METROGEKS

Combined antimicrobial.

Metronidazol – nitroimidazole derivative, possesses antiprotozoal and antibacterial action against anaerobic protozoa and anaerobic bacteria, causing periodontitis: Porphyromonas gingivalis, Prevotella intermedia, Prevotella denticola, Fusobacterium fusiform, Wolinella straight, Treponema spp., Eikenella corrodens, Borrelia winning, Bacteroides melaninogenicus, Selenomonas spp. Activity against aerobic bacteria.

The mechanism of action consists in biochemical restoration of 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole interacts with cells of microorganism DNA, inhibiting the synthesis of nucleic acids, that leads to the death of the bacteria.

Chlorhexidine - Disinfectant, active against a broad spectrum of gram-negative vegetative forms of micro-organisms and Gram-positive, yeast, dermatophytes and lipophilic viruses. At the bacteria spores acts only at elevated temperature. The bactericidal effect is caused by the binding of cations (It results in dissociation of the salt of chlorhexidine physiological medium) with the negatively charged bacterial cell walls and complexes ekstramikrobnyh. At low concentrations, disrupting the osmotic balance of the bacterial cells and leaving the potassium ions and phosphorus, It has a bacteriostatic effect; at high concentrations of cytoplasmic contents of a bacterial cell deposited, which leads eventually to the death of the bacteria.