Lynestrenol (When ATH G03AC02)

When ATH:
G03AC02

Pharmacological action.
Progestogens .

Application.

Dysfunctional uterine bleeding, amenorrhea (primary or secondary), spanomenorrhea, endometriosis, cancer endometrio, mastopathy, premenstrual syndrome, postponement of normal ovulation. Oral contraception during lactation and contraindication of estrogen.

Contraindications.

Hypersensitivity, severe liver, uterine bleeding unknown etiology, itch, porphyria, otosclerosis, heart failure, arterial hypertension, depression, trombofilicescie state, intrahepatic cholestasis, inborn errors of metabolism of bilirubin, insulin-dependent diabetes mellitus, pregnancy, incl. ectopic (history).

Side effects.

Bleeding "breakthrough" or spotting from the genital tract, girsutizm, chloasma, changes in libido, nausea, diarrhea, headache, dizziness, nervousness, depression, chest pain, weight gain, reduced glucose tolerance, changes in the level of bilirubin, transaminases, prothrombin index, lipoprotein profile, Genital candidiasis, acne, itching.

Cooperation.

Barbiturates, rifampicin, laxatives reduce the effectiveness of contraception. Macrolides increase the risk of liver toxicity. Increases plasma concentration of beta-blockers, and cyclosporine.

Overdose.

Symptoms: nausea and vomiting.

Treatment: symptomatic.

Dosing and Administration.

Inside. In endometriosis, dysfunctional uterine bleeding is 5-15 mg per day long course (no less 6 Months). When premenstrual syndrome — 5 mg/day with 14 by 25 Day cycle. When the endometrium is 30-50 mg/day. Amenorrhea is usually prescribed after estrogenic preparation of endometrium on 5-10 mg per day in the second half of the cycle. For contraception every day, from 1 by 28 day cycle 0,5 mg per day in one and the same time.

Precautions.

With prolonged use is necessary periodic monitoring of blood clotting, lipid and carbohydrate metabolism, bilirubin, transaminases. It is recommended to limit intake of fats, carbohydrates (Confectionery), which is especially important for women with an initial excess body weight. With the trend towards hypertension should be controlled blood pressure (reduce fluid intake to 1.5-2 liters per day), in insulinzawisimom diabetes — Glycemic profile (may require increased doses of insulin). In the case of dysfunctional uterine bleeding in women of reproductive age it is recommended to start treatment after treatment and diagnostic curettage of the uterus. The ineffectiveness of hormone therapy (recurrent bleeding and endometrial hyperplasia) It requires clarification reasons bleeding. At long delay menstruation during therapy should be excluded ectopic pregnancy. It is necessary to take into account, that reliable contraception is significantly reduced when the irregular admission, as well as vomiting and diarrhea.