coating, lining the joint cavity and bursa. The covering layer consists of synoviocytes, among which there are three kinds of cells: A, B and C.

A-cell exhibit phagocytic activity and called macrophage (phagocytic) sinoviocitami.

B-cell - Fibroblastic synoviocytes elongated, with an oval or more elongated nucleus and the cytoplasm rather wide, often stretched from one pole of the cell. They have the ability to produce hyaluronic acid, which is included in the synovial fluid.

C-cell - Intermediate forms synoviocyte, with signs and A-, and B- cell.

Malignant synovioma – Synovial sarcoma

Malignant synovioma (synovial sarcoma) - Tumor, developing from the synovium of joints, tendon sheaths and synovial bags. Make Up 8,4 % of all malignant tumors of soft tissues. It occurs with equal frequency in both sexes at any age, but mainly to 50 years. Often localized in the large joints of the upper and lower extremities.

The tumor grows in a clearly limited by the surrounding host tissue, which is associated with or part of the joint capsule tendon, or connect with him only leg. A morphological study noted a wide variety of structural elements of synovial sarcoma, which makes it difficult diagnosis.

Polymorphic tumor cell substrates, However, the dominant elements are the fibroblast-like cells, It constitutes a kind of tumor stroma, and light, epithelioid, similar to the coating layer synoviocytes.

Based on the morphological characteristics of the tumor, histologically distinguish mainly two-phase (Spindle and epithelioid types) and preferably a single phase (spindle cell or epithelioid type) synovial sarcoma.

Biphasic synovial sarcoma

Biphasic synovial sarcoma is characterized by the presence of punctate extended, fibroblast, multiple polymorphic cells with large hyperchromatic nuclei and 1- 2 nucleoli. The cytoplasm is poorly developed, pull on the pole cells. Located in a separate randomly intertwined bundles, These cells resemble a picture melkoveretenokletochnoy sarcoma.

Bright cells, like epithelioid, oval, round or more elongated shape. The core of elongate, prominent, It occupies almost the entire cage, 1-2 is the nucleolus. Cytoplasmic bright, basophilic, quite abundant, Homogeneous. Sometimes medications can meet giant cells. In the cytoplasm of cells is detected light PAS-positive substance.

Both types of cells are arranged on a background of pink and purple base material.

Single-phase synovial sarcoma

Single-phase synovial sarcoma morphology presented a large light cell type sinoviblastov, or, it occurs more often, spindle-shaped cells. Can meet giant cells.