Nitroksolin (When ATH J01XX07)

When ATH:
J01XX07

Characteristic.

The 8-hydroxyquinoline.

Crystalline powder yellow-green color with dusky hue, without smell, bitter taste. At 80 °C sublimes. Practically insoluble in water, very slightly soluble in ether, slightly soluble in chloroform and ethanol, difficult - in acetone, easily soluble in hot alkalis and acids.

Pharmacological action.
Antibacterial.

Application.

Infectious-inflammatory diseases of the urinary tract, caused by susceptible microorganisms (incl. pyelonephritis, cystitis, uretrit), epididymitis; infected adenoma or carcinoma of prostate, etc..); prevention of infectious complications in diagnostic and therapeutic interventions (catheterisation, cystoscopy, after operations on the kidneys and urinary tract).

Contraindications.

Hypersensitivity (incl. other derivatives of 8-hydroxyquinoline), renal dysfunction, accompanied by oliguria, anwrïey; severe liver disease, Cataract, neuritis, polyneuritis, deficiency of glucose-6-fosfatdegidrogenazы, pregnancy, lactation.

Side effects.

Dyspepsia (nausea, vomiting), loss of appetite, allergic reactions (skin rash); tachycardia, ataxia, headache, paresthesia, polyneuropathy, abnormal liver function. With prolonged use, the case of neuritis of the optic nerve.

Dosing and Administration.

Inside, while eating, adults - 100 mg 4 once a day, The maximum daily dose - 800 mg. The average dose for children under 5 years - 50 mg, 5 and older - 50-100 mg 4 once a day. The course of treatment - 2-3 weeks. Repeated courses (in case of need) carried out with a 2-week break. In chronic recurrent processes of treatment amounts to a few months.

To prevent infections during operations on the kidneys and urinary tract - for 100 mg 4 times a day for 2-3 weeks.

Precautions.

With caution is prescribed for kidney failure (cumulative effect is possible).

Cautions.

During treatment, the urine is painted in saffron-yellow color.