Active material: Dextromethorphan, Paracetamol, Promethazine
When ATH: N02be71
CCF: The drug for the symptomatic treatment of acute respiratory diseases
ICD-10 codes (testimony): J06.9, J10
When CSF: 03.02.01.03
Manufacturer: GlaxoSmithKline Consumer Healthcare (Great Britain)
◊ Syrup dark green, clear, slightly viscous, with a characteristic smell of mint drug.
| 20 ml | |
| paracetamol | 1 g |
| promethazine hydrochloride | 20 mg |
| dextromethorphan gidrobromid | 15 mg |
Excipients: Dextrose liquid, ethanol 96%, macrogol 300, sodium cyclamate, Acesulfame K, sodium citrate sour, Sodium benzoate, flavored oil SL2677, Dyes (quinoline yellow E104, Patent Blue V), water demineralizovannaya.
100 мл – флаконы стеклянные с колпачком с защитой от детей и контролем первого вскрытия (1) в комплекте с мерным стаканчиком – пачки картонные.
160 мл – флаконы стеклянные с колпачком с защитой от детей и контролем первого вскрытия (1) в комплекте с мерным стаканчиком – пачки картонные.
Combined preparation for the symptomatic treatment of acute respiratory infections and colds.
Paracetamol okazыvaet zharoponizhayushtee and analygeziruyushtee action. Eliminates fever, reduces headache, pain in muscles and joints, that often accompany flu.
Прометазин – блокатор гистаминовых H1-receptors. Eliminates swelling of the mucous membrane of the nose and upper respiratory tract, restoring nasal breathing and reducing the amount of discharge from the nose.
Декстрометорфан – противокашлевое средство, that inhibits the excitability of the cough center and suppresses the cough of any origin.
Use of the drug helps to reduce the symptoms of acute respiratory infections and influenza, which in turn helps to improve sleep.
The data on the pharmacokinetics Coldrex® Knight does not have the.
To facilitate the ARI and influenza symptoms at night, including:
- Headache;
- Chills;
- Muscle pain;
- Sore throat;
- Rhinitis;
- Dry cough.
The drug is taken only 1 time / day, for the night, just before bedtime.
Adults (in patients t.ch.pozhilym) and children over the age of 12 years drug administered in a single dose 20 ml (4 spoon on 5 ml).
Children aged 6 to 12 years drug administered in a single dose 10 ml (2 spoon on 5 ml).
Allergic reactions: skin rash, itch, hives, angioedema.
Dermatological reactions: photosensitivity.
CNS: rarely - somnolence, dizziness, anxiety, dystaxia, blurred vision, disorientation.
From the hematopoietic system: rarely - anemia, thrombocytopenia.
From the digestive system: dry mouth.
Other: urinary retention, paresis of accommodation and bronchial (these side effects are temporary and disappear after drug withdrawal).
With prolonged use at high doses there is a risk of serious violations of the liver and kidneys.
- Liver disease;
- Kidney disease;
- Concomitant use of antidepressants, including MAO inhibitors and the period up to 14 days after their cancellation;
- Benign prostatic hypertrophy;
- Deficiency of glucose-6-fosfatdegidrogenazы;
- Blood disorders;
- Epilepsy;
- Children up to age 6 years;
- Hypersensitivity to the drug.
FROM caution should be prescribed to patients with asthma or other respiratory diseases, glaukomoj, urinary retention, cardiovascular diseases, while the application of indirect anticoagulants (warfarin), anxiolytic and hypnotic drugs.
Use the drug during pregnancy and breastfeeding should be after consulting a doctor.
The patient should be informed, if symptoms persist after 3 days of the drug, should stop taking it and consult a doctor.
The drug Coldrex® Knight should not be taken simultaneously with other medications, soderzhashtimi paracetamol, as well as alcoholic beverages.
Caution should be exercised when using other drugs on the day of a cold or drugs, soderzhashtih paracetamol. Do not take Coldrex® Knight at night, if the dose of paracetamol, Adopted during the day, already made 4 g total.
The drug should only be taken in recommended doses.
Effects on ability to drive vehicles and management mechanisms
Against the background of the drug may be sleepy. In this case, you must refrain from driving motor vehicles and other work, require high concentration and speed of psychomotor reactions.
Symptoms: pale skin, anorexia, nausea, vomiting, through 1-2 суток – признаки поражения печени, in severe cases develop liver failure and coma.
Treatment: gastric lavage within the first hour after ingestion, adsorbents (Activated carbon). A specific antidote for acetaminophen poisoning is NAC.
The drug enhances the effect of anticoagulants (coumarin derivatives), ethanol, hypnotics, anxiolytics and MAO inhibitors.
The simultaneous use of stimulants of microsomal oxidation in the liver (barbiturates, tricyclic antidepressants) It increases the risk of hepatotoxicity of paracetamol when administered in high doses.
Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxicity of paracetamol.
The drug can reduce the effectiveness of drugs urikozuricheskih.
Metoclopramide and domperidone increase, and cholestyramine reduces the absorption of paracetamol.
The drug is resolved to application as an agent Valium holidays.
The drug should be stored out of reach of children at or above 25 ° C. Shelf life - 2 year.
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