LOFOKS (Eye drops)

Active material: Lomefloxacin
When ATH: S01AX17
CCF: Fluoroquinolone antibacterial drug for topical application in ophthalmology
ICD-10 codes (testimony): A74.0, H01.0, H10.2, H10.4, H10.5
At KFU: 06.17.02.03
Manufacturer: Synthesis of (Russia)

Pharmaceutical form, composition and packaging

Eye drops 0.3% a transparent or slightly opalescent liquid, colorless or light yellow.

Excipients: distilled glycerol, disodium edetate (disodium эdetat), benzalkonium chloride, Sodium hydroxide (1 M solution of), water d / and (to 1 ml).

5 мл – флакон-капельницы полиэтиленовые (1) – пачки картонные.

Pharmacological action

Antibacterial drug broad-spectrum fluoroquinolones from the Group, diphthorquinolone. It has bactericidal activity, the mechanism of which is associated with the effect on the DNA gyrase of bacteria, providing supercoiling. Lomefloxacin forms a complex with its tetramer (subunit of gyrase A2B2) and disrupts DNA transcription and replication, which leads to the death of a microbial cell. Β-lactamases produced by pathogens do not affect the activity of lomefloxacin.

Preparation highly active against gram-negative aerobic microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter different, Klebsiella pneumoniae, Enterobacter cloacae, Proteus vulgaris, Salmonella spp., Shigella spp., Moraxella catarrhalis, Morganella morganii, Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila.

C drug moderately sensitive: Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Serratia dissolving, Serratia wilting, Mycobacterium tuberculosis, Chlamydia trachomatis, Hafnia avenue, Citrobacter freundii, Aeromonas hydrophila, Proteus is wonderful, Proteus stuartii, Rettgeri Providence, Alcalifaciens Providence, Klebsiella oxytoca, Klebsiella ozaenae, Enterobacter aerogenes, Enterobacter agglomerans.

C drug resistant: Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Treponema pale, Mycoplasma hominis and anaerobic bacteria.

Pharmacokinetics

After instillation by 1 drop 1 times / day for 2 days and 5 drops to 3 day T_max – 90 m, C_max – 1 μg / ml for 2.5 no. Therapeutic concentration in the cornea, the sclera, century, the conjunctiva and intraocular fluid is achieved after 5 instillations by 1 drop at intervals 5 m. Content in the tear fluid after 1-2 instillations is: 40-200 ug / mL in 2 no, 7-27 ug / mL in 6 h or more, 3 ug / mL in 24 no.

Testimony

- infectious and inflammatory diseases of the anterior part of the eye, caused by susceptible microorganisms (conjunctivitis, .Aloe, blefarokonъyunktyvyt, incl. chlamydial infection).

Dosage regimen

Adults appoint 1 drop 2-3 times / day in the lower conjunctival sac for 7-9 days. At the beginning of treatment, more frequent use is necessary: 5 drops during 20 m (by 1 drop at intervals of 5 m) or 1 drop / h during 6-10 no.

Side effect

Local reactions: burning sensation; при длительном применении – развитие вторичной грибковой инфекции.

Contraindications

- Pregnancy;

- Lactation (breast-feeding);

— childhood and adolescence;

- Hypersensitivity to the drug.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation (breast-feeding).

Cautions

Wearing contact lenses should be avoided during treatment.

Overdose

Data on overdose of the drug Lofox^® in the form of eye drops are not provided.

Drug Interactions

Data on drug interactions of the drug Lofox^® in the form of eye drops are not provided.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

List B. The drug should be stored out of reach of children, dark place at a temperature of 15 ° to 25 ° C. Do not freeze! Shelf life - 2 year.

После вскрытия флакона срок хранения – 1 month.