Izoprinozin

Active material: Inosine pranobex
When ATH: J05AX05
CCF: Immunostimulatory drug
ICD-10 codes (testimony): A60, A63.0, A81.1, B00, B01, B02, B05, G04
When CSF: 09.01.05.03
Manufacturer: YOUR Pharmaceutical Industries Ltd. (Israel)

Pharmaceutical form, composition and packaging

Pills oblong, white or nearly white, with Valium on one side.

Excipients: magnesium stearate, povidone, starch, mannitol.

10 PC. – blisters (5) – packs cardboard.

Pharmacological action

Immunostimulatory drug with antiviral action.

The pharmacological action of the complex is determined by the presence of inosine; the second component increases its availability to lymphocytes.

Isoprinosine stimulates biochemical processes in macrophages, increases the production of interleukin, increased synthesis of antibodies, enhances the proliferation of T-lymphocytes, T-helpers, natural killer cells. It stimulates the chemotactic and phagocytic activity of monocytes, macrophages and polymorphonuclear cells. Isoprinosine inhibits the replication of DNA and RNA viruses by binding with ribosome cells and changes its stereochemical structure.

Pharmacokinetics

Absorption

After ingestion well absorbed from the gastrointestinal tract.

Metabolism and excretion

Inosine is rapidly metabolized by cycle, typical of purine nucleotides, to form uric acid. Return with urine unchanged and as metabolites within 48 no. Cumulation is not observed.

Testimony

- Immunodeficiency, accompanied by the development of diseases, caused by the Herpes simplex virus, Varicella zoster, measles virus, Epstein-Barr virus, as well as the development of subacute sclerosing panencephalitis and acute viral encephalitis;

- Genital warts.

Dosage regimen

Tablets are taken after a meal, with a little water.

The recommended daily dose Adults and children is 50 mg / kg body weight 3-4 admission, that is an average adult – 6-8 tab. / day, for children – 1 tab. on 10 kg body weight per day. At acute viral infections duration of treatment is 5-10 days, after reducing the symptoms, treatment should continue even 1-2 day. At recurrent viral infections the drug should be continued throughout 1-2 weeks after the symptoms disappear.

At serious infectious diseases in Adult and children izoprinozin dose may be increased to 100 mg / kg / day 4-6 receptions for 7-10 days. This is followed by a break for 8 days and optionally – conduct repeated course for 7-10 days.

If necessary, the dose and duration of continuous rate can be increased at obligatory observance of a break in taking the drug during 8 days. Long-term treatment is carried out under medical supervision.

At genital warts the drug is prescribed as monotherapy or in combination with other conventional treatment regimens for 2 tab. 3 times / day for 5 days, Further 3x repetition rate of said at intervals 1 Months.

In appointing the drug parties Seniors correction dosing regime is not required.

Side effect

Metabolism: transient increase in uric acid in the serum and urine (normalized during treatment or within a few days after the end).

From the digestive system: nausea, vomiting, epigastric pain, constipation, diarrhea, a temporary increase in liver transaminases.

Dermatological reactions: xerosis.

Allergic reactions: skin rash, itch.

CNS: headache, dizziness, nervousness, sleep disorders (drowsiness, insomnia), slackness, a feeling of fatigue.

Other: polyuria, joint pain, worsening of gout, weakness.

Contraindications

- Urolithiasis disease;

- Gout;

- Arrhythmia;

- Chronic renal failure;

- Hypersensitivity to the drug.

Pregnancy and lactation

Security izoprinozin use during pregnancy and lactation has not been established, therefore, use of the drug is not recommended.

Cautions

Monitoring of laboratory parameters

After 2 izoprinozin weeks of treatment is recommended to control the content of uric acid in the serum and urine. After 4 weeks of every month it is advisable to carry out the control functions of the liver and kidneys (Activity of transaminases, creatinine level, Uric acid).

Effects on ability to drive vehicles and management mechanisms

No specific contraindications against driving a vehicle or control machines and mechanisms.

Overdose

Data on overdose izoprinozin not provided.

Drug Interactions

With simultaneous use of immunosuppressive drugs may reduce the effectiveness of izoprinozin.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

List B. The drug should be stored in a dry, protected from light, inaccessible to children at temperature from 15 ° to 25 ° C. Shelf life – 5 years.