Cat yellow – Glautsinum yellow – Glaucium yellow Crantz.
Herbaceous plants papaveraceous (Papaveraceae). Medical raw material is the aboveground part.
The chemical composition of Maçka yellow
The yellow grass Maçka detected amount of alkaloids (derivatives izoxinolina) with the highest content in it glaupina. Also glaucine, a plant found aurotenzin, koridin, izokoridin, xelidonin, allokryptopyn, xeliruʙin, sangvinarin, xeleritrin, protopine and others.
The pharmacological properties of Maçka yellow
Glaucine hydrochloride is characterized by pronounced antitussive activity. In experiments on the cats at a dose of drug was 0,5 mg / kg causes a depression of the cough reflex, occurs when an electric current stimulation of the upper laryngeal nerve. At a dose of 1 mg / kg of the drug effect is amplified and lasts about 1 no. At a dose of 2 3 mg / kg of complete sets off the cough reflex for 1-3 hours. Glaucine lengthens sleep, called geksenalom and chloral hydrate, and provides a clear analgesic effect. The drug causes inhibition in the experiment motor-defense reflexes and muscle relaxation of the central phenomenon.
Glaucine has a marked effect adrepoliticheskoe: In acute experiments on various types of laboratory animals reduces pressor response in response to intravenous vvedenieadrenalina, and reduces the uterine contractions and the effect of adrenaline on the peripheral vascular tone of isolated organs. Prevents death when administered intraperitoneally 50 % white mice from a lethal dose of adrenaline. In effect adrepoliticheskomu glaucine slightly inferior redergamu. However glaucine no significant effect on peripheral m- and n-holinoreaktivnye.
The drug is administered intravenously at a dose of 1-5 mg / kg reduces blood pressure by 10-50 % compared with baseline, as well as off the reflexes, arising from the circulation and respiration during cross-clamping the common carotid artery and .razdrazhenii electrocution central segments of the vagus nerve and the tibial.
When studying the effect on smooth muscle glaucine set ^, in a dose of 3-10 mg / kg, it causes a decrease in tone, reduces peristalsis and relaxes the muscles of the uterus. The drug has low toxicity.
Application Maçka yellow medicine
Therapeutic efficacy glaucine studied in clinical settings for various pulmonary .zabolevaniyah. Glaucine appointed by 1 2 tablet 3 times a day for 3-7 days with acute respiratory diseases, Ostrom bronchi, ʙronxopnevmonii, lobar pneumonia, hronicheskom bronchi, lung abscess, fibronodular pulmonary tuberculosis, exudative pleurisy and other respiratory diseases.
A positive result is usually observed in the 2-3-day treatment. Patients discontinued cough for several hours or decrease its frequency and intensity, easier sputum. In some patients, the cough stops completely with 3-5-day treatment glaucine. The therapeutic effect is more pronounced for acute processes.
Pulse, BP in normotensive unchanged, but with hypertension 50 % patients with a decrease in blood pressure. By the force and duration of the antitussive effect of codeine glaucine more active. It has no inhibitory effect on respiration, side effects on the gastrointestinal tract and does not cause addiction and addiction to it. Antihypertensive properties of the preparation are expressed slightly and continue a short time. Noticeable effect on normal or low blood pressure drug has no. After receiving glaucine possible slight dizziness, disappears after 10-15 minutes.
The results of clinical studies indicate a high therapeutic efficacy glaucine respiratory diseases.
Formulations, Dosage and administration of drugs Maçka yellow
Glaucine hydrochloride (Glaucine hydrochloride) - White or light cream crystalline powder. When exposed to light coloring intensifies. Soluble in water, it is difficult - in alcohol.
Assign inside: adult on 0,05 g (50 mg) 2-3 times daily after meals, children - 0.01-0.03 g.
