Active material: Indapamid
When ATH: C03BA11
CCF: Diuretic. Antihypertensive drugs
When CSF: 01.08.02.02
Manufacturer: HEMOFARM A.D. (Serbia)
Pills long-acting, Film-coated from white to almost white, round, lenticular.
| 1 tab. | |
| indapamid | 1.5 mg |
[Ring] lactose monohydrate, gipromelloza, magnesium stearate, Colloidal anhydrous silica.
The composition of the shell: Titanium dioxide (E171), magnesium stearate, glycerol, macrogol 6000.
10 PC. – блистеры (3) – пачки картонные.
Pills, coated (film) white, lenticular.
| 1 tab. | |
| indapamid | 2.5 mg |
Excipients: microcrystalline cellulose, starch 1500, colloidal silicon dioxide (aэrosyl), magnesium stearate, opadraj II.
10 PC. – упаковки ячейковые контурные (1) – пачки картонные.
10 PC. – упаковки ячейковые контурные (2) – пачки картонные.
10 PC. – упаковки ячейковые контурные (3) – пачки картонные.
10 PC. – упаковки ячейковые контурные (4) – пачки картонные.
10 PC. – упаковки ячейковые контурные (5) – пачки картонные.
Pills, Film-coated white, round, lenticular.
| 1 tab. | |
| indapamid | 2.5 mg |
[Ring] lactose monohydrate, povidone K-30, krospovydon, magnesium stearate, sodium lauryl, talc.
The composition of the shell:
gipromelloza, macrogol 6000, talc, Titanium dioxide (E171).10 PC. – блистеры (3) – пачки картонные.
Pills, Film-coated white, round, lenticular.
| 1 tab. | |
| indapamid | 2.5 mg |
Excipients: lactose monohydrate, povidone K-30, krospovydon, magnesium stearate, sodium lauryl, talc.
The composition of the shell: gipromelloza, macrogol 6000, talc, Titanium dioxide (E171).
10 PC. – блистеры (3) – пачки картонные.
Tiazidopodobnый diuretic, antihypertensive tool. Causes downgrading tone smooth muscles of the arteries, reduction in systemic vascular resistance, also has moderate saluretičeskoj activity, resulting from the violation of reabsorption of sodium ions, chlorine and water in korticalnom segment hinges Genle and proximal tubular izvitom nefrona. Reducing ROUND due to several mechanisms: the decrease in sensitivity of vascular wall to norarenalino and Angiotensin II; increased synthesis of prostaglandins, possessing vazodilatiruta activity; oppression of the influx of calcium ions in gladkomyshechne vascular wall elements. At therapeutic doses, has practically no effect on the lipid and carbohydrate metabolism.
Gipotenzivny effect manifests itself only when initially increased AD, develops by the end of the first week and reaches its maximum at 3 months of systematic reception.
Once inside quickly and completely absorbed from the gastrointestinal tract, Cmax plasma achieved through 1-2 no. Plasma protein binding is 79%. Widely distributed in the body. Not accumulates.
T1/2 is 18 no. Report the news, mainly in the form of metabolites, 5% - Unchanged.
Arterial hypertension; delay sodium and water in chronic heart failure.
Is the inside of 2.5 mg 1 time / day (morning). The lack of symptoms gipotenzivnogo effect after 2 weeks of treatment dose to 5-7.5 mg / day.
The maximum dose: 10 mg / day 2 admission (in the first half of the day).
From the digestive system: nausea, discomfort or pain in the epigastria.
CNS: weakness, fatiguability, dizziness, nervousness.
Cardio-vascular system: orthostatic hypotension.
Metabolism: kaliopenia, hyperuricemia, giperglikemiâ, giponatriemiya, chloropenia.
Allergic reactions: cutaneous manifestations.
Acute violation of cerebral circulation, expressed by the human kidney and / or liver, severe diabetes and gout, hypersensitivity to indapamidu.
Adequate and well-controlled studies safety of indapamida in pregnancy and lactation has not been. Use in this category of patients is not recommended.
To apply caution in patients with diabetes mellitus (requires control of glucose levels, especially in the presence of hypokalemia), gout (Perhaps an increase in the number of attacks), in patients with a history of allergic reactions to derivative sulfonamidov.
During treatment, it is necessary to monitor the level of electrolytes in the blood plasma (potassium, sodium, calcium).
While applying SCS, tetrakozaktida for systemic use is reduced because of the delay in hypotensive effect of water and sodium ions under the influence of SCS.
Together with the use of ACE inhibitors increases the risk of hyponatremia.
In an application with NSAIDs (for systemic use) possible reduced action of hypotensive indapamida. With a significant loss of fluid may develop acute renal failure (because of the sharp decline in glomerular filtration rate).
Together with the use of drugs calcium may develop hypercalcemia due to decreasing excretion of calcium ions with urine.
Together with the use of cardiac glycosides, korticosteroidami increased risk gipokaliemii.
With simultaneous use of funds, which can cause hypokalemia (amphotericin B, glitches- and mineralocorticoid, tetracosactide, laxatives, stimulating intestinal peristalsis) increases the risk of developing gipokaliemii.
With simultaneous use of tricyclic antidepressants (incl. with imipraminom) amplified gipotenzivne effect and increased risk of orthostatic hypotension (additive effect).
If you are applying with astemizolom, bepridil, Erythromycin (I /), pentamidine, sultoprydom, terfenadine, vynkamynom, xinidinom, dizopiramidom, amiodarone, bretilia tozilatom, соталолом возникает риск развития аритмии типа “пируэт”.
Together with the application baklofenom amplified gipotenzivny effect.
Together with the use of galofantrinom increases the likelihood of heart rhythm disorders (incl. желудочковой аритмии типа “пируэт”).
Together with the use of lithium carbonate increases the risk of toxic effects of lithium on the background of lowering its renal clearance.
Together with the use of metformin may cause molernkislogo azidoza, which is connected, apparently, with the development of functional renal failure, due to the action of diuretics (mostly loop).
Together with the use of ziklosporinom possible increase of creatinine in the blood plasma, observed that even with normal water and sodium ions.
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