Nimesil: instructions for using the medicine, structure, Contraindications

Title: Nimesil (Nimesil)

Manufacturer: GUIDOTTI S.p.A./Menarini Laboratories (Italy).

Nimesil: structure

The main active substance of nimesil is nimesulide. There are also excipients: lemon acid, orange flavor, ketomacrogol 1000 and maltodextrin.

Nimesil: pharmachologic effect

Nimesil provides a pronounced analgesic, antipyretic and anti-inflammatory effect. The principle of functioning of this drug lies in the inhibition of the synthesis of prostaglandins. Nimesil inhibits the synthesis of prostaglandins at the site of inflammation more effectively, than in the gastric mucosa or in the kidneys. With long-term treatment, the drug is quite well tolerated.. Its action develops relatively quickly, what do the properties of the dosage form contribute to. The duration of the effect is on average 6 hours.

Nimesil: Indications for use

Nimesil is prescribed for:

• pain syndromes of various origins (head, dental, menstrual pain, consequences of injuries, postoperative pain, pain from rheumatism, etc.);
• infectious and inflammatory diseases (traumatic and postoperative inflammation)
• degenerative and inflammatory diseases of the musculoskeletal system (artritax, osteoarthritis, osteochondrosis, bursa, radicals, rheumatism, etc.);
• urological, gynecological and vascular diseases;
• Diseases, accompanied by fever.

This tool is appropriate as in long-term therapeutic therapy., and for dulling severe pain syndromes.

Nimesil: mode of application

Nimesil is prescribed exclusively for adults. The drug is taken orally, postprandial. The average daily allowance is 200 mg: two receptions on 100 mg. To prepare the suspension, the contents of the sachet are poured into a glass and poured with warm water.. Dose can be increased as needed. This is necessary for especially severe symptoms.. The dose may also be adjusted according to the patient's response.. Elderly people need to adjust the dose of the drug.

Nimesil: side effects

The drug is usually well tolerated with long-term use., but at the beginning of the course, as well as at high doses, various side effects are not excluded.

Disorders can be from the following systems:

• Central nervous system. It's a headache, dizziness, encephalopathy, drowsiness, nervousness, a sense of fear, nightmares. If you sharply reduce the dose of the drug and further increase it more smoothly and carefully, then these disorders will pass.
• Cardiovascular system. It's hypertension, tachycardia, gemorragija, tides. These events are quite rare..
• Organs of the gastrointestinal tract. Nausea, vomiting and diarrhea are rare. Dispersion, ulcer, tarry stools, gastrointestinal bleeding and gastric perforation - very rare. Sometimes there may be flatulence, constipation or gastritis.
• Senses. Very rarely visual impairment.
• Respiratory. Bronchospasm and shortness of breath may also occur quite rarely..
• Skin covering. Sometimes hyperemic reactions are possible, such as rashes, itching and redness, possible excessive sweating. Rarely, dermatitis may occur., эritema, and very rarely - various edema.
• Biliary system and liver. Possible elevation of liver enzymes, rarely jaundice, hepatitis and cholestasis.
• Urinary system and kidneys. Dizurija, urinary retention and hematuria are rare, and oliguria, renal failure and interstitial nephritis - very rare.
• Hematopoietic system. Rarely eosinophilia and anemia. Phenomena such as pancytopenia, and thrombocytopenia Purpura, very rare.

Nimesil: Contraindications

The drug should not be used with:

• stomach or duodenal ulcer;
• heavy bleeding from the gastrointestinal tract;
• pregnancy and lactation;
• overt and severe kidney dysfunction;
• hypersensitivity to any component of this agent;
• izžoge, toshnote, diarrhea, rvote, stomach ache;
• type 2 diabetes;
• Congestive heart failure;
• hypertension.

Nimesil is contraindicated for use by children.

Nimesil: pregnancy

The use of this drug is incompatible with pregnancy. If you need to take Nimesil, breastfeeding should be stopped..

Nimesil: drug interaction

The drug enhances the effect of drugs, which are used to reduce blood clotting. Nimesil can also increase the effect of furosemide. With the simultaneous administration of Nimesil and methotrexate, side effects may worsen. Nimesulide rapidly binds to plasma proteins, so faces, who are treated with sulfonamides and hydantoin, should be under close medical supervision. The drug enhances the effect of cyclosporine on the kidneys. If Nimesil is used simultaneously with lithium preparations, then the plasma concentration of lithium will increase.

Treatment with Nimesil requires caution, if pressure medications are used in combination with it, diuretics or other anti-inflammatory and pain medications.

Nimesil: overdose

With an overdose of the drug, side effects become more pronounced.. Overt symptoms: nausea, apathy, drowsiness, vomiting, less gastrointestinal bleeding. There is no specific antidote for this case.. To eliminate the results of an overdose, gastric lavage and activated charcoal are taken.. If needed, supportive and symptomatic therapy is carried out.

Nimesil: release form

Distribute Nimesil in cardboard packs, containing 30 laminated aluminum foil bags. The sachet contains granules for the preparation of a therapeutic suspension.

Nimesil: storage conditions

Keep the drug in a place protected from light., dry place at room temperature.
Storage life – 2 year.

Nimesil: synonyms

Nimesulide, aponil, mesulid, actasulide, cocktail, nimegesik, friend, nimika, nimulid, flolid, prolid

Nimesil: pharmacological group

• Painkillers and anti-inflammatory drugs
• Nonsteroidal anti-inflammatory drugs
• Active substance: Nimesulide

Nimesil: additional warnings

Caution should be exercised when treating the elderly with this drug.. If vision deteriorates during the treatment cycle, then taking Nimesil should be stopped immediately and contact an ophthalmologist for help. Person, suffering from diabetes, must report, that this medicine contains sucrose. Also, caution in the use of Nimesil is needed for those people, whose activities are associated with a quick reaction and increased attention.