LIKOPID
Active material: gljukozaminilmuramildipeptid
When ATH: L03AX
CCF: Immunostimulatory drug
ICD-10 codes (testimony): A15, B00, B00.5, B02.3, B18.1, B18.2, B97.7, J15, J31, J32, J35.0, J37, J42, L01, L02, L03, L08.0, L40, T79.3
When CSF: 14.01.06
Manufacturer: PEPTEK Company (Russia)
Pharmaceutical form, composition and packaging
Pills white, round, Valium, chamfered.
| 1 tab. | |
| GMDP (gljukozaminilmuramildipeptid) | 1 mg |
Excipients: lactose, sucrose, potato starch, methyl cellulose, calcium stearate.
10 PC. – packings Valium planimetric (1) – packs cardboard.
10 PC. – packings Valium planimetric (2) – packs cardboard.
Pills white, round, Valium, a facet and Valium.
| 1 tab. | |
| GMDP (gljukozaminilmuramildipeptid) | 10 mg |
Excipients: lactose, sucrose, potato starch, methyl cellulose, calcium stearate.
10 PC. – packings Valium planimetric (1) – packs cardboard.
10 PC. – packings Valium planimetric (2) – packs cardboard.
Pharmacological action
Immunostimulatory drug, Biological activity is due to the presence endoplasma phagocytes and T-lymphocyte receptors GMDP.
The drug stimulates the functional (baktericidnuю, cytotoxic) activity of phagocytes (neutrophil, macrophages), enhances T cell proliferation- and in- lymphocytes, It increases the synthesis of specific antibodies.
The pharmacological action is carried out by strengthening production of interleukin (Interleukin-1, Interleukin-6, IL-12), Tumor Necrosis Factor, alpha and gamma-interferon, colony stimulating factors.
The drug increases activity of natural killer cells.
Pharmacokinetics
Absorption and distribution
Cmax of active substance in plasma achieved through 1.5 h after administration. Oral bioavailability is 7-13%.
The degree of binding to blood albumin weak.
Metabolism and excretion
Active metabolites does not form.
T1/2 is 4.29 no. Excreted unchanged, mostly in the urine.
Testimony
In the combined therapy of states, accompanied by secondary immunodeficiency, including:
Pills 1 mg 10 mg (for adults)
- Chronic infections of the upper and lower respiratory tract;
- Acute and chronic purulent-inflammatory diseases of the skin and soft tissues (incl. postoperative septic complications);
- With herpes infection (incl. when oftalmogerpese);
- When papillomovirusnoy infection;
- In chronic viral hepatitis B and C;
- Psoriasis (incl. when Arthropathic form);
- Pulmonary tuberculosis.
Pills 1 mg (for children)
- Acute and chronic purulent-inflammatory diseases of the skin and soft tissues;
- Chronic infections of the upper and lower respiratory tract, both in the acute stage, and in remission;
- If any localization of herpes infection;
- In chronic viral hepatitis B and C.
Dosage regimen
Likopid® administered sublingually or inside an empty stomach, for 30 minutes before eating.
Adults to prevention of postoperative complications Likopid® sublingually administered by 1 mg 1 times / day for 10 days.
To treatment of septic processes of the skin and soft tissues of medium gravity (incl. postoperative) Likopid® sublingually administered by 2 mg 2-3 times / day for 10 days.
To treatment of severe septic processes of the skin and soft tissues Likopid® appointed interior 10 mg 1 times / day for 10 days.
At Chronic infections of the upper and lower respiratory tract Likopid® sublingually administered by 1-2 mg 1 times / day for 10 days.
At pulmonary tuberculosis Likopid® appointed interior 10 mg 1 times / day for 10 days.
At mild form herpes infection Likopid® sublingually administered by 2 mg 1-2 times / day for 6 days; at severe – by sublingual 10 mg 1-2 times / day for 6 days. At oftalmogerpese Likopid® administered orally at 10 mg 2 times / day for 3 days. After a break 3 day treatment repeat.
At lesions of the cervix with human papillomavirus Likopid® appointed interior 10 mg 1 times / day for 10 days.
To treatment of psoriasis Likopid® administered orally at a dose 10-20 mg 1-2 times / day for 10 days and then every other day 10-20 mg for the next 10 days, at severe and a large area of injury (incl. when Arthropathic form) – inside 10 mg 2 times / day for 20 days.
Children aged 1 Year to 16 years Likopid® administered in tablet form 1 mg.
At treating chronic respiratory infections and chronic inflammatory diseases of the skin Likopid® administered orally at a dose 1 mg 1 times / day for 10 days.
At the treatment of herpes infections drug prescribed oral dose 1 mg 3 times / day for 10 days.
At treatment of chronic viral hepatitis B and C – oral dose 1 mg 3 times / day for 20 days.
Newborns at protracted course of infectious diseases (incl. pneumonia, bronchitis, enterocolitis, sepsis, postoperative complications) Likopid® administered orally at a dose 500 g 2 times / day for 7-10 days.
Side effect
Maybe: at the beginning of treatment – increase in body temperature up to 37.9 ° C (is short-lived, It runs independently and does not require discontinuation of the drug).
Contraindications
- Autoimmune thyroiditis in the acute phase;
- Diseases, accompanied by high fever or hyperthermia (>38° C);
- Pregnancy;
- Lactation (breast-feeding);
- Hypersensitivity to the drug.
Pregnancy and lactation
Use of the drug during pregnancy and lactation (breast-feeding) contraindicated.
Cautions
It is not appropriate joint appointment Likopid® with sulfanilamidnymi drugs and tetracyclines.
Effects on ability to drive vehicles and management mechanisms
Use of the drug Likopid® It has no effect on the ability to perform work, require increased attention and psychomotor speed reactions.
Overdose
Currently, cases of drug overdose Likopid® not reported.
Drug Interactions
In an application Likopid® It increases the effect of antibiotics from the group of semi-synthetic penicillins, cephalosporins, polyene derivatives, fluoroquinolones, marked synergy with antiviral and antifungal agents.
Antacids and adsorbents while the use of Likopid® significantly reduce its bioavailability.
GCS while the application reduce the effectiveness Likopid®.
Conditions of supply of pharmacies
The drug is released under the prescription.
Conditions and terms
List B. The drug should be stored in a dry, protected from light, inaccessible to children at temperature not exceeding 25 ° C. Shelf life – 5 years.
