Potbelly yellow – Nuphar lutea (L.) Smith

Perennial herb with creeping rhizome, reaches a length of 3-4 m, families kuvshinkovыh (Nymphaeaceae). It is widespread in almost all regions of Russia, with the exception of the Far North, The Far East and Central Asia. For medical purposes harvest rhizomes.

Potbelly yellow – Chemical composition

Rhizomes yellow egg capsules contain several structurally related alkaloids quinolizidine: nufaridin, tioʙinufaridin, neotiobinufaridin and nuflein, as well as sugar, resinous and bitter substances, starch, a group of compounds dubiliyh.

Potbelly yellow – Pharmacological properties

Specific pharmacological activity of the capsule yellow depends mainly on the content of the plant alkaloids, Dedicated sum - lyutenurin - well studied experimentally. Lyutenurin is antimicrobial broad-spectrum drugs, It inhibits the growth of Gram-positive, including antibiotic-resistant bacteria, and spore-forming and acid-fast bacilli and pathogenic fungi, including Candida species. The drug has protivotrihomonadnoy activity.

Lyutenurina bacteriostatic effect is most pronounced at a slightly alkaline pH of the medium, a bactericidal effect depends on the concentration of the drug and duration of contact with the agent. Lyutenurin not show bacteriostatic properties against Gram-negative microorganisms.

In experimental studies found, that lyutenurin on protivotrihomonadnyh properties are not inferior to other drugs protivotrihomonadnyh. The best results in the disease trnhomonadnyh white mice provides the combined use of flags with lyutenurinom.

Lyutenurin has a fairly strong spermicidal property.

When toxicological study found, that lyutenurin, administered in therapeutic doses, It does not cause pathological changes in the internal organs of experimental animals and does not affect the peripheral blood.

Potbelly yellow – Use in medicine

Lyutenurin used topically for the treatment of diseases of the skin and mucous membranes, caused by Gram-positive organisms and pathogenic fungi of the genus Candida. There was a therapeutic efficacy in otitis various etiologies, acute and chronic urogenital diseases trihomonadnyh, as well as in the treatment of trichomoniasis, complicated by bacterial and fungal flora. Besides, lyutenurin successfully used as a topical contraceptive.

As protivotrihomonadnyh means lyutenurin been studied in the treatment of women, patients with different forms of trnhomonadnyh diseases with different duration invasion, including unsuccessfully treated with other medications. It was established that a significant therapeutic efficacy of the drug, which manifests itself in improving the general condition of patients, the disappearance of clinical symptoms (itching and burning in the vagina, copious purulent discharge), normalize the function of the mucosa and disappearance of her swelling. Improvement occurred in most patients after 2-3 treatments. Purity vagina changed from III and IV to I and II. In some cases, there epithelialization of cervical erosion.

In 90 % Patients come complete cure trichomoniasis, laboratory-confirmed.

When treating lyutenurinom colpitis netrihomonadnoy etiology was also observed good results. Patients disappeared inflammation, uluchshalosy confidence.

Side effects: possible local irritant effect.

Contraindications: idiosyncrasy.

Potbelly yellow – Formulations, Dosing and Administration

Lyutenurin available as 0,5% liniment for external use, vaginal suppositories and foaming tablets, containing 3 mg. The solution lyutenurina prepared ex tempore on the double-distilled water. The drug is recommended to be applied topically in the form of 0,5 % liniment or 0.1-0.5 % aqueous solutions.

When used trbhomonadnyh infections 0,5 % liniment or vaginal suppositories lyutenurina. When treating women the vagina is treated with liniment daily or every other day. Suppositories are used as an additional tool in the intervals between treatments. The first course of treatment 10-12 days. Spend at least 3 rates.

As contraceptive use vaginal suppositories or foaming tablets, which are inserted into the vagina for 5-10 minutes before sexual intercourse. Tablets moisten with water before use.