Dangerous drug interactions, which may result in hospitalization or death

 

Particularly dangerous and lethal combination of drugs

Drug or group of drugs

Drug or group of drugs

Cooperation (recommendations, notes)

a- и b- adrenomimetiki (R03CA, R03AA, R03DB, S01EA)a- и b- adrenomimetiki (R01AA, R01AB)Dangerous heart rhythm disorders, severe hypertension, possible death
MAO inhibitors (N06AF, N06AB, C02KC)Joint application of α- и b- adrenomimetikov and MAO inhibitors is dangerous, even if adrenomimetiki applied in the form of eye drops (klonidin, guanfaцin, moxonidine improve sensitivity to kateholaminam, and MAO inhibitors lead to the accumulation of past). In their joint application possible hypertension, hyperthermia, convulsions, death (The interval between taking drugs for at least two weeks)
Drugs for general anesthesia (N01A)Combined use not recommended, as may develop life-threatening heart rhythm disorders
b- adrenomimetiki (G02CA, R03AB, R03AC, R03CB, R03CC)Glucocorticoids (H02AB)Joint application of r-adrenomimetikov and glucocorticoids in late pregnancy may lead to the development of pulmonary edema in the mother
AzathioprineMielodepressanta *Intensifies the toxic effect. (Dangerous combination, You must avoid)
NSAIDs, Butilpirazolidiny (M01AA)Intensifies the toxic effect. (Dangerous combination, You must avoid)
SalazopiridazinAmplified toxic effect azatioprina. (Dangerous combination, You must avoid)
Suxamethonium chloridePotentiated neiromyshecnaya blockade. (Dangerous combination, You must take into account)
Sulfonamides (J01EB, J01EC, J01ED)Intensifies the toxic effect. (Dangerous combination, You must avoid)
ChloramphenicolIntensifies the toxic effect. (Dangerous combination, You must avoid)
Cytostatics (L01, L01AX)Intensifies the toxic effect. (Dangerous combination, You must avoid)
Rauwolfia alkaloids (C02AA)Alkogol′soderžaŝie drugsJoint application may cause ortostaticeski collapse
Α-adrenoceptor blockers (C02CA)Joint application may cause ortostaticeski collapse
AlьfuzozinAntihypertensive drugs (C02)If you are applying to al′fuzozina with antigipertenzivei drugs (especially calcium channel blockers) perhaps marked reduction of blood pressure, until the development of collapse (!)
AmantadinGidroxlortiazidIntensifies the toxic effect of midantana (traffic violation, hallucinations: delirium, vision, purchasing reality)
TriamtereneIntensifies the toxic effect of midantana (traffic violation, gallûcina-tion, delirium)
AminofillinDextroseAminophylline, you cannot enter the solution dekstrozy, the risk of seizures, Browning solution
ErythromycinIn children the risk of severe convulsions reactions due to slowing down of biotransformation of aminophylline
AmitriptylineLevodopaAmplified likelihood gipertoniceski kriza
AmpicillinΒ blockers-adrenore- ceptorov (C07)Increasing the likelihood of anaphylaxis
Analgesics, opioid (N2a)Analeptiki breathing (R07AB, N06BC)When opioid analgesics (large doses) and respiratory Analeptics may develop seizures
Barbiturates (N01AF, N03AA, N05CA, N05CB)There is a sharp oppression CNS. (Avoid sharing)
MAO inhibitors (N06AF, N06AG, C02KC)Enhanced by the narcotic effects of opioid analgesics. Parallel to such undesirable effects may occur, as respiratory depression, sharp fluctuations in blood pressure, hyperthermia, loss of consciousness, convulsions
Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA)Respiratory depression
Anoreksigennye drugs (A08AA)Cyclic amines (J05ac)There may be excessive stimulation and initiation of CNS. Rising anti-virus effect
Calcium antagonistsClass III antiarrhythmics (C01BD)The risk of cardiac arrest. (The combination is invalid)
Β-adrenoceptor blockers (C07)There has been a pronounced negative hronotropony (up to heart failure), inotropy (until the development of acute left ventricular failure) and dromotropnyj (up to complete AV block Kady) effect. The likelihood increases dramatically when the original human hearts and intravenous drugs against the background of course receiving β-adrenoceptor blockers. (A dangerous combination, Although its use can be justified in treating rhythm disturbances, severe angina pectoris, Leaky against the backdrop of pronounced tachycardia, not associated with congestive heart failure. Monitoring of marks, conductivity, ČSC. Contraindicated intravenous β-adrenoceptor blocker treatment with Verapamil or vice versa)
Medicines, causing hypokalemia (eg, thiazide diuretics, Amphotericin B, glitches- and Mineralocorticoid *)Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (Dangerous combination, before applying, you must eliminate hypokaliemia)
Makrolidы (J01FA)Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated)
Antiepileptic means (N03)Possibility of development of ventricular fibrillation when combined with intravenous use of Verapamil and dantrolena. (The combination is invalid)
Funds, improving blood flow to organs and tissues (N06BX, N07CA, C04AD, C04AC, A16AX)Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated)
Calcium antagonists, digidropiridina (C08CA)Antiarrhythmic drugs (C01B)Significantly increases the likelihood of ventricular fibrillation. (Combinations should be avoided)
Antihypertensive drugs (C02)Drugs for general anesthesia (N01A)Joint application may cause insufficience
Antihistamines (R06, D04, A07EB, B01AC, R03BC, S016)Analeptiki breathing (R07AB, N06BC)Joint application leads to the development of convulsive syndrome
Antipsychotic drugs (N05A)Β-adrenoceptor blockers (C07)Intensifies the action of β-adrenoceptor blockers. Can develop Sconce- dikardiâ, gipotenziya, increased utom-lâemost′, drowsiness, heart rhythm disturbances, patients receptacles limbs, frequent attacks of bronchial asthma and t. d.

Enhanced by the dampening effect of antipsychotics on the central nervous system

Anticholinesterases

(N07AA, A03F, S01EB)

Muscle relaxants, choline derivatives (M03AB)It is possible to stop breathing
Acetylsalicylic acidSelective inhibitors of reverse takeover neironalnogo monoaminov (N06AA)Concentrations of tricyclic antidepressants in the blood. There have been cases of deaths at high doses of acetylsalicylic acid on a background of application of the antidepressant imipramine tricikličeskogo
BakampicillinΒ-adrenoceptor blockers (C07)The likelihood of anaphylaxis
Barbiturates (N01AF, N03AA, N05CA, N05CB)Ergot alkaloids (C04AF, G02AB)A dangerous rise in blood pressure
Analgesics, opioid (N02a)There is a sharp oppression CNS. (Avoid sharing)
Anxiolytics (N05B)There is a sharp oppression CNS. (Avoid sharing)
BeklometazonIndapamidLarge losses of potassium can lead to dangerous arrhythmia
BepridilAmiodaroneSignificantly increases the likelihood of ventricular fibrillation. The risk of cardiac arrest. (The combination is invalid)
Амфотерицин BIncreases the likelihood of ventricular tachycardia and ventricular fibrillation. (Dangerous combination, before applying you must resolve bepridila hypokaliemia)
Antiarrhythmic pre-paraty (C01B)Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated)
Β-adrenoceptor blockers (C07)There has been a pronounced negative hronotropony (up to heart failure), inotropy (until the development of acute left ventricular failure) and dromotropnyi (up to a full m-blockade) effect. The likelihood increases dramatically when the original human hearts and intravenous drugs against the background of course receiving β-adrenoceptor blockers. (A dangerous combination, Although its use can be justified in the treatment of heart rhythm disorders, severe angina pectoris, Leaky against the backdrop of pronounced tachycardia, not associated with congestive heart failure. Monitoring of marks, conductivity, Heart Rate)
Bretili tozilatSignificantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated)
VincamineSignificantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated)
Glucocorticoids (H02AB)Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (Dangerous combination, before applying you must resolve bepridila hypokaliemia)
DizopiramidSignificantly increases the likelihood of ventricular fibrillation. The combination is contraindicated
Diuretics thiazide (C03A)Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (Dangerous combination, before applying you must resolve bepridila hypokaliemia)
Erythromycin/inSignificantly increases the likelihood of ventricular fibrillation. (Combi-power counter)
Β-adrenoceptor blockers (C07)Selective 5±1 Torah reverse takeover neironalnogo monoaminov (N06AA)A dangerous drop in blood pressure. (Avoid combination drugs without supervision)
VancomycinAnesthetic (N01)The development of erythema, histamine tides and anaphylactic shock. Co-administration may be accompanied by skin flushing
VerapamilAmiodaroneThe risk of cardiac arrest. (The combination is invalid)
Β-adrenoceptor blockers (C07)Increased risk of Sconce- dikardii, AY-blockade, gipotonii, Heart Failure. During treatment, Verapamil, you cannot enter r-adrenoceptor blockers intravenously. Observer provides a pronounced negative Chrono- in particular (up to heart failure), ino- in particular (until the development of acute left- Ventricular failure) and dromo- in particular (up to a full AV blockade) effect. The likelihood increases dramatically when the original human hearts and intravenous drugs against the background of course receiving β-blockers. (A dangerous combination, Although its use can be justified in treating rhythm disturbances, severe angina pectoris, Leaky against the backdrop of pronounced tachycardia, not associated with congestive heart failure. Monitoring of marks, conductivity, Heart Rate. Contraindicated intravenous β-blockers in treatment with Verapamil or vice versa)
HalothaneAminoglikozidy (J01G)Delves neiromyshecnaya blockade (Perhaps apnea)
LincomycinDelves neiromyshecnaya blockade (Perhaps apnea)
Polimiksin (J01XB)Delves neiromyshecnaya blockade (Perhaps apnea)
GanciclovirImipenemIncreases the risk of generalized seizures
CilastatinIncreases the risk of generalized seizures
GidralazinNimodipineDangerous decline ad
GidroksizinÈtinamatDangerous reinforcement effects ètinamata. (Avoid combination)
GidroxlortiazidSelective inhibitors of reverse takeover neironalnogo monoaminov( N06AA)A dangerous drop in blood pressure. (In the absence of medical supervision to avoid sharing)
NikardeepinA dangerous drop in blood pressure. (You may want to review doses)
Cardiac glycosides (C01A)Is enhanced toxicity of cardiac glycosides. Excessive potassium loss causes dangerous heart rhythm disorders
Digitalis glycosides (C01AA)Hypnotics and sedatives (N05C)A dangerous block. (Avoid sharing)
DextromethorphanMAO inhibitors (N06AF, N06AG, C02KC)Disorientation, heat, fall in blood pressure and loss of consciousness
DextropropoxypheneNaltrexonePossible stops breathing, coma and death
DigoxinM-holinoblokatory (N06AF, N06AG, C02KC)Heart rhythm disturbances. (Dangerous combination)
DizopiramidSelective inhibitors of reverse takeover neironalnogo monoaminov (N06AA)Development of kardiotoksičeskih effects. Increased risk of ventricular arrhythmias
DiltiazemAmiodaroneThe risk of cardiac arrest. (The combination is invalid)
Β-adrenoceptor blockers (C07)Not recommended simultaneous application of β-adrenoceptor blockers and parenteral use of diltiazem. There has been a pronounced negative hronotropony (up to heart failure), inotropy (until the development of left ventricular failure) and dromotropnyj (up to a full m-blockade) effect. The likelihood increases dramatically when the original human hearts and intravenous drugs against the background of course receiving β-adrenoceptor blockers. (A dangerous combination, Although its use can be justified in treating rhythm disturbances, severe angina pectoris, Leaky against the backdrop of pronounced tachycardia, not associated with congestive heart failure. Monitoring of marks, conductivity, Heart Rate)
Cardiac glycosides (C01A)Combined application of diltiazem with cardiac glycosides may cause violations atrioventrikuliarna conductivity, tissues, ʙradikardiju, heart failure. (While urgent application of diltiazem and cardiac glycosides should take into account the possibility of oppressive actions in the sinus node function. The combination of diltiazem with cardiac glycosides is potentially dangerous)
QuinidineIncreases the risk of arrhythmia
Dioretiki petleve (C03B, C03C)Ganglioblokatora (C02BC, C02BD)Possible development orthostatic hypotension
Diuretics thiazide (C03A)Analgesics, opioid (C02BC, C02BD)Amplified drug effect. There is a sharp oppression CNS
Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA)A dangerous drop in blood pressure. (Avoid combination drugs without supervision)
DoxepinPreparations, CNS depressants (N05)Raises the perilous block
DosulepinPreparations, CNS depressants (N05)Raises the perilous block
ZidovudineAcyclovirLethargy, convulsions
ImipramineKlonidinThe risk of development gipertoniceski kriza
Preparations, CNS depressants (N05)Raises the perilous block. Decreases antidepressant effect
CimetidinePossible manifestation of dryness in the mouth, blurred vision, urinary retention, heart palpitations, Orthostatic hypotension, obstilâciâ
MAO inhibitors (N06AF, N06AG, C02KC)a- и b- adrenomimetiki (R03CA, R03AA, R03DB, S01EA)The combined use of dangerous, even if adrenomimetiki used as eye drops or drops in the nose. In their joint use may hyper- terézia, hyperthermia, convulsions, death. (The interval between taking drugs for at least two weeks)
Analgesics, opioid (N02a)A dangerous rise in blood pressure. Amplified effects of opioid analgesics — hypotension, respiratory depression
Anoreksigennye drugs (A08AA)The development of hyperthermia, hypertension, seizures
Antihypertensive drugs (C02)The development of orthostatic hypotension
MAO inhibitors (N06AF, N06AG, C02KC)Fever, convulsions, death. (Prohibited use. Taken at intervals of not less than 2 weeks!)
Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA)Rise in blood pressure to life threatening level. Possible fever, convulsions, delirium. (Prohibited use)
Preparations for iodine therapy (H03c)Amplified side effects MAO inhibitors. (The combination of these drugs is contraindicated)
Derivatives of phenethylamine (N06BA)Rise in blood pressure to life threatening level
IndapamidАмфотерицин BIncreases the risk of developing gipokaliemii. (A dangerous combination, shows thorough content correction K+ in blood)
Antiarrhythmic drugs (C01B)Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated)
Bretili tozilatSignificantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated)
VincamineSignificantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated)
Digitalis glycosidesLarge losses of potassium can cause cardiac arrhythmia
Glucocorticoids (H02AB)Increases the risk of developing gipokaliemii. (A dangerous combination, shows thorough content correction K+ in blood)
DizopiramidSignificantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated)
Diuretics thiazide (C03A)Increases the risk of developing gipokaliemii. Amplifies the effect of thiazide diuretic. (Dangerous combination, shows thorough content correction K+ in blood)
Mineralocorticoid (H02AA)Increases the risk of developing gipokaliemii. (A dangerous combination, shows thorough content correction K+ in blood)
Selective inhibitors of reverse takeover neironalnogo monoamine N06AA)A dangerous drop in blood pressure
NikardeepinA dangerous drop in blood pressure. (Dose should be reviewed)
NimodipineA dangerous drop in blood pressure
ItraconazoleAstemizolPossible cardiac arrest and death. And/or elongate effects astemizola. The risk of arrhythmia. (Avoid sharing)
DigoxinAnd/or lengthen the effects of Digoxin. Possible poisoning digoxinom
CyclosporinePossible poisoning ziklosporinom. And/or elongate effects of Cyclosporine
KetoconazoleTerfenadinThe risk of developing arrhythmias. Possible cardiac arrest and death. (Unacceptable use)
ClomipramineAnalgesics, opioid (N02a)A dangerous block
Preparations, CNS depressants (N05)A dangerous block
KlonidinAntipsychotic drugs (N05A)Hypertonic Kriz (When in/with the introduction of antipsychotics)
Β-adrenoceptor blockers (C07)Increases the risk of bradycardia and AV-blockade. There may be rapid changes in blood pressure
ÈtinamatDangerous impact ètinamata. (Avoid sharing)
CodeineAnalgesics, opioid (N02a)A dangerous block. (Avoid simultaneous application)
Antihistamines (R06, D04, A07EB, B01AC, R03BC, S016)A dangerous block. (Avoid match leg application)
Psychotropic drugs (N05, N06)There might be a dangerous block. (Avoid simultaneous application)
ColchicineAnalgesics, opioid (H02a)There might be a dangerous block
Antihistamines (R06, D04, A07EB, B01AC, R03BC, S016)There might be a dangerous block
Psychotropic drugs (N05, N06)There might be a dangerous block
Hypnotics and sedatives

(N05C)

There might be a dangerous block
CaffeineMAO inhibitors (N06AF, N06AG, C02KC)A dangerous rise in blood pressure
LevodopaMAO inhibitors (N06AF, N06AG, C02KC)Intensifies the action of MAO inhibitors. Dangerous upgrade HELL.
LidokainHexenalDanger stop breathing
DitilinPerhaps respiratory depression
Полимиксин BThe on/in the introduction to respiratory depression. Amplified oppression of neuromuscular transmission. (Necessary to monitor the function of the respiratory system of a patient)
Thiopental sodiumDanger stop breathing
LisinoprilDigitalis glycosides (C01AA)Excessive potassium loss can demand vocirovat′ heart rhythm
MaprotilinHypnotics and sedatives (N05C)There might be a dangerous block
MeprobamateÈtinamatStrengthening the effectiveness of the dangerous ètinamata. (Avoid sharing)
MeproscillarinAnxiolytics (N05B)Perhaps the dangerous retardation
Preparations, containing potassium (A12B)An overdose of any drug can cause severe heart rhythm disorders
Hypnotics and sedatives (N05C)Perhaps the dangerous retardation
MetildigoksinHypnotics and sedatives (N05C)Perhaps the dangerous retardation
MethyldopaNimodipinePossible dangerous reduction in blood pressure
Organic nitrates (C01DA)A strong decrease in blood pressure
Drugs for general anesthesia (N01A)The risk of arterial hypotension. Developed hypotension can be eliminated by means of vazopressornymi, as in the treatment of metildopoj the sensitivity of receptors is saved
ÈtinamatDangerous impact ètinamata. (Avoid sharing)
MethylprednisoloneDigitalis glycosidesDangerous potassium level decrease. May increase toxicity digitalisa
IndapamidLarge losses of potassium cause dangerous heart rhythm disorders
MetoclopramideÈtinamatDangerous impact ètinamata. (Avoid sharing)
MetoprololAllergens diagnostic (M01)Increased risk of severe systemic reactions or anaphylaxis
Analgesics, opioid (N02a)Amplified drug effect. A dangerous block
VerapamilSimultaneous in/with the introduction of Verapamil can trigger cardiac arrest. Amplifies the effect of both drugs
MethotrexateSulfasalazineIntensifies the toxic effect of medicinal substances. (Avoid sharing)
Tetracikliny (J01A)May increase the toxicity of methotrexate. Increases the absorption of methotrexate from the intestine.

Competition for protein and increased methotrexate concentration in blood plasma. (Dangerous combination, requires control of plasma concentration, dose adjustment)

ChloramphenicolIncreases the absorption of methotrexate from the intestine.

Intensifies the toxic effect. Competition for protein and increased methotrexate concentration in blood plasma. (Dangerous combination, You must avoid, monitoring plasma concentration, dose adjustment)

Cytostatics (L01, L01AX)Intensifies the toxic effect. (Dangerous combination, You must avoid)
Moclobemidea- и b- adrenomimetiki (R03CA, R03AA, R03DB, S01EA)Upgrade HELL to life threatening level. Intensifies and lengthens effect α- and β-adrainomimetikov
Analgesics, opioid (N02a)Dangerous upgrade HELL
MAO inhibitors (N06AF, N06AG, C02KC)Fever, convulsions, death. (Unacceptable use)
LevodopaA sudden and dangerous rise in blood pressure
MaprotilinA dangerous rise in blood pressure
MethyldopaA sudden strong ad
FurazolidonA sudden strong ad
MorphineNaltrexonePossible stops breathing, coma and death
MoexiprilDigitalis glycosides (C01AA)The risk of developing arrhythmias. (You need control over the level of potassium in the blood)
NaltrexoneAnalgesics, opioid (N02a)Possible stops breathing, coma and death
Neselekgivnye inhibitors of reverse takeover neironalnogo monoaminov (N06AA)Rauwolfia alkaloids (C02AA)May develop gipertoniceski kriza and/or sharp psychomotor excitation
Analgesics, opioid

(N02a)

Respiratory depression. Potenciruûtsâ effects of opioid analgesics. (These drugs together should be used with caution and only in small doses)
Antiarrhythmic drugs (C01B)Possible violation of the institution to the heart muscle, Perhaps the kardiotoksičeskih effects
MAO inhibitors (N06AF, N06AG, C02KC)Combined application is invalid. Excitation, increased blood pressure, fever, and in severe cases may develop delirium, coma and even come death. These phenomena occur because of intoxication of the organism kateholaminami, that stand out from the bound State under the influence of antidepressants and not inakgiviruûtsâ, Since blocked the activity of enzymes, their destructive. Degree of toxic manifestations is proportional to the dose taken drugs, as between them develops phenomenon expressed the exponentiation. (Antidepressants can only be applied through 1-2 weeks after the end of the admission of MAO inhibitors)
Tireotropona means (H03)May develop strokes and arrhythmias
NimodipineAntihypertensive drugs (C02)Dangerous drop ad as a result of synergistic actions. (You may want to review dose antigipertenziveh funds)
DizopiramidPossible heart rhythm
Diuretic (C03)A dangerous fall in HELL
NortryptylynAnalgesics, opioid (N02a)Raises the perilous block. Amplified drug effect
Preparations, CNS depressants (N05)Raises the perilous block
FurazolidonA sudden increase in blood pressure
OxprenololAnalgesics, opioid (N02a)Amplified drug effect. A dangerous block
OpipramolAnalgesics, opioid (N02a)A dangerous block
Preparations, CNS depressants (N05)Raises the perilous block
PenbugololAnalgesics, opioidAmplified drug effect. A dangerous block
PenicillamineLevamisoleIncreases the risk of side effects. (Dangerous combination, It should be avoided)
PyrytramydNaltrexonePossible stops breathing, coma and death. (You should avoid sharing)
PrednisoloneDigitalis glycosides (C01AA)Dangerous potassium level decrease. Possible toxicity glycosides naperstanki
IndapamidLarge losses of potassium can lead to dangerous arrhythmia
PrednisoneIndapamidLarge losses of potassium can lead to dangerous arrhythmia
PrenilaminAmiodaroneThe risk of cardiac arrest. (The combination is invalid)
Β-adrenoceptor blockers (C07)There has been a pronounced negative hronotropony (up to heart failure), inotropy (until the development of acute left ventricular failure) and dromotropnyj (up to a full AV blockade) effect. The likelihood increases dramatically when the original human hearts and intravenous drugs against the background of course receiving β-adrenoceptor blockers. (A dangerous combination, Although its use can be justified in treating rhythm disturbances, severe angina pectoris, Leaky against the backdrop of pronounced tachycardia, not associated with congestive heart failure. Monitoring of marks, conductivity, CURVES.)
Drugs for general anesthesia (N01A)a- и b- adrenomimetiki (R03CA, R03AA, R03DB, S01EA)The joint application is contraindicated due to the possible development of life-threatening heart rhythm disorders
Aminoglikozidy (J01G)May oppression of neuromuscular transmission. During or after anesthesia possible stops breathing
Lincosamides (J01FF)May oppression of neuromuscular transmission. During or after anesthesia possible stops breathing
Polimiksin (J01XB)May oppression of neuromuscular transmission. During or after anesthesia possible stops breathing
Drugs krasavki (A03B, A03CB, A03DB, S01FA)Analgesics (N02)There is a sharp oppression CNS. (Avoid sharing)
Analgesics, opioid

(N02a)

There is a sharp oppression CNS. (Avoid sharing)
Anxiolytics (N05B)There is a sharp oppression CNS. (Avoid sharing)
Hypnotics and sedatives (N05C)There is a sharp oppression CNS. (Avoid sharing)
Preparations, containing potassium (A12B)Dioretiki kalisberegate(C03D, C03E)May develop cardiac arrhythmias or cardiac arrest
ProbenecidAnalgesics, opioid (N02a)A dangerous block
Antihistamines (R06, D04, A07EB, B01AC, R03BC, S016)A dangerous block
Psychotropic drugs (N05, N06)A dangerous block
ProkaynamydAminoglikozidy (J01G)Possible severe muscle weakness, difficulty breathing
KanamycinPossible severe muscle weakness, difficulty breathing
NeomycinPossible severe muscle weakness, difficulty breathing
ProcarbazineMAO inhibitors (N06AF, N06AG, C02KC)Fever, convulsions, death
LevodopaA sudden strong rise of HELL
Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA)Upgrade HELL to life threatening level
Derivatives of phenethylamine (N06BA)Upgrade HELL to life threatening level
ProksibarbalAnalgesics, opioid (N02a)There might be a dangerous block
Anxiolytics (N05B)There is a sharp oppression CNS
Hypnotics and sedatives

(N05C)

There is a sharp oppression CNS
PropranololAnalgesics, opioid (N02a)Amplified drug effect. A dangerous block
RamiprilDigitalis glycosides (C01AA)The risk of arrhythmia. You need control over the level of potassium in the blood
ReserpineCorticosteroids for system application H02 (H02)Large losses of potassium cause dangerous heart rhythm disorders. Gipotenzivny effect is reduced due to delays of potassium and water
Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA)May develop gipertoniceski kriza and/or sharp psychomotor excitation
NimodipineDangerous decline ad
Organic nitrates (C01DA)Strong decline ad
Psychotropic drugs (N05, N06)There is a sharp oppression CNS
Salicylic acid and its derivatives (N02 VA)Selective inhibitors of reverse takeover neironalnogo monoaminov (N06AA)Combined use of dangerous. Cases of death
SelegilineAnalgesics, opioid (N02a)Severe toxic reaction, convulsions, coma and death
Cardiac glycosides (C01A)Preparations, containing calcium (A12A)Intravenous drugs, containing calcium, patients, receiving cardiac glycosides, dangerous, because it could lead to the development of severe heart rhythm disorders
ScopolamineÈtinamatDangerous impact ètinamata. (Avoid sharing)
Hypnotics and sedatives (N05C)Analeptiki breathing (R07AB, N06BC)Respiratory analeptic poisoning used hypnotics and sedatives.

However, it should be remembered, that in severe poisoning of hypnotics and sedatives application analeptikov undesirable, because in this case, exploding a mismatch between demand and supply of oxygen to the tissues

SpironolakgonAmilorideDangerous potassium delay. The risk of arrhythmia
NimodipineDangerously declining AD
TriamtereneDangerous potassium delay. The risk of arrhythmia
Funds, improve tone and oxytocics activity oxytocics (G02A)The combined use of ergometrine and dopamine; oxytocin and ergot alkaloids is dangerous
Strophanthin KAnxiolytics (N05B)Perhaps the dangerous retardation
Hypnotics and sedatives (N05C)Perhaps the dangerous retardation
SufentanilNaltrexonePossible stops breathing, coma and death
TerazosinNimodipineDangerous decline ad
TilidineNaltrexonePossible stops breathing, coma and death
Thiopental sodiumSulfonamides (J01EB, J01EC, J01ED)Danger stop breathing
TriamtereneAmilorideDangerous rise in the level of potassium in the blood
Antidepressants (N06A)A dangerous fall in HELL. (Without supervision to avoid sharing)
Digitalis glycosides (C01AA)Decreases toxicity glycosides naperstanki. (You need control over the level of potassium in the blood)
Corticosteroids for system application H02 (H02)Severe potassium loss causes dangerous heart rhythm disorders
NikardeepinA dangerous drop in blood pressure. (Needed correction doses)
NimodipineA dangerous fall in HELL
Organic nitrates (C01DA)The strong fall in HELL
SpironolakgonDangerous rise in the level of potassium in the blood
TriamcinoloneDigitalis glycosides (C01AA)Dangerous reduction in the level of potassium in the blood plasma
TrimipraminePreparations, CNS depressants (N05)Raises the perilous block
Hypnotics and sedatives (N05C)Raises the perilous block
PhenobarbitalAnalgesics, opioid (N02a)A dangerous block. (Avoid simultaneous application)
Psychotropic drugs (N05, N06)A dangerous block. (Avoid simultaneous application)
Phenothiazine derivatives (N05AA, N05AB, N05AC)Α-adrenoceptor blockers (C02CA)Intensifies the action of α-adrenoceptor Blocker. Can develop bradycardia, gipotenziya, fatigue, drowsiness, heart rhythm disturbances, patients receptacles limbs, frequent attacks of bronchial asthma and t. d. Amplified a dampening effect on the central nervous system derivatives fenotiazina
Β blockers- adrenoreceptorov (C07)Bradycardia, gipotenziya, fatigue, drowsiness, Cardiac arrhythmia, patients receptacles limbs, frequent attacks of bronchial asthma, etc.
FlavoksatÈtinamatDangerous impact ètinamata. (Avoid sharing)
FlunitrazepamPsychotropic drugs (N05, N06)Development status of anxiety of excitation, ajitation and socially dangerous behaviour with subsequent amnesia
FluoxetineAntithrombotics (B01a)Confusion, excitation, convulsions, the rise of HELL due to increased plasma concentrations of fluoxetine
Digitalis glycosides (C01AA)Confusion, excitation, convulsions, upgrade HELL
MAO inhibitors (N06AF, N06AG, C02KC)Confusion, excitation, convulsions, upgrade HELL. (The combination is contraindicated)
FotemûstinDakarʙazinThere have been cases of toxic effects on the part of the respiratory system (respiratory distress syndrome, adult)
Quinidineb- adrenomimetiki (G02CA, R03AB, R03AC, R03CB, R03CC)There is a risk of development of gross violations heart rhythm
Anticholinesterases (N07AA, A03F, S01EB)The development of atrial fibrillation the ventricles of the heart
QuinonesRisk of poisoning increases hinidine against the backdrop of quinine
Chloral hydrateÈtinamatDangerous impact ètinamata. (Avoid sharing)
XlortalidonGlucocorticoids (H02AB)Severe potassium loss lead to dangerous arrhythmia
Corticosteroids for system application H02 (H02)Severe potassium loss lead to dangerous arrhythmia
Neselekgivnye inhibitors of reverse takeover neironalnogo monoaminov (N06AA)A dangerous drop in blood pressure. (Avoid sharing without supervision)
CisaprideSubstances, metaboliziruûŝiesâ with the help of the enzyme zitohroma P450Increased concentrations of cisapride in plasma, and increases the risk of fatal arrhythmias
ItraconazoleIncreased concentrations of cisapride in plasma, and increases the risk of fatal arrhythmias
KetoconazoleIncreased concentrations of cisapride in plasma, and increases the risk of fatal arrhythmias
ClarithromycinIncreased concentrations of cisapride in plasma, and increases the risk of fatal arrhythmias
MikonazolIncreased concentrations of cisapride in plasma, and increases the risk of fatal arrhythmias
FluconazoleIncreased concentrations of cisapride in plasma, and increases the risk of development of fatal arrhythmias
ErythromycinIncreased concentrations of cisapride and blood plasma, and increases the risk of fatal arrhythmias
Circular

amines (J05ac)

Anoreksigennye drugs (A08AA)There may be excessive stimulation and initiation of CNS. Rising anti-virus effect
CyclobarbitalAnalgesics, opioid (N02a)There might be a dangerous block
Psychotropic drugs (N05, N06)

 

A dangerous block. (Avoid simultaneous application)
CyclosporineAminoglikozidy (J01G)Increases nefrotoksicnosti. (Dangerous combination, You must avoid)
Амфотерицин BIncreases nefrotoksicnosti. (Dangerous combination, You must avoid)
Calcium antagonists (C08)Increases plasma concentration. (Dangerous combination, If possible, it is necessary to avoid; need monitoring plasma concentration, dose adjustment)
Hormonal contraceptives (G03A)Increases plasma concentration of Cyclosporine. (Dangerous combination, If possible, it is necessary to avoid; need monitoring plasma concentration, dose adjustment)
HMG-CoA reductase inhibitors (C10AA)Myo, muscular weakness. (Dangerous combination, You must avoid)
KetoconazoleSlows inachtiwatia Cyclosporine, that leads to an increase in its concentration in the blood plasma and the frequency of side effects. (Dangerous combination. There is a need to avoid sharing)
ColchicineIncreases nefrotoksicnosti. Myo, muscular weakness. (Dangerous combination; You must avoid)
LovastatinDangerous combination, giving rise to acute renal failure. (There is a need to avoid sharing)
Makrolidы (J01FA)Increases plasma concentration (Dangerous combination, If possible, it is necessary to avoid; need monitoring plasma concentration, dose adjustment)
MelfalaneIncreases nefrotoksicnosti. (Dangerous combination, You must avoid)
NSAIDs (M01A, M01V)Increases nefrotoksicnosti. (Dangerous combination, You must avoid)
PrednisoloneIncreases plasma concentration of Cyclosporine, and reduced clearance of prednisone. (Dangerous combination, If possible, it is necessary to avoid; need monitoring plasma concentration, dose adjustment)
PropafenoneIncreases plasma concentration. (Dangerous combination, If possible, it is necessary to avoid; need monitoring plasma concentration, dose adjustment)
TrimethoprimIncreases nefrotoksicnosti. (Dangerous combination, You must avoid)
CiprofloxacinIncreases nefrotoksicnosti. (Dangerous combination, You must avoid)
ErythromycinIncreases the concentration of Cyclosporine in the blood plasma. (Dangerous combination. There is a need to avoid sharing or make a correction dose)
CimetidineMorphineRespiratory depression
FentanylRespiratory depression
EnalaprilDigitalis glycosides (C01AA)You need control over the level of potassium in the blood
EpinephrineNorepinephrineHeart rhythm disturbances, hypertension and even death
ErgotaminAnalgesics (N02)A dangerous block. (Avoid simultaneous reception)
Antihistamines (R06, D04, A07EB, B01AC, R03BC, S016)A dangerous block. (Avoid sharing)
Fenilzgilamina derivatives (N06BA)Dangerous upgrade HELL
PseudoephedrineDangerous upgrade HELL
Psychotropic drugs (N05, N06)A dangerous block. (Avoid simultaneous reception)
EpinephrineDangerous upgrade HELL
EphedrineDangerous upgrade HELL

Back to top button