Naftidrofuril

When ATH:
C04AX21

Pharmacological action.
Vasodilator, improves peripheral circulation.

Application.

Poor circulation in obliterating peripheral vascular disease lower limb (syndrome, intermittent claudication, Raynaud's disease), trophic disorders (bedsores, nonhealing ulcers, diabetic angiopathy), quiet hip disease (initial stage), cerebrovascular accidents, cerebral insufficiency with mental disorders and hearing loss in the elderly (except senile dementia and Alzheimer's disease), idiopathic hearing loss, Meniere's disease, traumatic encephalopathy, retinal artery disease.

Contraindications.

Hypersensitivity, acute myocardial infarction, acute hemorrhagic stroke, severe heart failure, arrhythmia, increased bleeding, epilepsy, pregnancy, lactation, childhood.

Side effects.

Weakness, headache, sleep disorders, excitation, decrease in blood pressure, orthostatic dizziness and collapse, tachycardia, nausea, epigastric pain, esophagitis, diarrhea, changes in the level of liver enzymes, allergic skin reactions.

Cooperation.

It increases the severity of negative cardiotropic effects of beta-blockers, etc.. anti-arrhythmic drugs. Solution for injection pharmaceutically incompatible with calcium ions.

Overdose.

Symptoms: confusion, convulsions.

Treatment: gastric lavage, administration of activated charcoal, monitoring and maintenance of vital functions.

Dosing and Administration.

/ M, I /. Violations of peripheral blood circulation — at a daily dose of 40-160 mg. In severe limb ischemia, načinaûŝejsâ gangrene, as well as with cerebrovascular disorders — in/in slowly (for 1.5-2 hours) 200 mg (preliminary dissolve in 250-500 ml of physiological solution, or 5% glucose solution); the course duration is 7-10 days.

Precautions.

Caution should be used when the propensity to vascular collapse, orthostatic dizziness, increased convulsive readiness. Absence of clinical improvement in elderly patients require discontinuation of treatment. During the reception, it is recommended to refrain from smoking and drinking. Should not be used during the drivers of vehicles and people, skills relate to the high concentration of attention.