Methyl salicylate

When ATH:
It refers to a group M01A, M02A, N02BA

Pharmacological action.

Methyl salicylate is a salicylic acid derivative and has a local irritant. Irritation skin receptors, methyl salicylate, leads to the formation and ejection of blood into a large number of biologically active substances, that regulate pain sensitivity. There is a release of substance P from neuronal. Reducing the accumulation of substance P in the nerve endings resulting in pain reduction. Besides, methyl salicylate, which belongs to the group of non-steroidal anti-inflammatory agents, inhibits the synthesis of prostaglandins due to inhibition of cyclooxygenase, that reduces swelling and infiltration of the inflamed tissue.

Anti-inflammatory pain reliever. Non-selectively inhibit cyclooxygenase, reducing the synthesis of prostaglandins. It normalizes the increased capillary permeability, improves microcirculation, reduces swelling and infiltration of inflammatory tissue. It has only local effect.

Dosing and Administration

Locally, applied to the area of ​​the affected joints and grind.

Contraindications

Hypersensitivity (incl. to others. salicylic acid derivatives).

Restrictions apply

Pregnancy, childhood.

Side effects

Irritation at the site of application, allergic skin reactions.

Cooperation

Anti effect, methotrexate.

Overdose

Available in children and, when applied to extensive skin.

Symptoms: headache, tinnitus, visual disturbances, nausea, vomiting, diarrhea, epigastric pain, respiratory alkalosis or metabolic acidosis, hyperthermia, kaliopenia, giperglikemiâ.

Treatment: correction of electrolyte and water balance, appointment of absorbent and laxatives, diurez, external cooling body; in severe cases - a blood transfusion, hemodialysis.

Precautions

It should not be applied to the eroded surface. To prevent acute intoxication salicylates should avoid large amounts of rubbing (especially children and pregnant women).