Meʙendazol

When ATH:
P02CA01

Characteristic.

Anthelmintics broad spectrum. Whitish-yellowish powder, slightly soluble (less 0,05%) in water, aqueous solutions of mineral acids, alcohol and chloroform, good - in ant acid. Molecular weight 295,29.

Pharmacological action.
Anthelmintic.

Application.

Эnterobyoz, askaridoz, ancylostomiasis, strongiloidoz, tryhotsefalez, multiple nematosis, echinococcosis, tenioz, alveokokkoz, capillariasis, hnatostomoz, trichinosis, mixed helminthiases.

Contraindications.

Hypersensitivity, nespetsificheskiy yazvennыy colitis, Crohn's disease, hepatic failure, pregnancy, lactation, Children up to age 2 years.

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

At the time of treatment should stop breastfeeding.

Side effects.

Dizziness, nausea, abdominal pain. When used in high doses for a long time: vomiting, diarrhea, headache, increase in liver transaminases, giperkreatinemiя, leukopenia, anemia, eozinofilija, hair loss, hematuria, цilindrurija, allergic reactions (skin rash, hives, angioedema).

Cooperation.

Carbamazepine and Others induktorы metabolism ponizhayut, and cimetidine - increases concentration in the tissues.

Overdose.

Symptoms: nausea, vomiting, diarrhea, abdominal pain. Prolonged use of high doses: reversible liver function abnormalities, hepatitis, neutropenia.

Treatment: gastric lavage, enema, administration of activated charcoal; No specific antidote.

Dosing and Administration.

Inside. When enterobioze: adults and children over 10 years - 100 mg dose, Children 2-10 years old - 25-50 mg once. In case of high probability of repeated invasion - repeatedly after 2–4 weeks in the same doses. It is recommended that simultaneous treatment of all family members.

When ascaridosis, tryhotsefaleze, ankilostomidoze, tenioze, strongiloidoze and mixed helminthiasis: by 100 MG in the morning and evening for 3 days.

When trichinosis: 200–400 mg 3 twice a day for 3 days, And with 4th by 10-400-500 mg 3 once a day.

When echinococcosis: by 500 mg 2 first times daily 3 day and 3 twice a day in the subsequent 3 day. Subsequently the dose was increased to a maximum (Based on 25-30 mg/kg/day) 3-4 reception.

Precautions.

Be sure to periodically smear the anal area and feces after treatment: treatment is considered effective when there is no helminth or their eggs for 7 next days. You should avoid sharing drinking alcohol and fatty foods, laxatives. It should monitor the peripheral blood picture, liver and kidney function.