Camiri

Active material: Doksazozin
When ATH: C02CA04
CCF: Alpha₁-adrenoblokator. Antihypertensive drugs. Preparation, used in violation of urination in benign prostate hyperplasia glands
ICD-10 codes (testimony): I10, N40
When CSF: 01.01.02.02
Manufacturer: KRKA d.d. (Slovenia)

Pharmaceutical form, composition and packaging

Pills white, round, slightly biconcave, with beveled edges.

Excipients: microcrystalline cellulose, sodium starch glycolate, magnesium stearate, sodium lauryl, lactose monohydrate.

10 PC. – packings Valium planimetric (2) – packs cardboard.
10 PC. – packings Valium planimetric (3) – packs cardboard.

Pills white, round, flat, with beveled edges and a notch (Valium) on one side.

Excipients: microcrystalline cellulose, sodium starch glycolate, magnesium stearate, sodium lauryl, lactose monohydrate.

10 PC. – packings Valium planimetric (2) – packs cardboard.
10 PC. – packings Valium planimetric (3) – packs cardboard.

Pills white, round, flat, with beveled edges and a notch (Valium) on one side.

Excipients: microcrystalline cellulose, sodium starch glycolate, magnesium stearate, sodium lauryl, lactose monohydrate.

10 PC. – packings Valium planimetric (2) – packs cardboard.
10 PC. – packings Valium planimetric (3) – packs cardboard.

Pharmacological action

Selective antagonist of α₁-adrenoreceptorov. It was the expansion of peripheral blood vessels, which leads to a decrease in peripheral vascular resistance and reduction in blood pressure. Effect of the drug on cardiac function and is marginally transitory nature. Doxazosin lowers total cholesterol, LDL-C and triglycerides, increases HDL-cholesterol content in blood serum. Thus, drug helps prevent the development of atherosclerosis and coronary heart disease. Doxazosin has a neutral or normalizing effect on insulin and blood glucose, so the product can be used in patients with diabetes. It inhibits platelet aggregation. In long-term treatment of doxazosin reduces the mass of the left ventricle.

Doxazosin prevents the smooth muscle of the upper urethra and the muscles of the prostate, that surround the urethra. Relaxation of these muscles leads to relief of urination, which significantly reduces the unpleasant symptoms, observed in benign prostatic hyperplasia. The therapeutic effect is within the first 2 weeks of treatment and increases with subsequent therapy. Action doxazosin on normal blood pressure slightly.

Camiri can be used in patients with renal insufficiency, chronic obstructive pulmonary disease, peripheral arterial disease, and gout.

In single dose duration of Camiri 24 no. Action on blood pressure is most pronounced for 2-6 h after dosing. The maximum effect is achieved after a few weeks of regular reception. If the therapeutic effect is not enough, patients can be prescribed other antihypertensive agents: beta-blockers, Diuretic, calcium channel blockers and ACE inhibitors.

Pharmacokinetics

Absorption

After oral administration, doxazosin is well absorbed from the gastrointestinal tract. C_max achieved through 1.5-3 no.

Distribution

Doxazosin is almost completely bound to plasma proteins.

Metabolism

It is metabolized in the liver.

Deduction

T_1/2 is 16-22 no.

Excreted in the feces as metabolites. Less 10% the dose is excreted in the urine.

Testimony

- The treatment of mild to moderate hypertension (as monotherapy or in combination with other antihypertensive drugs);

- Symptomatic treatment of benign prostatic hyperplasia.

Dosage regimen

Set individually and adjusted depending on the effectiveness of treatment and / or development of side effects.

At hypertension initial dose of doxazosin is 1 mg / day. The first dose should be taken at night before bedtime. Depending on the effect of the drug on blood pressure, dose can be gradually increased at intervals of 1-2 weeks before 2 mg, 4 mg, 8 mg 1 time / day. Usually, average daily doses ranging from 2 mg 8 mg. The maximum daily dose is 16 mg.

At benign prostatic hyperplasia in patients with normal blood pressure starting dose is 1 mg / day. The first dose should be taken at night before bedtime. Depending on the response to treatment, dose can be gradually increased at intervals of 1-2 weeks before 2 mg, 4 mg, 8 mg 1 time / day. The average daily dose is from 2 mg 4 mg. The maximum daily dose – 8 mg.

At benign prostatic hyperplasia in patients with hypertension drug administered in the same doses, as only patients with hypertension.

In Patients with liver failure the drug is used at lower doses (due to slow metabolism doxazosin).

The drug can be taken before, during or after meals.

If the drug at the usual time passed, it should be as soon as possible to take this dose. If it is time for the next dose, you should only take it, not doubling the dose. It is important to take the drug regularly. If the patient is taking the drug for several days, the new therapeutic course should start with the lowest dose.

Side effect

Cardio-vascular system: at the beginning of treatment and with increasing doses of the drug may be a tendency to fainting (especially when changing from a lying or sitting position to a standing position), dizziness, headache. These effects disappear on their own, but if they are severe or persist for a long time, the dose should be reduced or stop taking the drug; in some cases, possible tachycardia, palpitations.

Rarely (connection with the reception of doxazosin is not clearly established) – worsening of angina, myocardial infarction, cerebrovascular stroke, abnormal heart rhythm.

From the central and peripheral nervous system: You may be feeling tired, drowsiness, muscular weakness.

From the digestive system: possible nausea; rarely – violations of liver function tests, cholestasis, hepatitis.

The respiratory system: possible bronchitis, breathlessness, a feeling of nasal congestion, nasal discharge.

From the blood coagulation system: rarely – thrombocytopenia, purpura, nosebleeds.

From the urinary system: rarely – hematuria; in some cases – urinary incontinence.

Other: possible swelling of the ankles and legs, flu-like symptoms; rarely – skin rash; in a few cases (connection with the reception of doxazosin is not clearly established) – impotence.

Contraindications

- Obstruction of the digestive tract or esophagus;

- Narrowing of the gastrointestinal tract of any;

- Children's age;

- Hypersensitivity to doxazosin and other ingredients;

- Increased sensitivity to other quinazoline derivatives (prazosin, terazosin).

Pregnancy and lactation

Camiri Application during pregnancy is possible only for health reasons, when the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

If necessary, use during lactation should stop breastfeeding, tk. Camiri safety in infants is not installed.

Cautions

Doxazosin has no effect on the concentration of PSA (Prostate specific antigen).

Upon receipt of Camiri, especially the first dose, possible orthostatic hypotension (fainting). To avoid such phenomena, treatment should be initiated with a dose 1 mg in the evening before going to bed. The dosage should be gradually increased at intervals of 1-2 of the week. Patients should be warned of the possibility of orthostatic hypotension and Share gently rising from a lying or sitting position. This is especially true for the elderly and the sick, simultaneously receiving other antihypertensive drugs or diuretics. To use caution in combination with other antihypertensive agents, especially at the beginning of treatment, tk. may increase the antihypertensive effect.

Doxazosin is not recommended in patients with arterial hypertension. Before therapy for patients with symptoms, caused by benign prostatic hyperplasia, necessary to urological examination.

Patients with hepatic insufficiency doxazosin is metabolized more slowly, therefore increasing the dose of the drug should be made with caution.

Use in Pediatrics

Safety and effectiveness in pediatric patients has not been established, and the drug is not recommended for children.

Effects on ability to drive vehicles and management mechanisms

At the beginning of treatment and when changing Kamirenom dose possible excessive reduction of blood pressure, which may be accompanied by dizziness. Therefore, in such cases, it is not recommended to drive and engage in potentially hazardous activities.

Overdose

Symptoms: Excessive hypotension, dizziness, possible fainting.

Treatment: In most cases, it dose reduction or temporary interruption of therapy. The patient should be given the supine position with a low headboard and legs slightly raised. Do not induce vomiting. For removing unabsorbed drug from the gastrointestinal tract should be performed gastric lavage, assign activated carbon, laxative. Назначают агонисты a-адренорецепторов (eg, noradrenaline). Hemodialysis nyeeffyektivyen (as doxazosin almost completely bound to plasma proteins).

Drug Interactions

With simultaneous use of Camiri with other antihypertensive agents (блокаторами b-адренорецепторов, Diuretics, calcium channel blockers, ACE inhibitors) there is a growing anti-hypertensive effect (the use of such a combination is possible, However, caution should be exercised, especially at the beginning of treatment).

With simultaneous use of Camiri with nitrates, anesthetics, tricyclic antidepressants, and ethanol may enhance the antihypertensive effect (the use of such a combination is possible, However, caution should be exercised, especially at the beginning of treatment).

In an application with drugs Camiri, It affects the rate of metabolism in the liver, possibly slowing or accelerating metabolic doxazosin (should be used with caution).

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

The drug should be stored at a temperature no higher than 30 ° C. Shelf life – 3 year.