Megestrol

When ATH:
G03DB02

Characteristic.

White crystalline solid, solubility in water at 37 °C 2 mg / ml, plasma- 24 mg / ml.

Pharmacological action.
Antitumor, gestagenic, antikahekticheskoe.

Application.

Disseminated mammary cancer, recurrent inoperable cancer of the endometrium, ovarian cancer, prostate cancer (palliative care); anorexia, cachexia and significant (for no apparent reason) weight loss in AIDS patients, cachexia have incurable cancer patients.

Contraindications.

Recurrent thrombophlebitis, pregnancy (first 4 Months).

Side effects.

Bleeding from the vagina, fluid retention, trombofilicescie state, the syndrome itsenko-Kushinga, pain in the abdomen and chest, constipation, dry mouth, gepatomegaliya, cardiomyopathy, depression, paresthesia, convulsions, breathlessness, cough, thromboembolism of small branches of the pulmonary artery, alopecia, giperglikemiâ, pituitary-adrenal disorders.

Dosing and Administration.

Inside, mono- or reception 2-4. Disseminated breast cancer -daily dose of 160 mg, endometrial cancer — 160-320 mg, anorexia and cachexia -400-800 mg.

Precautions.

To solve the question of the appointment of breast cancer should be after the determination of the binding of estrogen receptor and / or progesterone tumor cells. Before starting treatment for cachexia should be carried out a detailed examination to establish the cause of weight loss.