Active material: Metadoksin
When ATH: N07bb
CCF: Gepatoprotektor. Preparation, alcohol dependence
ICD-10 codes (testimony): F10.2, F10.3, K70, K71, T51
When CSF: 02.18.04
Manufacturer: Laboratoire baldacci save.a. (Italy)
Pills white or nearly white, round, lenticular, with risk on one side and with engraving the name of the drug on the other side.
| 1 tab. | |
| Pyridoxine L-2 pyrrolidone 5-carboxylate (Methodokine) | 500 mg |
Excipients: microcrystalline cellulose, magnesium stearate.
10 PC. – блистеры (1) – пачки картонные.
10 PC. – блистеры (3) – пачки картонные.
Solution for injection clear, colorless or with a weak yellowish tint.
| 1 ml | 1 amp. | |
| Pyridoxine L-2 pyrrolidone 5-carboxylate (Methodokine) | 60 mg | 300 mg |
Excipients: sodium metabisulfite, sodium edetate, Methyl-parahydroxybenzoate, water d / and.
5 мл – ампулы темного стекла (5) – поддоны пластиковые (2) – пачки картонные.
5 мл – ампулы темного стекла (10) – поддоны пластиковые (1) – пачки картонные.
Drug for the treatment of alcoholism, Hepatoprotector. The hepatoprotective effect of the drug is due to a membrane -stabilizing effect and is based on the ability to restore the ratio of saturated and unsaturated free fatty acids. As a result, the stability of hepatocytes increases to the action of lipid peroxidation, which occurs when exposed to toxic ethanol products. The detoxification effect of metadoxin is due to the activation of liver enzymes, participating in the metabolism of ethanol (alcoholdeidrogendrogendrogen), what accelerates the process of elimination of ethanol and acetaldehyde from the body, and hence, their toxic effects are reduced.
Metadoxin prevents the accumulation of triglycerides in hepatocytes, prevents the formation of fibronctin and collagen, which significantly slows down the process of formation of cirrhosis of the liver.
The drug reduces the mental and somatic manifestations of a hangover syndrome, Reduces the time for removing withdrawal syndrome.
Metadoxin activates a cholinergic and Gaba-ergic neurotransmitter systems, improves the functions of thinking and short memory, prevents the occurrence of motor excitement, which is caused by ethanol.
Metadoxin has a non -specific antidepressant and anxiolytic effect, reduces alcohol attraction.
Absorption and distribution
After oral administration, the drug is quickly absorbed from the digestive tract and has high bioavailability (60-80%). Plasma protein binding - 50%.
Metabolism and excretion
Метаболизируется в печени до активных метаболитов – пиридина и пирролидона карбоксилата. T1/2 when taking oral or parenteral administration is 40-60 m. 45-50% the drug is excreted in the urine within 24 no, 35-50% excreted in the feces within 96 no.
- toxic damage to the liver of alcoholic etiology;
- Prevention of the formation of cirrhosis of alcoholic origin;
— acute alcohol intoxication;
- Alcoholism;
- Alcohol withdrawal syndrome;
- decrease in alcohol attraction.
At acute alcohol intoxication Depending on the degree of intoxication, in/m is introduced 300-600 mg (5-10 ml) or / 300-900 mg (5-15 ml).
With V/in administration, the necessary dose of the drug is diluted in 500 ml of isotonic sodium chloride solution or 5% dextrose (Glucose) and introduce drip during 1.5 no.
Toxic damage to the liver of alcoholic etiology, Prevention of the formation of cirrhosis of alcoholic origin and chronic alcoholism: inwards 500 mg (1 tab.) 2 times / day (1 g / day) for 15-30 minutes before meals. The dose can be increased to 500 mg 3 times / day (1.5 g / day) or enter in/m in the dose 300 mg (5 ml)/d. Курс лечения – не менее 90 days.
At alcoholic withdrawal syndrome iv in the form of infusion in a dose 900 mg (15 ml) 1 times / day for 3-7 days depending on the patient's condition.
Maybe: allergic reactions. In patients with bronchial asthma, the development of bronchospasm is possible (When using a solution for injection).
- Pregnancy;
- Lactation (breast-feeding);
- Hypersensitivity to the drug.
The use of the drug Metakoril during pregnancy and during lactation (breast-feeding) contraindicated.
FROM caution The drug should be prescribed for Parkinson's disease, If levodop is used at the same time, tk. metadoxin reduces the effectiveness of the last.
The injection solution contains sodium metabisulfite. This substance can cause in patients, predisposed to asthmatic attacks (especially with bronchial asthma), Allergic reactions or strengthening of asthma attacks.
Currently, cases of an overdose of the drug Metacorine have not been reported.
With the simultaneous use of metacoline, reduces the effectiveness of levodopa.
The drug is released under the prescription.
List B. The drug should be stored out of reach of children, dark place at a temperature no higher than 25 ° C. Shelf life - 5 years.
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