Natamycin (When ATH D01AA02)

When ATH:
D01AA02

Characteristic.

Polyene antibiotics (tetraene polyene group), produced Streptomyces natalensis. The powder is white or cream-colored, insoluble in water. Soluble in glacial acetic acid and dimethylformamide, poorly - in methanol. Sensitive to light. Molecular weight - 665,72.

Pharmacological action.
Broad spectrum antifungal, fungicidnoe.

Application.

Fungal diseases of the skin and mucous membranes, caused by pathogens susceptible to natamycin, including acute pseudomembranous candidiasis and atrophic acute against the background of cachexia and immune deficiency, and after antibiotic therapy, corticosteroids and cytostatics; candidiasis of the skin and nails, intestinal candidiasis; vaginitis, vulvity, vulvovaginitises, balanopostity, caused mainly by fungi Candida; ringworm; otomycosis, otitis externa (incl. primarily caused by fungi or complicated candidiasis); as adjunctive therapy in the treatment of ringworm griseofulvin.

Contraindications.

Hypersensitivity, lupus.

Side effects.

If ingestion - nausea, vomiting, diarrhea; when local use - a slight irritation and a burning sensation at the application site.

Dosing and Administration.

Inside, adults with intestinal candidiasis - By 100 mg 4 twice a day for an average of 1 Sun; children - 100 mg 2 once a day.

When ringworm (incl. skin candidosis, polish) cream applied to the affected surface of the skin one or more times per day, when otomycosis - cream is applied once or several times a day (before applying clean ear, and after the application was placed in the auditory canal turunda cotton or wool).

When vaginitis, vulvytah, vulvovaginitis: intravaginal - By 100 mg (1 supp.) for 3-6 days (suppository inserted into the vagina, while in the prone position, as far as possible, 1 once a day at night). During menstruation, the use of suppositories interrupt. When persistent Amount pr car vaginitov, caused Candida albicans, addition of a tablet (by 100 mg 1-4 times a day for 10-20 days) for sanitation focus of Candida infection in the gut.

When balanoposthitis cream is applied to the affected skin once or several times a day.

The duration of treatment is determined individually. After the disappearance of the symptoms of treatment is recommended to continue for a few days.

Precautions.

For the treatment of genital candidiasis lesions partners use cream. During treatment, there is no need to exclude sex, but it is recommended to conduct a survey of sexual partners and, in the case of Candida defeat, a course of treatment of natamycin. You should also provide for the use in treatment of barrier contraceptives.