METADOKSIL

Active material: Metadoksin
When ATH: N07bb
CCF: Gepatoprotektor. Preparation, alcohol dependence
ICD-10 codes (testimony): F10.2, F10.3, K70, K71, T51
When CSF: 02.18.04
Manufacturer: Laboratoire baldacci save.a. (Italy)

Pharmaceutical form, composition and packaging

Pills white or nearly white, round, lenticular, with risk on one side and with engraving the name of the drug on the other side.

Excipients: microcrystalline cellulose, magnesium stearate.

10 PC. – blisters (1) – packs cardboard.
10 PC. – blisters (3) – packs cardboard.

Solution for injection clear, colorless or with a weak yellowish tint.

Excipients: sodium metabisulfite, sodium edetate, Methyl-parahydroxybenzoate, water d / and.

5 ml – vials of dark glass (5) – trays, plastic (2) – packs cardboard.
5 ml – vials of dark glass (10) – trays, plastic (1) – packs cardboard.

Pharmacological action

Drug for the treatment of alcoholism, Hepatoprotector. The hepatoprotective effect of the drug is due to a membrane -stabilizing effect and is based on the ability to restore the ratio of saturated and unsaturated free fatty acids. As a result, the stability of hepatocytes increases to the action of lipid peroxidation, which occurs when exposed to toxic ethanol products. The detoxification effect of metadoxin is due to the activation of liver enzymes, participating in the metabolism of ethanol (alcoholdeidrogendrogendrogen), what accelerates the process of elimination of ethanol and acetaldehyde from the body, and hence, their toxic effects are reduced.

Metadoxin prevents the accumulation of triglycerides in hepatocytes, prevents the formation of fibronctin and collagen, which significantly slows down the process of formation of cirrhosis of the liver.

The drug reduces the mental and somatic manifestations of a hangover syndrome, Reduces the time for removing withdrawal syndrome.

Metadoxin activates a cholinergic and Gaba-ergic neurotransmitter systems, improves the functions of thinking and short memory, prevents the occurrence of motor excitement, which is caused by ethanol.

Metadoxin has a non -specific antidepressant and anxiolytic effect, reduces alcohol attraction.

Pharmacokinetics

Absorption and distribution

After oral administration, the drug is quickly absorbed from the digestive tract and has high bioavailability (60-80%). Plasma protein binding – 50%.

Metabolism and excretion

It is metabolized in the liver to active metabolites – Piridina and Pirolidon Carboxyla. T_1/2 when taking oral or parenteral administration is 40-60 m. 45-50% the drug is excreted in the urine within 24 no, 35-50% excreted in the feces within 96 no.

Testimony

- toxic damage to the liver of alcoholic etiology;

- Prevention of the formation of cirrhosis of alcoholic origin;

— acute alcohol intoxication;

- Alcoholism;

- Alcohol withdrawal syndrome;

- decrease in alcohol attraction.

Dosage regimen

At acute alcohol intoxication Depending on the degree of intoxication, in/m is introduced 300-600 mg (5-10 ml) or / 300-900 mg (5-15 ml).

With V/in administration, the necessary dose of the drug is diluted in 500 ml of isotonic sodium chloride solution or 5% dextrose (Glucose) and introduce drip during 1.5 no.

Toxic damage to the liver of alcoholic etiology, Prevention of the formation of cirrhosis of alcoholic origin and chronic alcoholism: inwards 500 mg (1 tab.) 2 times / day (1 g / day) for 15-30 minutes before meals. The dose can be increased to 500 mg 3 times / day (1.5 g / day) or enter in/m in the dose 300 mg (5 ml)/d. A course of treatment – no less 90 days.

At alcoholic withdrawal syndrome iv in the form of infusion in a dose 900 mg (15 ml) 1 times / day for 3-7 days depending on the patient's condition.

Side effect

Maybe: allergic reactions. In patients with bronchial asthma, the development of bronchospasm is possible (When using a solution for injection).

Contraindications

- Pregnancy;

- Lactation (breast-feeding);

- Hypersensitivity to the drug.

Pregnancy and lactation

The use of the drug Metakoril during pregnancy and during lactation (breast-feeding) contraindicated.

Cautions

FROM caution The drug should be prescribed for Parkinson's disease, If levodop is used at the same time, tk. metadoxin reduces the effectiveness of the last.

The injection solution contains sodium metabisulfite. This substance can cause in patients, predisposed to asthmatic attacks (especially with bronchial asthma), Allergic reactions or strengthening of asthma attacks.

Overdose

Currently, cases of an overdose of the drug Metacorine have not been reported.

Drug Interactions

With the simultaneous use of metacoline, reduces the effectiveness of levodopa.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

List B. The drug should be stored out of reach of children, dark place at a temperature no higher than 25 ° C. Shelf life – 5 years.