Meat

When ATH:
V03AF01

Pharmacological action.
Reducing cytotoxicity oksazafosforinov, mucolytic.

Application.

Solution for injection: Prevention of the urotoxicity of cytostatics - derivatives oksazafosforinov, hemorrhagic cystitis, caused by alkylating agents.

The solution for inhalations: bronchial asthma, and chronic obstructive bronchitis, emphysema and lung atelectasis, bronchiectasis, Postoperative aspiration pneumonia in neurosurgical and thoracic surgery, in intensive care units (Prevention and treatment).

Nasal Spray: rhinitis, accompanied by a secret branch of difficulty (symptomatic treatment).

Contraindications.

Hypersensitivity (incl. other thiol compounds). The solution for inhalations: generalized weakness, ineffectiveness cough, asthma without thickening the mucus in the bronchial tree.

Side effects.

Dyspepsia (nausea, vomiting, diarrhea), hematuria, allergic reactions on the skin and mucous membranes. The solution for inhalations: cough, burning sensation and pain in the chest, bronchospasm.

Cooperation.

Incompatible in a single cisplatin infusion solution (It binds and inactivates it).

Dosing and Administration.

Solution for injection: Prevention of hemorrhagic cystitis induced by iphospamide - introduced in/in jet (slowly) 240 mg / m² or 20% the dose of cytostatic simultaneously with cytostatic and after 4 and 8 Chose Oksazaphosfort. For continuous infusion (24 no) cytostatic is administered at a dose 20% dose at the beginning of the cytostatic infusion, then dose 100% - During 24 h infusion and another 6-12 hours in the same dose - after the end of the infusion.

The solution for inhalations: inhalation, contents 1-2 ampoules (in pure form or in dilution 1:2 with water) 3-4 Times daily. Course - from several days to several weeks.

Endotracheal, 1–2 ml is dissolved in the same amount of distilled water or isotonic solution and introduced using a tube for tracheostomy or intra -vechery probe, repeating the procedure every hour until liquefaction and evacuation of secret. Instillation in the maxillary sinuses for sinusitis after lavage - 2-3 ml of undiluted solution every 2-3 days.

Nasal Spray: intranasally, in both nostrils, by 1 dose (one vprыskyvanyyu) 4 times / day.

Precautions.

Due to the presence of impurities in vials benzyl alcohol should not be used in infants and babies, but can be used with caution in the treatment of elderly patients.

Cautions.

Of unused contents of the vial should be discarded, tk. it is rapidly oxidized. Multidose vials can be stored 8 days.

Cooperation