LOFOKS (Eye drops)
Active material: Lomefloxacin
When ATH: S01AX17
CCF: Fluoroquinolone antibacterial drug for topical application in ophthalmology
ICD-10 codes (testimony): A74.0, H01.0, H10.2, H10.4, H10.5
At KFU: 06.17.02.03
Manufacturer: Synthesis of (Russia)
Pharmaceutical form, composition and packaging
Eye drops 0.3% a transparent or slightly opalescent liquid, colorless or light yellow.
| 1 ml | |
| lomefloxacin (the hydrochloride) | 3 mg |
Excipients: distilled glycerol, disodium edetate (disodium эdetat), benzalkonium chloride, Sodium hydroxide (1 M solution of), water d / and (to 1 ml).
5 ml – dropper bottle plastic (1) – packs cardboard.
Pharmacological action
Antibacterial drug broad-spectrum fluoroquinolones from the Group, diphthorquinolone. It has bactericidal activity, the mechanism of which is associated with the effect on the DNA gyrase of bacteria, providing supercoiling. Lomefloxacin forms a complex with its tetramer (subunit of gyrase A2B2) and disrupts DNA transcription and replication, which leads to the death of a microbial cell. Β-lactamases produced by pathogens do not affect the activity of lomefloxacin.
Preparation highly active against gram-negative aerobic microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter different, Klebsiella pneumoniae, Enterobacter cloacae, Proteus vulgaris, Salmonella spp., Shigella spp., Moraxella catarrhalis, Morganella morganii, Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila.
C drug moderately sensitive: Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Serratia dissolving, Serratia wilting, Mycobacterium tuberculosis, Chlamydia trachomatis, Hafnia avenue, Citrobacter freundii, Aeromonas hydrophila, Proteus is wonderful, Proteus stuartii, Rettgeri Providence, Alcalifaciens Providence, Klebsiella oxytoca, Klebsiella ozaenae, Enterobacter aerogenes, Enterobacter agglomerans.
C drug resistant: Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Treponema pale, Mycoplasma hominis and anaerobic bacteria.
Pharmacokinetics
After instillation by 1 drop 1 times / day for 2 days and 5 drops to 3 day Tmax – 90 m, Cmax – 1 μg / ml for 2.5 no. Therapeutic concentration in the cornea, the sclera, century, the conjunctiva and intraocular fluid is achieved after 5 instillations by 1 drop at intervals 5 m. Content in the tear fluid after 1-2 instillations is: 40-200 ug / mL in 2 no, 7-27 ug / mL in 6 h or more, 3 ug / mL in 24 no.
Testimony
- infectious and inflammatory diseases of the anterior part of the eye, caused by susceptible microorganisms (conjunctivitis, .Aloe, blefarokonъyunktyvyt, incl. chlamydial infection).
Dosage regimen
Adults appoint 1 drop 2-3 times / day in the lower conjunctival sac for 7-9 days. At the beginning of treatment, more frequent use is necessary: 5 drops during 20 m (by 1 drop at intervals of 5 m) or 1 drop / h during 6-10 no.
Side effect
Local reactions: burning sensation; prolonged use – development of a secondary fungal infection.
Contraindications
- Pregnancy;
- Lactation (breast-feeding);
— childhood and adolescence;
- Hypersensitivity to the drug.
Pregnancy and lactation
The drug is contraindicated during pregnancy and lactation (breast-feeding).
Cautions
Wearing contact lenses should be avoided during treatment.
Overdose
Data on overdose of the drug Lofox® in the form of eye drops are not provided.
Drug Interactions
Data on drug interactions of the drug Lofox® in the form of eye drops are not provided.
Conditions of supply of pharmacies
The drug is released under the prescription.
Conditions and terms
List B. The drug should be stored out of reach of children, dark place at a temperature of 15 ° to 25 ° C. Do not freeze! Shelf life – 2 year.
After opening the bottle shelf life – 1 month.
