Meropenem

When ATH:
J01DH02

Characteristic.

Synthetic carbapenem antibiotic from the group. Soluble in 5% solution of potassium hydroxyphosphate, poorly soluble in water, ethanol, practically insoluble in acetone.

Pharmacological action.
Antibacterial, bactericide.

Application.

Infection: respiratory tract and lungs (including hospital pneumonia), urinary system, abdomen, gynecological, skin and soft tissue; meningitis, septicemia, empirical therapy for suspected bacterial infection in adult patients with neutropenia (monotherapy or in combination with protivovirusnыmi or protivogribkovыmi preparatami).

Contraindications.

Hypersensitivity, incl. other beta-lactam antibiotics, infancy (to 3 Months).

Pregnancy and breast-feeding.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

At the time of treatment should stop breastfeeding.

Side effects.

Insomnia, hypererethism, anxiety, depression, disturbance of consciousness, hallucinations, epileptiform seizures, paresthesia, heart failure, Rituals- or bradycardia, Hypo- or hypertension, syncope, myocardial infarction, thromboembolism pulmonary artery branches, dyspnoea, nausea, vomiting, diarrhea, epigastric pain, psevdomembranoznыy colitis, cholestatic hepatitis, dizurija, swelling, violation of kidney function, hematuria, anemia, eozinofilija, neutropenia, thrombocytopenia or thrombocythemia, elevated liver enzymes (IS, GOLD, Alkaline phosphatase, LDH) and bilirubin levels, Positive Coombs, kandidomikoz, allergic reactions (skin rashes, itch, hives, angioedema, anaphylactic shock), injection site reactions (phlebitis, tromboflebit).

Cooperation.

Probenecid slows down, increases the concentration in plasma.

Dosing and Administration.

B /. Adults 500 mg every 8 no, When hospital-acquired infections — 1 g 3 once a day, meningitis is 2 g every 8 no. When Cl creatinine 26 to 50 mL/min dose-0.5-2 g every 12 no, from 10 to 25 ml / min - 1/2 the recommended dose every 12 no, less 10 ml / min - 1/2 normal dose 1 once a day.

Babies: from 3 Months before 12 years is 10-12 mg/kg every 8 no, with meningitis — 40 mg / kg 3 once a day.

B / in can be administered as a bolus, While divorces rate of 5 mL of solvent (isotonic sodium chloride solution or 5% glucose) on every 250 mg and injected during 5 min or drip infusion in the form of: soluble in 50-250 ml of solvent and is entered for 15-30 min.