KORTEKSIN

Active material: Cortexin dry extract
When ATH: N06BX
CCF: Nootropics
ICD-10 codes (testimony): F07, F07.2, F45.3, F48.0, F80, F81, G04, G40, G45, G80, G93.4, I61, I63, S06, T90
At KFU: 02.14.01.01
Manufacturer: GEROPHARM Ltd. (Russia)

Pharmaceutical form, composition and packaging

Valium for drug of a solution for the / m as a powder or porous mass of white or white with a yellowish tint; prepared solution of – clear, colorless or yellowish tint.

Excipients: glycine – 12 mg (stabilizer).

Vials 5 ml (10) – packs cardboard.

Pharmacological action

Nootropics.

It contains a complex of low molecular weight water-soluble polypeptide fractions with a molecular weight of not more than 10 Yes, isolated from the cerebral cortex of cattle or pigs under 12 months of age. It penetrates through the blood-brain barrier directly to the nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific action.

Nootropic action

It improves the higher functions of the brain, the processes of learning and memory, concentration, stability under various stress conditions.

The neuroprotective effect

It protects neurons from damage by various endogenous neurotoxic factors (Glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.

The antioxidant effect

It inhibits lipid peroxidation in neurons, increases neuronal survival in the conditions of oxidative stress and hypoxia.

Tissue-specific action

It activates the metabolism of neurons of the central and peripheral nervous system, repair processes, It helps to improve the functions of the cerebral cortex and the overall tone of the nervous system.

Mechanism of action

The mechanism of action Cortexin^® due to activation of neuronal peptide neurotrophic factors and brain; optimizing the balance of metabolism excitatory and inhibitory amino acids, dopamine, Serotonin; GABA-ergic influence; declining paroxysmal seizure activity in the brain, the ability to improve its bioelectric activity; preventing the formation of free radicals (lipid peroxidation products).

Pharmacokinetics

The complex structure of Cortexin^®, active substance which is a complex of polypeptide fractions, It does not allow normal pharmacokinetic analysis of individual components.

Testimony

In the treatment of these conditions and diseases:

- Cerebrovascular accident;

- Traumatic brain injury and its consequences;

- Encephalopathy different genesis;

- Cognitive impairment (incl. disorders of memory and thinking);

- Acute and chronic encephalitis and encephalomyelitis;

- Epilepsy;

- Asthenic conditions;

- Suprasegmental autonomic dysfunction (vascular dystonia);

- Decrease in the ability to learn;

- Delay of psychomotor and speech development in children;

- The critical state of newborns with perinatal lesions of the nervous system;

- Various forms of cerebral palsy.

Dosage regimen

The drug is introduced into / m.

Adults the drug is prescribed in a dose 10 mg 1 times / day for 10 days; Children weighing less than 20 kg – dose 0.5 mg / kg body weight, from body weight more 20 kg – dose 10 mg / day for 10 days.

If necessary, a second course through 3-6 Months.

Terms of preparation of the solution

The contents of the vial is dissolved in 1-2 ml 0.5% procaine solution (novocaine), water for injection or 0.9% sodium chloride solution.

Side effect

Data on side effects have been reported. The individual hypersensitivity to the drug.

Contraindications

- Pregnancy;

- Lactation (breast-feeding);

- Individual intolerance to the drug.

Pregnancy and lactation

The drug is contraindicated for use during pregnancy due to lack of clinical trial data.

If necessary, the appointment during lactation should stop breastfeeding (due to lack of clinical trial data).

Cautions

–

Overdose

Currently, cases of drug overdose were reported.

Drug Interactions

Drug Interactions drug Cortexin^® not disclosed.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

List B. The drug should be stored in a dry, dark place at a temperature of 2 ° to 20 ° C. Shelf life – 3 year.