Nandrolon

When ATH:
A14AB01

Characteristic.

Anabolicheskiй steroid. Nandrolone phenylpropionate is white or white with kremovatam white crystalline powder with a characteristic odour. Practically insoluble in water, sparingly soluble in ethanol, slightly soluble in chloroform and acetone. Nandrolone decanoate-crystals from white to yellow. Practically insoluble in water, freely soluble in ethanol, ether, acetone, xloroforme, oils.

Pharmacological action.
Androgenic, anabolic, antianemic, antitumor.

Application.

Chronic infections, severe injury, major surgery, steroidnaya myopathy, anemia in chronic renal failure, mielofiʙroze, mieloskleroze, myeloid bone marrow aplasia (refractory to conventional therapy), Bone marrow metastases of malignant neoplasms, myelotoxic drugs and heavy metal salts; inoperable (with metastases) carcinoma of breast cancer in post-menopausal women or after ovariectomy; growth retardation in children, caused by a deficiency of growth hormone.

Contraindications.

Hypersensitivity, carcinoma or prostatic hypertrophy, Malignant tumors of the breast in men, breast carcinoma in women with hypercalcemia (It is able to activate osteoclasts and induce bone resorption), pregnancy (It has embryotoxic, fetotoxic, can cause masculinization of female fetus), CHD, expressed atherosclerosis; heart failure and other conditions, accompanied by edema syndrome, acute and chronic liver disease, incl. alcoholic defeat, jade, nephrotic syndrome, lactation.

Side effects.

In both men and women — the progression of atherosclerosis (increased concentrations of LDL and decrease HDL concentration), zhelezodefitsitnaya anemia, peripheral edema, dyspeptic disorders (abdominal pain and epigastric, nausea, vomiting), abnormal liver function with jaundice, leykozopodobny syndrome (changes in leukocyte formula, pain in the long bones), hypocoagulation with a tendency to bleeding, gepatonekroz (dark stools, vomiting with blood, headache, discomfort, respiratory failure), gepatocellûlârnaâ cancer, pechenochnaya purpura (dark urine, discoloration of the stool, hives, makuleznye point or hemorrhagic rash on the skin and mucous membranes, pharyngitis or tonsillitis), cholestatic hepatitis (yellow coloration of the skin and sclera, pain in the right upper quadrant, dark-colored urine, discolored stools). Women — virilism (enlargement of the clitoris, brutalization vote, Thesis- and amenorrhea, hair growth on male type), hypercalcemia (CNS depression, nausea, vomiting, fatiguability). Men: in prepubertal period — virilism (acne, Penis Enlargement, priapism, formation of secondary sexual characteristics), idiopathic hyperpigmentation, slowing or stopping the growth of (calcification of epiphyseal growth zones of long bones); in postpubertatne period is irritation of the bladder (increased frequency of urinary urgency), seal breast, gynecomastia, priapism, in old age-hypertrophy and/or Carcinoma of the prostate.

Cooperation.

Glucocorticoids, mineralokortikoidы, kortykotropyn, sodium-containing medicines and food, rich in sodium, potentiate (mutually) fluid retention, increase the risk of edema, increase the severity of acne. It enhances the effects of antiplatelet agents, anticoagulants, insulin and oral antidiabetic agents (inhibits their biotransformation), weakens-DOLLAR and its derivatives (It accelerates the mineralization of the epiphyseal growth zones of long bones). Reduces liver toxicity of other drugs.

Dosing and Administration.

/ M, deep. Nandrolone decanoate: with anemia (simultaneously with iron preparations) is 100-200 mg (women 50-100 mg) 1 once a week; to stimulate anabolic processes 50-200 mg (women 50-100 mg) 1 every 1-4 weeks; children 2-13 years — 25-50 mg 1 every 3-4 weeks. Duration of the course (at 1-4 week intervals between injections) - To 12 Sun, Refresh course — via 8 weeks after the last injection. Treatment is carried out against the background of a high-protein diet. Breast carcinoma (nandrolone phenylpropionate) is 50-100 mg 1 once a week; duration of the course is individual.