Lekrolin

Active material: Cromoglicic acid
When ATH: S01GX01
CCF: Allergy drug for topical application in ophthalmology
ICD-10 codes (testimony): H10.1, H16.2
When CSF: 13.02.03.02
Manufacturer: Santen Oy (Finland)

Pharmaceutical form, composition and packaging

Eye drops as a clear solution, colorless or slightly yellowish.

Excipients: benzalkonium chloride, disodium эdetat, glycerol, polyvinyl alcohol, water d / and.

10 ml – dropper bottle plastic (1) – packs cardboard.

Eye drops as a clear, colorless or slightly yellowish solution.

Excipients: disodium эdetat, glycerol, polyvinyl alcohol, water d / and.

0.25 ml – tube-droppers (10) – three-layer laminated paper bags (2) – packs cardboard.

Pharmacological action

Allergy medication, Stabilizers fat cell membranes. It prevents mast cell degranulation and histamine release of these, bradykinin, leukotrienes (incl. slow reacting substance) and other biologically active substances.

The drug is most effective for prophylactic use.

Full clinical effect in patients with allergic diseases of the eye is achieved within a few days or weeks of treatment.

Pharmacokinetics

Absorption

When applying eye drops of sodium cromoglycate absorption through the mucous membrane of the eye is negligible.

Systemic bioavailability is less than 0.1%.

Deduction

T_1/2 is 5-10 m.

Testimony

- Allergic conjunctivitis;

- Allergic keratitis;

- Keratokonъyunktyvyt;

- Eye irritation, due to allergic reactions (Environmental factors, occupational hazard, household chemicals, cosmetics, ophthalmic preparations, pollen and pet dander).

Dosage regimen

The drug is prescribed for 1-2 drops into each conjunctival sac 4 times / day.

At seasonal allergic conjunctivitis treatment should be started immediately after the onset of symptoms or use prophylactically prior to the appearance of the pollen season. Treatment continued throughout the pollen season or longer, if symptoms persist.

Terms of Use lekrolin^® in tube-dropper

1. Open the package along the dotted line.

2. Detach one tube-dropper.

3. Carefully close the package.

4. Check, the solution is in the bottom of the tube-droppers and open tube-dropper.

5. Begin to drip 1 -2 Eye drops.

Dose, contained in a tube-dropper, sufficient for a single instillation into both eyes. After a single use tube-dropper should be discarded, even if the contents of the left.

Side effect

On the part of the organ of vision: > 1/100 – transient burning sensation, Local irritation of the eyes and quickly passing violation of clarity of vision.

Other: < 1/10 000 – allergic reactions.

Contraindications

- Children up to age 4 years;

- Hypersensitivity to the drug.

Pregnancy and lactation

During pregnancy and lactation (breast-feeding) drug should be used with caution and only if, when the intended benefits to the mother outweighs the potential risk to the fetus or infant.

Cautions

Eye drops Lekrolin^®, packaged in a bottle-dropper, soderzhat preservative benzalkonium chloride, which can cause eye irritation symptoms. Therefore, patients, wear contact lenses, should remove them before using drops and set back no earlier than 15 minutes after instillation.

Eye drops Lekrolin^®, packaged in a tube-dropper, intended for single use, It does not contain a preservative, so do not slow healing of conjunctival or corneal wounds. These droplets can be used in patients with hypersensitivity to preservatives, and in patients, using any type of contact lenses.

Do not touch the eye with the tip of the pipette.

The bottle must be closed after each use.

Effects on ability to drive vehicles and management mechanisms

Patients, who after instillation of the drug appears short break-definition visual perception, should not drive or operate machinery, machine or any other equipment, It requires clarity of vision, immediately after applying eyedrops.

Overdose

The local application of a drug overdose is unlikely. IN experimental studies shows, that the local and systemic toxicity kromoglitsievoy acid is very small.

Symptoms: possible nausea.

Treatment: symptomatic therapy.

Drug Interactions

There was no negative symptoms cromoglicic acid interactions with other drugs.

When applying cromoglicic acid may reduce the need to use ophthalmic preparations, containing corticosteroids.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

The drug should be stored out of reach of children, dark place at a temperature of 15 ° to 25 ° C. Shelf life – 3 year.

After opening the bottle, dropper or tube opening packet-droppers shelf life 1 Months.