Yoheksol

When ATH:
V08AB02

Characteristic.

Iodine-containing nonionic radiopaque agent. The sterile aqueous solution of a colorless or pale yellow, It has a pH 6,8-7,6, osmolality in 1,1-3 times above the plasma osmolality.

Pharmacological action.
Rentgenocontrast.

Application.

Angiokardiografija (ventriculography, Selective coronary arteriography), aortography (including a study of the root and the aortic arch, the ascending aorta, the abdominal aorta and its branches), pulmonary angiography, heads, Neck, of the brain, abdomen, kidney; study of collateral circulation, venography, descending urography, myelography (lumbar, chest, Neck, general), increasing resolution computed tomography (CT) heads, torso and abdomen, CT myelography, cisternografii, ventriculography, Endoscopic retrograde pankreatoholangiorentgenografii, arthrography, hysterosalpingography, cistouretrografii, gerniografii, GI radiography.

Contraindications.

Hypersensitivity (incl. to other iodine-containing drugs), local or systemic infection, pregnancy.

Restrictions apply.

Epilepsy, degidratatsiya, severe cardiovascular diseases, decompensated heart failure, pulmonary hypertension, severe renal dysfunction and liver, Saint Martin's evil, multiple sclerosis, mnozhestvennaya myeloma and Others paraproteinemicheskie gemoblastozы, pheochromocytoma, thyrotoxicosis, drepanocytemia, Buerger's disease, acute thrombophlebitis, trombofilicescie state, allergic diseases (bronchial asthma, pollen disease, alimentary allergy), expressed atherosclerosis, advanced age.

Side effects.

Feeling the heat, heart rhythm disturbances, chest pain, gipotenziya, heart failure, bradycardia / tachycardia, asistolija, headache, dizziness, back pain, neck, constraint, neuralgia, paresthesia, convulsions, decreased appetite, taste disturbance, nausea, vomiting, hypotension / hypertension, Sweating, weakness, photophobia, allergic reactions (fever, chills, profuse diarrhea, itching, rashes on the type of urticaria, nasal congestion, breathlessness, Guillain-Barré Syndrome), pain at the injection site.

Cooperation.

Incompatible (intrathecal) with corticosteroids. Pharmaceutical incompatible (in the same syringe) with antihistamines and many others. preparations. Phenothiazine derivatives, etc.. neuroleptics, MAO inhibitors, tricyclic antidepressants, CNS stimulants, analeptiki, antipsychotic drugs reduce the seizure threshold and increase the risk of seizures. Beta-blockers and other antihypertensive drugs increases the risk of hypotension. Enhances nephrotoxic properties, etc.. preparations.

Overdose.

Symptoms: cyanosis, bradycardia, Acidosis, pulmonary hemorrhage, cardiac arrest, insomnia or drowsiness, weakness, fatiguability, stupor, convulsions, coma, disorders of mental activity: hallucinations, depersonalization, fear, disorientation, ekholaliya, depression, amnesia, psychosis, amblyopia, diplopia, photophobia, gipesteziya, visual, hearing or speech disorders, EEG changes, meningism, hyperreflexia or areflexia, hemiplegia, paralysis, quadriplegia, tremor, bleeding in the brain.

Treatment: monitoring and maintenance of vital functions, symptomatic therapy.

Dosing and Administration.

B /, B / A, endolyumbalno, suʙaraxnoidalьno, intracisternally, orally. The mode set individually depending on the type of research, used methods and techniques of doing research, age and body weight of the patient, general condition of the patient, cardiac output. Recommended average concentrations of iodine in / in the introduction of 240, 300 or 350 mg / ml, When b/a is 140, 240, 300 or 350 mg / ml, When intratekal'nom- 180, 240 or 300 mg / ml, vnutripolostnom — 240 or 300 mg / ml, oral- 180, 240, 300 or 350 mg / ml.

To minimize the risk of adverse reactions the total dose of iodine should not exceed 3 g.

Precautions.

Diagnostic procedures using iohexol can be carried out only in a hospital to the intensive care unit specially trained personnel with sufficient experience in conducting such investigations; desirably observed for 30-60 min after drug administration. You must cancel the neirolepticalkie drugs at least 48 hours before the mielografii. Before the introduction of injectable solution should be carefully considered for the presence of inclusions and color changes. Caution should be used when iohexol danger of dehydration and acute renal failure, cardiovascular diseases, diabetes, in elderly patients with kidney disease (possible osmotic diuretic effect); prior to the study, patients of these categories must be sufficiently hydrated. Be wary appoint elderly and children because of the high risk of severe adverse reactions (incl. aseptic meningitis) and opportunities to strengthen dehydration. Avoid carrying myelography epilepsy and increased convulsive readiness. We do not recommend re-myelography immediately after the failed predecessor (the risk of overdose); safest repetition of studies in 5-7 days. The caution administered in / in patients with hematological malignancies paraproteinemic (risk of acute irreversible renal failure as a result of precipitation in the renal tubules paraprotein). When carrying out a careful angiocardiography dose selection for patients with symptoms of right heart failure and pulmonary hypertension (risk expressed hemodynamic changes in contact with the drug in the right heart). Performing angiography Segment aortoiliac obstruction and / or femoral artery, increasing the pressure in the abdominal cavity, hypotension and hypertension requires careful observation at the time of the study due to the high risk of neurological complications, including paraplegia.

Cautions.

It may distort the results of radioisotope studies of thyroid function for several weeks after administration.