Oleandomiцin

When ATH:
J01FA05

Characteristic.

Macrolide antibiotics, produced radiant fungus Streptomyces antibioticus or other related pathogens. Crystalline powder or porous mass of white or white with a yellowish tint, bitter taste. Easily soluble in water, soluble in dilute acids, is highly soluble in ethanol, hygroscopic.

Pharmacological action.
Antibacterial, bacteriostatic.

Application.

Pneumonia, pleurisy, lung abscess, empyema, ʙronxoektazii, tonsillitis, otitis, scarlet fever, Diphtheria, pertussis, trachoma, protracted endocarditis, meningitis, sepsis (staphylococcal, streptococcal, pneumococcal), osteomyelitis, furunculosis, gonorrhea, enterocolitis, urinary and biliary tract (if not amazed liver parenchyma) and other diseases, caused by microorganisms, sensitive to oleandomycin, incl. when resistance to other antibiotics (especially penicillins).

Contraindications.

Hypersensitivity, parenchymal liver.

Pregnancy and breast-feeding.

During pregnancy and breast-feeding is prescribed with caution.

Side effects.

Allergic reactions (itching, hives, angioedema), nausea, vomiting, diarrhea.

Cooperation.

Acceptable combination with tetracyclines, chloramphenicol, Nystatin, sulьfanilamidami.

Dosing and Administration.

Inside, после еды по 0,25–0,5 г 4–6 раз в сутки. Higher doses for adults: single - 0,5 g, daily - 2 g. Higher daily doses for children: to 3 years - 0,02 g / kg, from 3 to 6 лет — 0,25–0,5 г, from 6 to 14 лет — 0,5–1 г, senior 14 лет — 1–1,5 г. The course of treatment - 5-7 days.

Precautions.

To prevent the development of microbial resistance recommended combination with other antimicrobial agents, especially tetracycline.

It should be taken into account, what 1 мг препарата содержит не менее 750 ED. 1 ЕД соответствует по активности 1 мкг олеандомицина основания.

Cautions.

A macrolide is obsolete and is not widely applied at the present time.