Nalʙufin

When ATH:
N02AF02

Pharmacological action.
Analgesic (opioid).

Application.

Pain syndrome secondary to severe intensity in myocardial infarction, in preparation for surgery (prevention) and in the postoperative period; as an aid to anesthesia during general anesthesia.

Contraindications.

Hypersensitivity.

Restrictions apply.

Violation of the liver and kidneys, increased intracranial pressure, respiratory depression (incl. uremia, exacerbation of asthma, severe infections), surgery for hepatobiliary system (vozmoƶen spazm simple sfinktera), pregnancy, delivery, Children and Youth age (to 18 years).

Side effects.

From the nervous system and sensory organs: drowsiness, Respiratory depression center (small doses slows and increases the depth of the respiratory movements), headache, euphoria or depression, disforija, hallucinations.

Cardio-vascular system and blood (hematopoiesis, hemostasis): Hypertension / hypotension, bradycardia / tachycardia, pulmonary edema.

From the digestive tract: dry mouth, nausea, vomiting, dyspepsia, cramping.

Allergic reactions: anaphylactic or anaphylactoid shock, bronchospasm, hives, laryngeal edema, itch, chikhaniye.

Other: desudation, pain at the site of the / m injection.

Cooperation.

General anesthetics, trankvilizatorы, sedatives and hypnotics, enhance the effects of alcohol, incl. side (combination therapy is necessary to lower the dose of nalbuphine and / or these drugs).

Overdose.

Symptoms: increased side effects, loss of consciousness, coma, periodic breathing such as Cheyne - Stokes, pallor, and lowering the temperature of the skin, declination of fever, mioz; death (paralysis of the respiratory center).

Treatment: gastric lavage, in / in a specific antidotes - nalorphine or naloxone, or oxygen therapy, maintaining vital functions.

Dosing and Administration.

B /, / m. Adults: w / w or w / o of 0.15-0.3 mg / kg body weight. If necessary - re every 3-6 hours. The maximum single dose - 0,3 mg / kg, maximum daily - 2,4 mg / kg.

Babies: in / in or / m at 0.1-0.25 mg / kg. The maximum single dose 0,25 mg / kg, maximum daily - 2 mg / kg.

When general anesthesia: initially introduced into / drip 0.3-3.0 mg / kg within 10-15 min, then - a maintenance dose of 0,25-0,5 mg / kg single dose.

Precautions.

Not recommended more 3 days and exceed the dosage, tk. possible physical dependence. Sudden discontinuation after prolonged use can cause withdrawal symptoms (abdominal cramping, nausea, vomiting, rhinorrhea, lacrimation, weakness, anxiety, fever). Be wary appoint emotional instability, Addiction (a high probability of an acute attack of withdrawal). Due to the sedative and hypnotic effects should not be used on an outpatient basis drivers of vehicles and people, professions that require rapid mental and motor responses.

Cautions.

In a formulation as a preservative contained sodium disulfite, which can cause patients with bronchial asthma (if you are sensitive to sulfites) asthma, anaphylactic or anaphylactoid shock.