Nurofen for Children (Suppozitorii)

Active material: Ibuprofen
When ATH: M01AE01
CCF: NSAIDs
ICD-10 codes (testimony): G43, H92.0, J06.9, J10, K08.8, M79.2, R07, R50, R51, R52.0, T14.3
When CSF: 05.01.01.06
Manufacturer: RECKITT BENCKISER HEALTHCARE INTERNATIONAL Ltd. (Great Britain)

Pharmaceutical form, composition and packaging

◊ Rectal Suppositories (for children) white or nearly white, Valium, smooth.

Excipients: tallow 1 (uitepsols H15), tallow 2 (vitepsol W45).

5 PC. – aluminum blisters (2) – packs cardboard.

Pharmacological action

NSAIDs. It has analgesic, anti-inflammatory and antipyretic effect. The mechanism of action of ibuprofen due to inhibition of the biosynthesis of prostaglandins - mediators of pain and inflammation. Effect of the drug continues to 8 no.

Pharmacokinetics

Data for farmakokinetike Nurofen^® Children are not provided.

Testimony

For children c 3 months of life to 2 years:

- as an antipyretic agent for acute respiratory diseases, Flu, childhood infections, postprivivochnyh reactions and other infectious and inflammatory diseases, accompanied by fever;

- as an analgesic agent for pain syndrome weak or moderate intensity, including: headache, toothache, migraine, neuralgia, pain in the ears and throat, the pain of sprains.

Dosage regimen

Nurofen^® suppositories for children are specially designed for children. The drug is used rectally.

At fever and pain dose depends on the age and weight of the baby's body. A single dose of 5-10 mg / kg 3-4 times / day. The maximum daily dose – 30 mg / kg.

For children 3-9 Months (weight 5.5-8 kg) appoint 1 supp. (60 mg) 3 times / day at intervals 6-8 no, but not more 180 mg / day.

Children ages 9 Months before 2 years (weight 8-12.5 kg) appoint 1 supp. (60 mg) 4 times / day at intervals 6 no, no more 240 mg / day.

At Post-immunization fever children under the age of 1 year appointed 1 supp. (60 mg); older children 1 year also – 1 supp. (60 mg), if necessary through 6 h you can still 1 supp. (60 mg).

Duration of treatment: no more 3 days as antipyretic, no more 5 days as an analgesic. If fever persists, it is necessary to consult a doctor.

Do not exceed the specified dose.

Side effect

From the digestive system: rarely – nausea, vomiting, discomfort, or epigastric pain, laxative effect, possible occurrence of erosive and ulcerative lesions, bleeding.

Allergic reactions: rarely – skin rash, itch, hives, exacerbation of asthma, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm, fever, erythema multiforme exudative (incl. Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).

From the nervous system: rarely – headache, dizziness, psychomotor agitation, insomnia.

Cardio-vascular system: rarely – tachycardia, increased blood pressure.

On the part of the hematopoietic system: rarely – anemia, thrombocytopenia, agranulocytosis, leukopenia.

From the urinary system: rarely – impairment of renal function, cystitis.

Contraindications

- Bronchial asthma, hives, rhinitis, provoked by taking acetylsalicylic acid (salicylates) or other NSAIDs;

- Ulcerative lesions GIT;

- Active gastrointestinal bleeding;

- Inflammatory Bowel Disease;

- Confirmation of hypokalemia;

- Blood disorders: hypocoagulation, leukopenia, hemophilia;

- kidney and / or liver failure;

- Hearing loss;

- Hypersensitivity to the drug;

- Hypersensitivity to aspirin or other NSAIDs.

Cautions

Possibility of application of the drug Nurofen^® children's doctor decides individually in the following cases:

- if the child is receiving other analgesics;

- if there is indication of a history of peptic ulcer disease, gastritis, yazvennыy colitis, bleeding from the gastrointestinal tract;

- for liver or kidney;

- the detection of Helicobacter pylori;

- on therapy with indirect anticoagulants, drugs to lower blood pressure, GCS, antiplatelet, Diuretics, lithium preparations, metotreksatom;

- in children with asthma, krapivnicej.

When side effects should stop using the product and seek medical advice.

Overdose

Symptoms: rarely – stomach ache, nausea, vomiting, headache, noise in ears, metabolic acidosis, coma, acute renal failure, decrease in blood pressure, bradycardia, tachycardia.

Treatment: diurez, simptomaticheskaya therapy. In case of accidental excess of the recommended dose needed immediate medical consultation.

Drug Interactions

Simultaneous application Nurofena^® for children with anticoagulants can lead to an increase of their actions.

Nurofen^® children increases the concentration of digoxin, phenytoin, methotrexate, lithium in the blood plasma while the use of these drugs.

The use of Nurofen^® for children with diuretics and antihypertensive drugs reduces their effectiveness.

Nurofen^® children increases the side effects of corticosteroids and mineralocorticoids.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children, dry place at temperatures no higher than 25 ° C. Shelf life – 2 year.