Dangerous drug interactions, which may result in hospitalization or death
Particularly dangerous and lethal combination of drugs | ||
Drug or group of drugs | Drug or group of drugs | Cooperation (recommendations, notes) |
| a- и b- adrenomimetiki (R03CA, R03AA, R03DB, S01EA) | a- и b- adrenomimetiki (R01AA, R01AB) | Dangerous heart rhythm disorders, severe hypertension, possible death |
| MAO inhibitors (N06AF, N06AB, C02KC) | Joint application of α- и b- adrenomimetikov and MAO inhibitors is dangerous, even if adrenomimetiki applied in the form of eye drops (klonidin, guanfaцin, moxonidine improve sensitivity to kateholaminam, and MAO inhibitors lead to the accumulation of past). In their joint application possible hypertension, hyperthermia, convulsions, death (The interval between taking drugs for at least two weeks) | |
| Drugs for general anesthesia (N01A) | Combined use not recommended, as may develop life-threatening heart rhythm disorders | |
| b- adrenomimetiki (G02CA, R03AB, R03AC, R03CB, R03CC) | Glucocorticoids (H02AB) | Joint application of r-adrenomimetikov and glucocorticoids in late pregnancy may lead to the development of pulmonary edema in the mother |
| Azathioprine | Mielodepressanta * | Intensifies the toxic effect. (Dangerous combination, You must avoid) |
| NSAIDs, Butilpirazolidiny (M01AA) | Intensifies the toxic effect. (Dangerous combination, You must avoid) | |
| Salazopiridazin | Amplified toxic effect azatioprina. (Dangerous combination, You must avoid) | |
| Suxamethonium chloride | Potentiated neiromyshecnaya blockade. (Dangerous combination, You must take into account) | |
| Sulfonamides (J01EB, J01EC, J01ED) | Intensifies the toxic effect. (Dangerous combination, You must avoid) | |
| Chloramphenicol | Intensifies the toxic effect. (Dangerous combination, You must avoid) | |
| Cytostatics (L01, L01AX) | Intensifies the toxic effect. (Dangerous combination, You must avoid) | |
| Rauwolfia alkaloids (C02AA) | Alkogol′soderžaŝie drugs | Joint application may cause ortostaticeski collapse |
| Α-adrenoceptor blockers (C02CA) | Joint application may cause ortostaticeski collapse | |
| Alьfuzozin | Antihypertensive drugs (C02) | If you are applying to al′fuzozina with antigipertenzivei drugs (especially calcium channel blockers) perhaps marked reduction of blood pressure, until the development of collapse (!) |
| Amantadin | Gidroxlortiazid | Intensifies the toxic effect of midantana (traffic violation, hallucinations: delirium, vision, purchasing reality) |
| Triamterene | Intensifies the toxic effect of midantana (traffic violation, gallûcina-tion, delirium) | |
| Aminofillin | Dextrose | Aminophylline, you cannot enter the solution dekstrozy, the risk of seizures, Browning solution |
| Erythromycin | In children the risk of severe convulsions reactions due to slowing down of biotransformation of aminophylline | |
| Amitriptyline | Levodopa | Amplified likelihood gipertoniceski kriza |
| Ampicillin | Β blockers-adrenore- ceptorov (C07) | Increasing the likelihood of anaphylaxis |
| Analgesics, opioid (N2a) | Analeptiki breathing (R07AB, N06BC) | When opioid analgesics (large doses) and respiratory Analeptics may develop seizures |
| Barbiturates (N01AF, N03AA, N05CA, N05CB) | There is a sharp oppression CNS. (Avoid sharing) | |
| MAO inhibitors (N06AF, N06AG, C02KC) | Enhanced by the narcotic effects of opioid analgesics. Parallel to such undesirable effects may occur, as respiratory depression, sharp fluctuations in blood pressure, hyperthermia, loss of consciousness, convulsions | |
| Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA) | Respiratory depression | |
| Anoreksigennye drugs (A08AA) | Cyclic amines (J05ac) | There may be excessive stimulation and initiation of CNS. Rising anti-virus effect |
| Calcium antagonists | Class III antiarrhythmics (C01BD) | The risk of cardiac arrest. (The combination is invalid) |
| Β-adrenoceptor blockers (C07) | There has been a pronounced negative hronotropony (up to heart failure), inotropy (until the development of acute left ventricular failure) and dromotropnyj (up to complete AV block Kady) effect. The likelihood increases dramatically when the original human hearts and intravenous drugs against the background of course receiving β-adrenoceptor blockers. (A dangerous combination, Although its use can be justified in treating rhythm disturbances, severe angina pectoris, Leaky against the backdrop of pronounced tachycardia, not associated with congestive heart failure. Monitoring of marks, conductivity, ČSC. Contraindicated intravenous β-adrenoceptor blocker treatment with Verapamil or vice versa) | |
| Medicines, causing hypokalemia (eg, thiazide diuretics, Amphotericin B, glitches- and Mineralocorticoid *) | Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (Dangerous combination, before applying, you must eliminate hypokaliemia) | |
| Makrolidы (J01FA) | Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated) | |
| Antiepileptic means (N03) | Possibility of development of ventricular fibrillation when combined with intravenous use of Verapamil and dantrolena. (The combination is invalid) | |
| Funds, improving blood flow to organs and tissues (N06BX, N07CA, C04AD, C04AC, A16AX) | Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated) | |
| Calcium antagonists, digidropiridina (C08CA) | Antiarrhythmic drugs (C01B) | Significantly increases the likelihood of ventricular fibrillation. (Combinations should be avoided) |
| Antihypertensive drugs (C02) | Drugs for general anesthesia (N01A) | Joint application may cause insufficience |
| Antihistamines (R06, D04, A07EB, B01AC, R03BC, S016) | Analeptiki breathing (R07AB, N06BC) | Joint application leads to the development of convulsive syndrome |
| Antipsychotic drugs (N05A) | Β-adrenoceptor blockers (C07) | Intensifies the action of β-adrenoceptor blockers. Can develop Sconce- dikardiâ, gipotenziya, increased utom-lâemost′, drowsiness, heart rhythm disturbances, patients receptacles limbs, frequent attacks of bronchial asthma and t. d. Enhanced by the dampening effect of antipsychotics on the central nervous system |
| Anticholinesterases (N07AA, A03F, S01EB) | Muscle relaxants, choline derivatives (M03AB) | It is possible to stop breathing |
| Acetylsalicylic acid | Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA) | Concentrations of tricyclic antidepressants in the blood. There have been cases of deaths at high doses of acetylsalicylic acid on a background of application of the antidepressant imipramine tricikličeskogo |
| Bakampicillin | Β-adrenoceptor blockers (C07) | The likelihood of anaphylaxis |
| Barbiturates (N01AF, N03AA, N05CA, N05CB) | Ergot alkaloids (C04AF, G02AB) | A dangerous rise in blood pressure |
| Analgesics, opioid (N02a) | There is a sharp oppression CNS. (Avoid sharing) | |
| Anxiolytics (N05B) | There is a sharp oppression CNS. (Avoid sharing) | |
| Beklometazon | Indapamid | Large losses of potassium can lead to dangerous arrhythmia |
| Bepridil | Amiodarone | Significantly increases the likelihood of ventricular fibrillation. The risk of cardiac arrest. (The combination is invalid) |
| Amphotericin B | Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (Dangerous combination, before applying you must resolve bepridila hypokaliemia) | |
| Antiarrhythmic pre-paraty (C01B) | Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated) | |
| Β-adrenoceptor blockers (C07) | There has been a pronounced negative hronotropony (up to heart failure), inotropy (until the development of acute left ventricular failure) and dromotropnyi (up to a full m-blockade) effect. The likelihood increases dramatically when the original human hearts and intravenous drugs against the background of course receiving β-adrenoceptor blockers. (A dangerous combination, Although its use can be justified in the treatment of heart rhythm disorders, severe angina pectoris, Leaky against the backdrop of pronounced tachycardia, not associated with congestive heart failure. Monitoring of marks, conductivity, Heart Rate) | |
| Bretili tozilat | Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated) | |
| Vincamine | Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated) | |
| Glucocorticoids (H02AB) | Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (Dangerous combination, before applying you must resolve bepridila hypokaliemia) | |
| Dizopiramid | Significantly increases the likelihood of ventricular fibrillation. The combination is contraindicated | |
| Diuretics thiazide (C03A) | Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (Dangerous combination, before applying you must resolve bepridila hypokaliemia) | |
| Erythromycin/in | Significantly increases the likelihood of ventricular fibrillation. (Combi-power counter) | |
| Β-adrenoceptor blockers (C07) | Selective 5±1 Torah reverse takeover neironalnogo monoaminov (N06AA) | A dangerous drop in blood pressure. (Avoid combination drugs without supervision) |
| Vancomycin | Anesthetic (N01) | The development of erythema, histamine tides and anaphylactic shock. Co-administration may be accompanied by skin flushing |
| Verapamil | Amiodarone | The risk of cardiac arrest. (The combination is invalid) |
| Β-adrenoceptor blockers (C07) | Increased risk of Sconce- dikardii, AY-blockade, gipotonii, Heart Failure. During treatment, Verapamil, you cannot enter r-adrenoceptor blockers intravenously. Observer provides a pronounced negative Chrono- in particular (up to heart failure), ino- in particular (until the development of acute left- Ventricular failure) and dromo- in particular (up to a full AV blockade) effect. The likelihood increases dramatically when the original human hearts and intravenous drugs against the background of course receiving β-blockers. (A dangerous combination, Although its use can be justified in treating rhythm disturbances, severe angina pectoris, Leaky against the backdrop of pronounced tachycardia, not associated with congestive heart failure. Monitoring of marks, conductivity, Heart Rate. Contraindicated intravenous β-blockers in treatment with Verapamil or vice versa) | |
| Halothane | Aminoglikozidy (J01G) | Delves neiromyshecnaya blockade (Perhaps apnea) |
| Lincomycin | Delves neiromyshecnaya blockade (Perhaps apnea) | |
| Polimiksin (J01XB) | Delves neiromyshecnaya blockade (Perhaps apnea) | |
| Ganciclovir | Imipenem | Increases the risk of generalized seizures |
| Cilastatin | Increases the risk of generalized seizures | |
| Gidralazin | Nimodipine | Dangerous decline ad |
| Gidroksizin | Ètinamat | Dangerous reinforcement effects ètinamata. (Avoid combination) |
| Gidroxlortiazid | Selective inhibitors of reverse takeover neironalnogo monoaminov( N06AA) | A dangerous drop in blood pressure. (In the absence of medical supervision to avoid sharing) |
| Nikardeepin | A dangerous drop in blood pressure. (You may want to review doses) | |
| Cardiac glycosides (C01A) | Is enhanced toxicity of cardiac glycosides. Excessive potassium loss causes dangerous heart rhythm disorders | |
| Digitalis glycosides (C01AA) | Hypnotics and sedatives (N05C) | A dangerous block. (Avoid sharing) |
| Dextromethorphan | MAO inhibitors (N06AF, N06AG, C02KC) | Disorientation, heat, fall in blood pressure and loss of consciousness |
| Dextropropoxyphene | Naltrexone | Possible stops breathing, coma and death |
| Digoxin | M-holinoblokatory (N06AF, N06AG, C02KC) | Heart rhythm disturbances. (Dangerous combination) |
| Dizopiramid | Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA) | Development of kardiotoksičeskih effects. Increased risk of ventricular arrhythmias |
| Diltiazem | Amiodarone | The risk of cardiac arrest. (The combination is invalid) |
| Β-adrenoceptor blockers (C07) | Not recommended simultaneous application of β-adrenoceptor blockers and parenteral use of diltiazem. There has been a pronounced negative hronotropony (up to heart failure), inotropy (until the development of left ventricular failure) and dromotropnyj (up to a full m-blockade) effect. The likelihood increases dramatically when the original human hearts and intravenous drugs against the background of course receiving β-adrenoceptor blockers. (A dangerous combination, Although its use can be justified in treating rhythm disturbances, severe angina pectoris, Leaky against the backdrop of pronounced tachycardia, not associated with congestive heart failure. Monitoring of marks, conductivity, Heart Rate) | |
| Cardiac glycosides (C01A) | Combined application of diltiazem with cardiac glycosides may cause violations atrioventrikuliarna conductivity, tissues, ʙradikardiju, heart failure. (While urgent application of diltiazem and cardiac glycosides should take into account the possibility of oppressive actions in the sinus node function. The combination of diltiazem with cardiac glycosides is potentially dangerous) | |
| Quinidine | Increases the risk of arrhythmia | |
| Dioretiki petleve (C03B, C03C) | Ganglioblokatora (C02BC, C02BD) | Possible development orthostatic hypotension |
| Diuretics thiazide (C03A) | Analgesics, opioid (C02BC, C02BD) | Amplified drug effect. There is a sharp oppression CNS |
| Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA) | A dangerous drop in blood pressure. (Avoid combination drugs without supervision) | |
| Doxepin | Preparations, CNS depressants (N05) | Raises the perilous block |
| Dosulepin | Preparations, CNS depressants (N05) | Raises the perilous block |
| Zidovudine | Acyclovir | Lethargy, convulsions |
| Imipramine | Klonidin | The risk of development gipertoniceski kriza |
| Preparations, CNS depressants (N05) | Raises the perilous block. Decreases antidepressant effect | |
| Cimetidine | Possible manifestation of dryness in the mouth, blurred vision, urinary retention, heart palpitations, Orthostatic hypotension, obstilâciâ | |
| MAO inhibitors (N06AF, N06AG, C02KC) | a- и b- adrenomimetiki (R03CA, R03AA, R03DB, S01EA) | The combined use of dangerous, even if adrenomimetiki used as eye drops or drops in the nose. In their joint use may hyper- terézia, hyperthermia, convulsions, death. (The interval between taking drugs for at least two weeks) |
| Analgesics, opioid (N02a) | A dangerous rise in blood pressure. Amplified effects of opioid analgesics — hypotension, respiratory depression | |
| Anoreksigennye drugs (A08AA) | The development of hyperthermia, hypertension, seizures | |
| Antihypertensive drugs (C02) | The development of orthostatic hypotension | |
| MAO inhibitors (N06AF, N06AG, C02KC) | Fever, convulsions, death. (Prohibited use. Taken at intervals of not less than 2 weeks!) | |
| Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA) | Rise in blood pressure to life threatening level. Possible fever, convulsions, delirium. (Prohibited use) | |
| Preparations for iodine therapy (H03c) | Amplified side effects MAO inhibitors. (The combination of these drugs is contraindicated) | |
| Derivatives of phenethylamine (N06BA) | Rise in blood pressure to life threatening level | |
| Indapamid | Amphotericin B | Increases the risk of developing gipokaliemii. (A dangerous combination, shows thorough content correction K+ in blood) |
| Antiarrhythmic drugs (C01B) | Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated) | |
| Bretili tozilat | Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated) | |
| Vincamine | Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated) | |
| Digitalis glycosides | Large losses of potassium can cause cardiac arrhythmia | |
| Glucocorticoids (H02AB) | Increases the risk of developing gipokaliemii. (A dangerous combination, shows thorough content correction K+ in blood) | |
| Dizopiramid | Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated) | |
| Diuretics thiazide (C03A) | Increases the risk of developing gipokaliemii. Amplifies the effect of thiazide diuretic. (Dangerous combination, shows thorough content correction K+ in blood) | |
| Mineralocorticoid (H02AA) | Increases the risk of developing gipokaliemii. (A dangerous combination, shows thorough content correction K+ in blood) | |
| Selective inhibitors of reverse takeover neironalnogo monoamine N06AA) | A dangerous drop in blood pressure | |
| Nikardeepin | A dangerous drop in blood pressure. (Dose should be reviewed) | |
| Nimodipine | A dangerous drop in blood pressure | |
| Itraconazole | Astemizol | Possible cardiac arrest and death. And/or elongate effects astemizola. The risk of arrhythmia. (Avoid sharing) |
| Digoxin | And/or lengthen the effects of Digoxin. Possible poisoning digoxinom | |
| Cyclosporine | Possible poisoning ziklosporinom. And/or elongate effects of Cyclosporine | |
| Ketoconazole | Terfenadin | The risk of developing arrhythmias. Possible cardiac arrest and death. (Unacceptable use) |
| Clomipramine | Analgesics, opioid (N02a) | A dangerous block |
| Preparations, CNS depressants (N05) | A dangerous block | |
| Klonidin | Antipsychotic drugs (N05A) | Hypertonic Kriz (When in/with the introduction of antipsychotics) |
| Β-adrenoceptor blockers (C07) | Increases the risk of bradycardia and AV-blockade. There may be rapid changes in blood pressure | |
| Ètinamat | Dangerous impact ètinamata. (Avoid sharing) | |
| Codeine | Analgesics, opioid (N02a) | A dangerous block. (Avoid simultaneous application) |
| Antihistamines (R06, D04, A07EB, B01AC, R03BC, S016) | A dangerous block. (Avoid match leg application) | |
| Psychotropic drugs (N05, N06) | There might be a dangerous block. (Avoid simultaneous application) | |
| Colchicine | Analgesics, opioid (H02a) | There might be a dangerous block |
| Antihistamines (R06, D04, A07EB, B01AC, R03BC, S016) | There might be a dangerous block | |
| Psychotropic drugs (N05, N06) | There might be a dangerous block | |
| Hypnotics and sedatives (N05C) | There might be a dangerous block | |
| Caffeine | MAO inhibitors (N06AF, N06AG, C02KC) | A dangerous rise in blood pressure |
| Levodopa | MAO inhibitors (N06AF, N06AG, C02KC) | Intensifies the action of MAO inhibitors. Dangerous upgrade HELL. |
| Lidokain | Hexenal | Danger stop breathing |
| Ditilin | Perhaps respiratory depression | |
| Полимиксин B | The on/in the introduction to respiratory depression. Amplified oppression of neuromuscular transmission. (Necessary to monitor the function of the respiratory system of a patient) | |
| Thiopental sodium | Danger stop breathing | |
| Lisinopril | Digitalis glycosides (C01AA) | Excessive potassium loss can demand vocirovat′ heart rhythm |
| Maprotilin | Hypnotics and sedatives (N05C) | There might be a dangerous block |
| Meprobamate | Ètinamat | Strengthening the effectiveness of the dangerous ètinamata. (Avoid sharing) |
| Meproscillarin | Anxiolytics (N05B) | Perhaps the dangerous retardation |
| Preparations, containing potassium (A12B) | An overdose of any drug can cause severe heart rhythm disorders | |
| Hypnotics and sedatives (N05C) | Perhaps the dangerous retardation | |
| Metildigoksin | Hypnotics and sedatives (N05C) | Perhaps the dangerous retardation |
| Methyldopa | Nimodipine | Possible dangerous reduction in blood pressure |
| Organic nitrates (C01DA) | A strong decrease in blood pressure | |
| Drugs for general anesthesia (N01A) | The risk of arterial hypotension. Developed hypotension can be eliminated by means of vazopressornymi, as in the treatment of metildopoj the sensitivity of receptors is saved | |
| Ètinamat | Dangerous impact ètinamata. (Avoid sharing) | |
| Methylprednisolone | Digitalis glycosides | Dangerous potassium level decrease. May increase toxicity digitalisa |
| Indapamid | Large losses of potassium cause dangerous heart rhythm disorders | |
| Metoclopramide | Ètinamat | Dangerous impact ètinamata. (Avoid sharing) |
| Metoprolol | Allergens diagnostic (M01) | Increased risk of severe systemic reactions or anaphylaxis |
| Analgesics, opioid (N02a) | Amplified drug effect. A dangerous block | |
| Verapamil | Simultaneous in/with the introduction of Verapamil can trigger cardiac arrest. Amplifies the effect of both drugs | |
| Methotrexate | Sulfasalazine | Intensifies the toxic effect of medicinal substances. (Avoid sharing) |
| Tetracikliny (J01A) | May increase the toxicity of methotrexate. Increases the absorption of methotrexate from the intestine. Competition for protein and increased methotrexate concentration in blood plasma. (Dangerous combination, requires control of plasma concentration, dose adjustment) | |
| Chloramphenicol | Increases the absorption of methotrexate from the intestine. Intensifies the toxic effect. Competition for protein and increased methotrexate concentration in blood plasma. (Dangerous combination, You must avoid, monitoring plasma concentration, dose adjustment) | |
| Cytostatics (L01, L01AX) | Intensifies the toxic effect. (Dangerous combination, You must avoid) | |
| Moclobemide | a- и b- adrenomimetiki (R03CA, R03AA, R03DB, S01EA) | Upgrade HELL to life threatening level. Intensifies and lengthens effect α- and β-adrainomimetikov |
| Analgesics, opioid (N02a) | Dangerous upgrade HELL | |
| MAO inhibitors (N06AF, N06AG, C02KC) | Fever, convulsions, death. (Unacceptable use) | |
| Levodopa | A sudden and dangerous rise in blood pressure | |
| Maprotilin | A dangerous rise in blood pressure | |
| Methyldopa | A sudden strong ad | |
| Furazolidon | A sudden strong ad | |
| Morphine | Naltrexone | Possible stops breathing, coma and death |
| Moexipril | Digitalis glycosides (C01AA) | The risk of developing arrhythmias. (You need control over the level of potassium in the blood) |
| Naltrexone | Analgesics, opioid (N02a) | Possible stops breathing, coma and death |
| Neselekgivnye inhibitors of reverse takeover neironalnogo monoaminov (N06AA) | Rauwolfia alkaloids (C02AA) | May develop gipertoniceski kriza and/or sharp psychomotor excitation |
| Analgesics, opioid (N02a) | Respiratory depression. Potenciruûtsâ effects of opioid analgesics. (These drugs together should be used with caution and only in small doses) | |
| Antiarrhythmic drugs (C01B) | Possible violation of the institution to the heart muscle, Perhaps the kardiotoksičeskih effects | |
| MAO inhibitors (N06AF, N06AG, C02KC) | Combined application is invalid. Excitation, increased blood pressure, fever, and in severe cases may develop delirium, coma and even come death. These phenomena occur because of intoxication of the organism kateholaminami, that stand out from the bound State under the influence of antidepressants and not inakgiviruûtsâ, Since blocked the activity of enzymes, their destructive. Degree of toxic manifestations is proportional to the dose taken drugs, as between them develops phenomenon expressed the exponentiation. (Antidepressants can only be applied through 1-2 weeks after the end of the admission of MAO inhibitors) | |
| Tireotropona means (H03) | May develop strokes and arrhythmias | |
| Nimodipine | Antihypertensive drugs (C02) | Dangerous drop ad as a result of synergistic actions. (You may want to review dose antigipertenziveh funds) |
| Dizopiramid | Possible heart rhythm | |
| Diuretic (C03) | A dangerous fall in HELL | |
| Nortryptylyn | Analgesics, opioid (N02a) | Raises the perilous block. Amplified drug effect |
| Preparations, CNS depressants (N05) | Raises the perilous block | |
| Furazolidon | A sudden increase in blood pressure | |
| Oxprenolol | Analgesics, opioid (N02a) | Amplified drug effect. A dangerous block |
| Opipramol | Analgesics, opioid (N02a) | A dangerous block |
| Preparations, CNS depressants (N05) | Raises the perilous block | |
| Penbugolol | Analgesics, opioid | Amplified drug effect. A dangerous block |
| Penicillamine | Levamisole | Increases the risk of side effects. (Dangerous combination, It should be avoided) |
| Pyrytramyd | Naltrexone | Possible stops breathing, coma and death. (You should avoid sharing) |
| Prednisolone | Digitalis glycosides (C01AA) | Dangerous potassium level decrease. Possible toxicity glycosides naperstanki |
| Indapamid | Large losses of potassium can lead to dangerous arrhythmia | |
| Prednisone | Indapamid | Large losses of potassium can lead to dangerous arrhythmia |
| Prenilamin | Amiodarone | The risk of cardiac arrest. (The combination is invalid) |
| Β-adrenoceptor blockers (C07) | There has been a pronounced negative hronotropony (up to heart failure), inotropy (until the development of acute left ventricular failure) and dromotropnyj (up to a full AV blockade) effect. The likelihood increases dramatically when the original human hearts and intravenous drugs against the background of course receiving β-adrenoceptor blockers. (A dangerous combination, Although its use can be justified in treating rhythm disturbances, severe angina pectoris, Leaky against the backdrop of pronounced tachycardia, not associated with congestive heart failure. Monitoring of marks, conductivity, CURVES.) | |
| Drugs for general anesthesia (N01A) | a- и b- adrenomimetiki (R03CA, R03AA, R03DB, S01EA) | The joint application is contraindicated due to the possible development of life-threatening heart rhythm disorders |
| Aminoglikozidy (J01G) | May oppression of neuromuscular transmission. During or after anesthesia possible stops breathing | |
| Lincosamides (J01FF) | May oppression of neuromuscular transmission. During or after anesthesia possible stops breathing | |
| Polimiksin (J01XB) | May oppression of neuromuscular transmission. During or after anesthesia possible stops breathing | |
| Drugs krasavki (A03B, A03CB, A03DB, S01FA) | Analgesics (N02) | There is a sharp oppression CNS. (Avoid sharing) |
| Analgesics, opioid (N02a) | There is a sharp oppression CNS. (Avoid sharing) | |
| Anxiolytics (N05B) | There is a sharp oppression CNS. (Avoid sharing) | |
| Hypnotics and sedatives (N05C) | There is a sharp oppression CNS. (Avoid sharing) | |
| Preparations, containing potassium (A12B) | Dioretiki kalisberegate(C03D, C03E) | May develop cardiac arrhythmias or cardiac arrest |
| Probenecid | Analgesics, opioid (N02a) | A dangerous block |
| Antihistamines (R06, D04, A07EB, B01AC, R03BC, S016) | A dangerous block | |
| Psychotropic drugs (N05, N06) | A dangerous block | |
| Prokaynamyd | Aminoglikozidy (J01G) | Possible severe muscle weakness, difficulty breathing |
| Kanamycin | Possible severe muscle weakness, difficulty breathing | |
| Neomycin | Possible severe muscle weakness, difficulty breathing | |
| Procarbazine | MAO inhibitors (N06AF, N06AG, C02KC) | Fever, convulsions, death |
| Levodopa | A sudden strong rise of HELL | |
| Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA) | Upgrade HELL to life threatening level | |
| Derivatives of phenethylamine (N06BA) | Upgrade HELL to life threatening level | |
| Proksibarbal | Analgesics, opioid (N02a) | There might be a dangerous block |
| Anxiolytics (N05B) | There is a sharp oppression CNS | |
| Hypnotics and sedatives (N05C) | There is a sharp oppression CNS | |
| Propranolol | Analgesics, opioid (N02a) | Amplified drug effect. A dangerous block |
| Ramipril | Digitalis glycosides (C01AA) | The risk of arrhythmia. You need control over the level of potassium in the blood |
| Reserpine | Corticosteroids for system application H02 (H02) | Large losses of potassium cause dangerous heart rhythm disorders. Gipotenzivny effect is reduced due to delays of potassium and water |
| Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA) | May develop gipertoniceski kriza and/or sharp psychomotor excitation | |
| Nimodipine | Dangerous decline ad | |
| Organic nitrates (C01DA) | Strong decline ad | |
| Psychotropic drugs (N05, N06) | There is a sharp oppression CNS | |
| Salicylic acid and its derivatives (N02 VA) | Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA) | Combined use of dangerous. Cases of death |
| Selegiline | Analgesics, opioid (N02a) | Severe toxic reaction, convulsions, coma and death |
| Cardiac glycosides (C01A) | Preparations, containing calcium (A12A) | Intravenous drugs, containing calcium, patients, receiving cardiac glycosides, dangerous, because it could lead to the development of severe heart rhythm disorders |
| Scopolamine | Ètinamat | Dangerous impact ètinamata. (Avoid sharing) |
| Hypnotics and sedatives (N05C) | Analeptiki breathing (R07AB, N06BC) | Respiratory analeptic poisoning used hypnotics and sedatives. However, it should be remembered, that in severe poisoning of hypnotics and sedatives application analeptikov undesirable, because in this case, exploding a mismatch between demand and supply of oxygen to the tissues |
| Spironolakgon | Amiloride | Dangerous potassium delay. The risk of arrhythmia |
| Nimodipine | Dangerously declining AD | |
| Triamterene | Dangerous potassium delay. The risk of arrhythmia | |
| Funds, improve tone and oxytocics activity oxytocics (G02A) | The combined use of ergometrine and dopamine; oxytocin and ergot alkaloids is dangerous | |
| Strophanthin K | Anxiolytics (N05B) | Perhaps the dangerous retardation |
| Hypnotics and sedatives (N05C) | Perhaps the dangerous retardation | |
| Sufentanil | Naltrexone | Possible stops breathing, coma and death |
| Terazosin | Nimodipine | Dangerous decline ad |
| Tilidine | Naltrexone | Possible stops breathing, coma and death |
| Thiopental sodium | Sulfonamides (J01EB, J01EC, J01ED) | Danger stop breathing |
| Triamterene | Amiloride | Dangerous rise in the level of potassium in the blood |
| Antidepressants (N06A) | A dangerous fall in HELL. (Without supervision to avoid sharing) | |
| Digitalis glycosides (C01AA) | Decreases toxicity glycosides naperstanki. (You need control over the level of potassium in the blood) | |
| Corticosteroids for system application H02 (H02) | Severe potassium loss causes dangerous heart rhythm disorders | |
| Nikardeepin | A dangerous drop in blood pressure. (Needed correction doses) | |
| Nimodipine | A dangerous fall in HELL | |
| Organic nitrates (C01DA) | The strong fall in HELL | |
| Spironolakgon | Dangerous rise in the level of potassium in the blood | |
| Triamcinolone | Digitalis glycosides (C01AA) | Dangerous reduction in the level of potassium in the blood plasma |
| Trimipramine | Preparations, CNS depressants (N05) | Raises the perilous block |
| Hypnotics and sedatives (N05C) | Raises the perilous block | |
| Phenobarbital | Analgesics, opioid (N02a) | A dangerous block. (Avoid simultaneous application) |
| Psychotropic drugs (N05, N06) | A dangerous block. (Avoid simultaneous application) | |
| Phenothiazine derivatives (N05AA, N05AB, N05AC) | Α-adrenoceptor blockers (C02CA) | Intensifies the action of α-adrenoceptor Blocker. Can develop bradycardia, gipotenziya, fatigue, drowsiness, heart rhythm disturbances, patients receptacles limbs, frequent attacks of bronchial asthma and t. d. Amplified a dampening effect on the central nervous system derivatives fenotiazina |
| Β blockers- adrenoreceptorov (C07) | Bradycardia, gipotenziya, fatigue, drowsiness, Cardiac arrhythmia, patients receptacles limbs, frequent attacks of bronchial asthma, etc. | |
| Flavoksat | Ètinamat | Dangerous impact ètinamata. (Avoid sharing) |
| Flunitrazepam | Psychotropic drugs (N05, N06) | Development status of anxiety of excitation, ajitation and socially dangerous behaviour with subsequent amnesia |
| Fluoxetine | Antithrombotics (B01a) | Confusion, excitation, convulsions, the rise of HELL due to increased plasma concentrations of fluoxetine |
| Digitalis glycosides (C01AA) | Confusion, excitation, convulsions, upgrade HELL | |
| MAO inhibitors (N06AF, N06AG, C02KC) | Confusion, excitation, convulsions, upgrade HELL. (The combination is contraindicated) | |
| Fotemûstin | Dakarʙazin | There have been cases of toxic effects on the part of the respiratory system (respiratory distress syndrome, adult) |
| Quinidine | b- adrenomimetiki (G02CA, R03AB, R03AC, R03CB, R03CC) | There is a risk of development of gross violations heart rhythm |
| Anticholinesterases (N07AA, A03F, S01EB) | The development of atrial fibrillation the ventricles of the heart | |
| Quinones | Risk of poisoning increases hinidine against the backdrop of quinine | |
| Chloral hydrate | Ètinamat | Dangerous impact ètinamata. (Avoid sharing) |
| Xlortalidon | Glucocorticoids (H02AB) | Severe potassium loss lead to dangerous arrhythmia |
| Corticosteroids for system application H02 (H02) | Severe potassium loss lead to dangerous arrhythmia | |
| Neselekgivnye inhibitors of reverse takeover neironalnogo monoaminov (N06AA) | A dangerous drop in blood pressure. (Avoid sharing without supervision) | |
| Cisapride | Substances, metaboliziruûŝiesâ with the help of the enzyme zitohroma P450 | Increased concentrations of cisapride in plasma, and increases the risk of fatal arrhythmias |
| Itraconazole | Increased concentrations of cisapride in plasma, and increases the risk of fatal arrhythmias | |
| Ketoconazole | Increased concentrations of cisapride in plasma, and increases the risk of fatal arrhythmias | |
| Clarithromycin | Increased concentrations of cisapride in plasma, and increases the risk of fatal arrhythmias | |
| Mikonazol | Increased concentrations of cisapride in plasma, and increases the risk of fatal arrhythmias | |
| Fluconazole | Increased concentrations of cisapride in plasma, and increases the risk of development of fatal arrhythmias | |
| Erythromycin | Increased concentrations of cisapride and blood plasma, and increases the risk of fatal arrhythmias | |
| Circular amines (J05ac) | Anoreksigennye drugs (A08AA) | There may be excessive stimulation and initiation of CNS. Rising anti-virus effect |
| Cyclobarbital | Analgesics, opioid (N02a) | There might be a dangerous block |
| Psychotropic drugs (N05, N06)
| A dangerous block. (Avoid simultaneous application) | |
| Cyclosporine | Aminoglikozidy (J01G) | Increases nefrotoksicnosti. (Dangerous combination, You must avoid) |
| Amphotericin B | Increases nefrotoksicnosti. (Dangerous combination, You must avoid) | |
| Calcium antagonists (C08) | Increases plasma concentration. (Dangerous combination, If possible, it is necessary to avoid; need monitoring plasma concentration, dose adjustment) | |
| Hormonal contraceptives (G03A) | Increases plasma concentration of Cyclosporine. (Dangerous combination, If possible, it is necessary to avoid; need monitoring plasma concentration, dose adjustment) | |
| HMG-CoA reductase inhibitors (C10AA) | Myo, muscular weakness. (Dangerous combination, You must avoid) | |
| Ketoconazole | Slows inachtiwatia Cyclosporine, that leads to an increase in its concentration in the blood plasma and the frequency of side effects. (Dangerous combination. There is a need to avoid sharing) | |
| Colchicine | Increases nefrotoksicnosti. Myo, muscular weakness. (Dangerous combination; You must avoid) | |
| Lovastatin | Dangerous combination, giving rise to acute renal failure. (There is a need to avoid sharing) | |
| Makrolidы (J01FA) | Increases plasma concentration (Dangerous combination, If possible, it is necessary to avoid; need monitoring plasma concentration, dose adjustment) | |
| Melfalane | Increases nefrotoksicnosti. (Dangerous combination, You must avoid) | |
| NSAIDs (M01A, M01V) | Increases nefrotoksicnosti. (Dangerous combination, You must avoid) | |
| Prednisolone | Increases plasma concentration of Cyclosporine, and reduced clearance of prednisone. (Dangerous combination, If possible, it is necessary to avoid; need monitoring plasma concentration, dose adjustment) | |
| Propafenone | Increases plasma concentration. (Dangerous combination, If possible, it is necessary to avoid; need monitoring plasma concentration, dose adjustment) | |
| Trimethoprim | Increases nefrotoksicnosti. (Dangerous combination, You must avoid) | |
| Ciprofloxacin | Increases nefrotoksicnosti. (Dangerous combination, You must avoid) | |
| Erythromycin | Increases the concentration of Cyclosporine in the blood plasma. (Dangerous combination. There is a need to avoid sharing or make a correction dose) | |
| Cimetidine | Morphine | Respiratory depression |
| Fentanyl | Respiratory depression | |
| Enalapril | Digitalis glycosides (C01AA) | You need control over the level of potassium in the blood |
| Epinephrine | Norepinephrine | Heart rhythm disturbances, hypertension and even death |
| Ergotamin | Analgesics (N02) | A dangerous block. (Avoid simultaneous reception) |
| Antihistamines (R06, D04, A07EB, B01AC, R03BC, S016) | A dangerous block. (Avoid sharing) | |
| Fenilzgilamina derivatives (N06BA) | Dangerous upgrade HELL | |
| Pseudoephedrine | Dangerous upgrade HELL | |
| Psychotropic drugs (N05, N06) | A dangerous block. (Avoid simultaneous reception) | |
| Epinephrine | Dangerous upgrade HELL | |
| Ephedrine | Dangerous upgrade HELL | |
