Ketoconazole (When ATH G01AF11)

When ATH:
G01AF11

Characteristic.

White powder;, soluble in acids in. Molecular weight 531,44.

Pharmacological action.
Antifungal, fungistatic, fungicidnoe, anti-androgenic.

Application.

Mycosis of the skin, hair and nails, caused by dermatophytes and / or yeast (dermatophytoses, onixomikoz, kandidoznaja paronixija, pityriasis versicolor, folliculitis, trihofitii), gastrointestinal mycosis, mycosis eyes, juccuya, seborrheic dermatitis, caused Pityrosporum ovale, systemic mycosis (candidiasis, parakokcidiomikoz, histoplasmosis, coccidiomycosis, blastomycosis), hrybkovыy sepsis, vaginal candidiasis (acute and chronic recurrent); mycoses in immunocompromised patients (prevention).

Contraindications.

Hypersensitivity, acute liver disease, pregnancy, lactation.

Restrictions apply.

Reduced function of the adrenal cortex and pituitary, severe renal and hepatic failure, concomitant use of potentially hepatotoxic drugs, childhood (to 2 years).

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

Decreased appetite, nausea, vomiting, diarrhea, abdominal pain, toxic hepatitis, increase in liver enzymes in the blood, jaundice, hepatitis (high mortality, the risk increases with the use of more 14 Nights), thrombocytopenia, headache, dizziness, drowsiness, paresthesia, photophobia, gynecomastia, decreased libido, impotence, oligospermatism, menstrual irregularities, hair loss, allergic reactions (hives, itching), arthralgia, fever; Local reactions - redness and irritation of the vaginal mucosa, itching of the vagina (suppozitorii); local skin irritation, burning, rash, contact dermatitis (cream, ointment); irritation, itching and burning of the skin, Increased oiliness or dryness of hair, hair loss (shampoo).

Cooperation.

It weakens the effect of amphotericin B. Incompatible with terfenadine, astemizolom, alcohol. Antacids, anticholinergics, H₂-blockers significantly reduce the absorption, rifampicin and isoniazid - concentration in the blood. It inhibits microsomal oxidation both prescribed drugs and increases their concentration, enhances the toxicity fenitonina. It reduces the stimulating effect on the adrenal corticotropin. Co-administration of oral contraceptives with low hormone levels cause breakthrough bleeding.

Dosing and Administration.

Inside, while eating, adults and children weighing more than 30 kg - for 200 mg 1 once a day, the ineffectiveness - 400 mg 1 once a day; children weighing from 15 to 30 kg - 100 mg 1 time. When prophylactic use in immunocompromised patients prescribed for adults 400 mg / day, Children - 4-8 mg / kg / day. Outwardly, cream or ointment applied to the affected areas 1 once a day. The shampoo is applied to the affected skin and hair, then after 3-5 minutes wash off with water. Intravaginal - By 1 supp. within 3-5 days. Treatment continues for at least a week after the disappearance of all symptoms of the disease.

Cooperation