When ATH:


Hormonal agents (glucocorticoids). The water-soluble synthetic derivative of prednisolone.

Pharmacological action.
Glucocorticoid, anti-inflammatory, antiallergic, immunosuppressive, protivoshokovoe.


Shock (ambustial, traumatic, operating, toxic, cardiogenic) after failure of other treatment; allergic reactions (sharp, severe), transfusion shock, anaphylactic shock; anaphylactoid reactions; swelling of the brain (incl. amid brain tumor or associated with surgery, radiotherapy or head injury); bronchial asthma (severe form), asthmatic status; systemic connective tissue disease (systemic lupus erythematosus, rheumatoid arthritis); acute adrenal insufficiency; thyrotoxic crisis; acute hepatitis, pechenochnaya coma; poisoning cauterizing liquids (decrease inflammation and prevent scarring restrictions).


Hypersensitivity (for short-term use of the system for health). Long-term treatment: gastric ulcer or duodenal ulcer in the acute phase, Cushing's syndrome, diabetes decompensated, expressed osteoporosis, psychosis, severe hypertension, acute infectious diseases, tuberculosis (without appropriate chemotherapy), during vaccination (increased risk of infections, especially children — including. kor, herpes), an increased risk of thromboembolism, glaucoma, systemic mycosis, decompensated cirrhosis of the liver with portal hypertension, decompensated heart failure, end-stage renal failure with syndrome of renal osteodystrophy, pregnancy, lactation; the neonatal period (due to the presence in the composition of benzyl alcohol).

Pregnancy and breast-feeding.

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects.

The frequency and severity of side effects depend on the duration of use, the value of the dosage used and the possibility of compliance circadian rhythm of destination.

Endocrine and metabolic: Cushing's syndrome, steroidnыy diabetes, glycosuria, obesity, atrophy of the adrenal cortex, menstrual disorders, negative nitrogen balance.

Cardio-vascular system and blood (hematopoiesis, hemostasis): arterial hypertension, vasculitis, leukocytosis.

From the nervous system and sensory organs: sleep disorders, psychosis, steroidnaya cataracts.

From the digestive tract: erosive and ulcerative lesions of the gastrointestinal tract.

On the part of the musculoskeletal system: osteoporosis, steroidnaya myopathy, decrease in muscle mass.

For the skin: slow process of wound healing, itching, rash, dryness and skin atrophy, gipopigmentatsiya, hypertryhoz, ecchymosis.

Other: fluid retention, decrease resistance to infections, withdrawal, kaliopenia, hypocalcemia.


It weakens the effect of antidiabetic agents, enhances — anticoagulants, cardiac glycosides (incl. toxic), ulzerogennosti NSAIDs, the risk of hypokalemia during treatment with amphotericin B, laxatives, Diuretics. Ethacrynic acid increases the risk of bleeding in the gastrointestinal tract, Inductors of microsomal oxidation (phenobarbital, difengidramin, phenytoin, rifampicin and the like.) negate glucocorticoid activity, some antimalarials, Estrogens, methandienone is reinforcing its, latest, Besides, reduces the severity of certain complications (osteoporosis, negative nitrogen balance).

Dosing and Administration.

B / (bolus or slow infusion), / m.

The route of administration and dosage regimen are selected individually depending on the nature and severity of the disease, patient's condition and response to therapy.

The recommended single dose for adults is 30-45 mg, in urgent situations (shock, asthmatic status, etc.) -150-300 mg, children, depending on age.


In view of the circadian rhythm of endogenous secretion of the main GC dose should be administered in the morning. Discontinuation of therapy should be gradually, initially reducing the dose, received in the evening and daytime hours. Required regular monitoring of blood pressure, the cells of peripheral blood, blood glucose levels of electrolytes and. Elderly and debilitated patients with long-term treatment is indicated supplementation of anabolic steroids.

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