Nitrofurantoin (When ATH J01XE01)

When ATH:
J01XE01

Characteristic.

Yellow or orange-yellow crystalline powder, bitter taste. Practically insoluble in water and alcohol.

Pharmacological action.
Antibacterial broad-spectrum, bactericide.

Application.

Pyelitis, pyelonephritis, cystitis, uretrit; prevention of infections in urologic surgery, cystoscopy, Catheterization.

Contraindications.

Hypersensitivity, violation of kidney function, liver, deficiency of glucose-6-fosfatdegidrogenazы, acute porphyria, pregnancy, Early infancy (to 1 Months).

Restrictions apply.

Lactation (at the time of treatment should stop breastfeeding).

Side effects.

Interstitial lung abnormalities, bronchial obstruction, fever, cough, chest pain, gepatitы, cholestatic syndrome, peripheral neuropathy, asthenia, dizziness, nistagmo, headache, drowsiness, nausea, vomiting, rare - abdominal pain, diarrhea, pancreatitis, psevdomembranoznыy colitis, allergic reactions: lupus-like syndrome, artralgii, mialgii, anaphylaxis, chills, eozinofilija, rash.

Cooperation.

Antibacterial effect reduces nalidixic acid, Suction - antacidy, containing magnesium trisilicate. Incompatible with fluoroquinolones. Funds, promote the excretion of uric acid (probenecid, sulfinpirazon) can inhibit secretion by the renal tubules, This reduces the level of nitrofurantoin in the urine (reduced antibacterial effect) and increased blood (increased toxicity).

Overdose.

It appears vomiting. Receive a large amount of liquid leads to increased urinary excretion of the drug. Effyektivyen dialysis.

Dosing and Administration.

Inside, while eating, adults - 100-150 mg 3-4 times a day; Course of treatment - 5-8 days. Higher doses for adults inside: single - 300 mg, daily - 600 mg. Doses for children - the rate of 5-8 mg / kg per day (3-4 reception).