Lornoxicam

When ATH:
M01AC05

Pharmacological action.
Anti-inflammatory, analgesic, pyretic, antiagregantnoe.

Application.

Arthritis: rheumatoid, psoriatic, acute gouty, infectious; systemic lupus erythematosus (light shaped articular syndrome, without kidney damage), reactive synovitis program deforming osteoarthritis, ankylosing spondylitis, radicular syndrome in osteochondrosis, işialgii; pain: Menstrual, Toothbrush, post-operative and post-traumatic.

Contraindications.

Hypersensitivity, severe bleeding from the gastrointestinal tract, gastric ulcer and duodenal ulcer, incl. history, prostaglandin asthma, inflammatory bowel disease, leukopenia, thrombocytopenia, the liver and kidneys, congestive heart failure, severe hypertension, pregnancy, lactation, children's, youthful (to 18 years) and old age.

Side effects.

Nausea, vomiting, abdominal pain, heartburn, flatulence, diarrhea, dry mouth, decreased appetite, gastritis, esophagitis, erosive and ulcerative lesions of the mucous membrane of the stomach and intestines, bleeding from the gastrointestinal tract, nose bleed, abnormal liver function, dizurija, reduction in glomerular filtration rate, acute renal failure, interstitial nephritis, papillary necrosis, headache, dizziness, drowsiness, depression (or excitement), arterial hypertension, tachycardia, sodium and water retention, peripheral edema, tremor, Sweating, leukopenia, thrombocytopenia, aseptic meningitis, skin rashes, injection site reactions (hyperemia, soreness).

Cooperation.

Side effects from the gastrointestinal tract are reduced with misoprostol. Other NSAIDs increase the risk of side effects, indirect anticoagulants - bleeding. Increases hypoglycemic activity of derivatives sulfonylureas. It weakens the diuretic effect and increases the nephrotoxicity of diuretics, It reduces - antihypertensive drugs. Reduces the renal clearance of digoxin. Increases plasma concentration of lithium preparations. Against the background of cimetidine increases blood levels of lornoxicam.

Overdose.

Symptoms: increased side effects from the central nervous system and gastrointestinal tract, increased blood pressure, cardiac and / or acute renal failure.

Treatment: gastric lavage, appointment of activated carbon, monitoring and maintenance of vital functions. Dialysis nyeeffyektivyen.

Dosing and Administration.

Inside, / m, I /. Inside, before a meal with a sufficient quantity of liquid, at an initial dose 16 mg, with a gradual increase in its, the maximum dose in the first day - to 32 mg; then - on 8 mg 2 once a day. For the relief of acute pain (lyumbago, podagricheskaya attack, post-traumatic pain) - I / O for 15 from, or / m, at a dose of 8-16 mg (solution is prepared time, spreading the contents of the vial 2 ml water for injection).

Precautions.

When anamnestic indication of the erosive and ulcerative lesions of the gastrointestinal tract lornoxicam can be used only in conjunction with H₂-blockers and proton pump inhibitors. Chronic administration requires regular monitoring of blood pressure (especially in patients with hypertension), Peripheral Blood, glomerular filtration rate, transaminase levels. Be wary appoint elderly and debilitated patients. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cooperation