Mafenid

When ATH:
D06BA03

Characteristic.

Methylated sulfanilamide, topical. White or white with Valium a white crystalline powder. Easily soluble in water, slightly soluble in ethyl alcohol, practically insoluble in chloroform.

Pharmacological action.
Broad-spectrum antibacterial, bacteriostatic, antifungal.

Application.

Infected burns II and III level, sores, bedsores, sores.

Contraindications.

Hypersensitivity, toxic and allergic reactions to sulfonamides history, during childbirth.

Restrictions apply.

Deficiency of glucose-6-fosfatdegidrogenazы (the risk of hemolytic anemia and disseminated intravascular coagulation), blood dyscrasias, impaired function of the lungs and kidneys (metabolicheskogo acidosis risk), pregnancy, lactation, premature babies, Age to 2 Months (the risk of kernicterus).

Pregnancy and breast-feeding.

Use in pregnancy is not recommended, if the area of ​​the burn does not exceed 20% body surface. Contraindicated during childbirth. At the time of treatment should stop breastfeeding.

Side effects.

Local irritating, burning and pain in the wound (lasting from 20-30 minutes to 1-3 hours); metabolic acidosis (especially in violation of lung and kidney function), diapedetic hemorrhage, allergic reactions; when the vast area affected, and, Consequently, substantial suction-Stevens-Johnson Syndrome, Lyell's syndrome, blood dyscrasias, incl. gemoliticheskaya anemia, kristallurija.

Dosing and Administration.

Locally: put directly on the wound surface layer 1,5 mm, leaving it open or applying a bandage, impose napkins with a layer of wax 2-3 mm to well-cleaned from gnano-nekroticeskih masses wound, administered ointment impregnated tampons in cavities. Typically spend 30-70 g ointment on one bandage. Change of dressings is carried out 1 once a day or 2-3 times per week, depending on the amount of purulent discharge. Duration of treatment 1-5 weeks (until, until the affected area does not heal or is ready for transplantation). With burns of II degree possible once bandaging.

Precautions.

If the bandage with ointment stuck to the wound surface, before removing it is recommended soak antiseptic solution in order to avoid traumatizing the surface epithelium, accompanied by bleeding wound surface. During treatment requires monitoring of acid-base balance in patients with extensive burns, impaired lung and kidney. Perhaps the manifestation of cross-hypersensitivity with furosemide, thiazide diuretics, sulfonylurea and carbonic anhydrase inhibitors. When severe pain in the wound is recommended to appoint analgesics.

Cautions.

If the patient's movement, after taking a bath or shower mafenid removed from affected areas, should apply it again.