Immunoglobulin antitimotsitarnyi

When ATH:
L04AA04

Pharmacological action.

Immunosuppressant, the effect of which is caused by the blockade antigenchuvstvitelnyh determinants of immune cells and the partial destruction of lymphocytes.

Pharmacokinetics

Data not provided

Testimony

- Prevention of graft rejection in patients with allogenic transplant of organs and tissues (kidneys, heart, pancreas, liver);

- Aplasticheskaya anemia.

Dosage regimen

Antilimfolin introduced into / in the drip, with speed 20 drop / min. The solution formulation is prepared ex tempore on 0.9% sodium chloride or 5% dextrose. Single (from 2 to 5 mg / kg) and the total dose, the frequency of administration are determined individually for each patient (depend on the grafted tissue, degree gistonesovmestimosti recipient and donor tissue graft and the sensitivity of the patient to the drug) and extent are established by reducing the number of lymphocytes and number of rosette-forming cells through 4 hours after the first injection (compared with baseline) and general condition of the patient (incl. the number of leukocytes, leukocyte, platelet count).

Side effect

Conditioned by the specific action of the drug: fervescence to 37.5-38 ° C, chills, malaise (developed by 2 hours after injection and disappear through 4-5 no).

The development of infections (It recommended for use in combination with antibacterial agents, taking into account the patient's condition and the extent of inhibition of cellular and humoral immunity).

With long-term use of the drug – geterosensibilizatsiya to proteins of blood serum of goats (recommended desensitizing therapy).

Contraindications

- Hypersensitivity (incl. a goat or rabbit proteins);

- Acute infectious diseases (incl. Viral, Bacterial and fungal);

- Sepsis;

- Immunosuppression;

- Pregnancy (the expected or actual);

- Lactation.

Pregnancy and lactation

Contraindicated during pregnancy and lactation.

Cautions

It applies only in a hospital and under medical supervision.

In the case of geterosensibilizatsii to proteins of blood serum of goats for further immunosuppressive therapy should be used anti-thymocyte immunoglobulin, obtained from blood serum, etc.. species.

In applying the drug should be CBC, tk. administration of the drug leads to specific changes in the cellular composition of blood through 4-5 no: reducing the number of lymphocytes 20-70% starting from, neutrophilia with a shift to the left. The degree of reduction in the number of lymphocytes can be used as a criterion for the adequacy of the dose. The best option should be considered reducing the number of lymphocytes 30-50% starting from.

Drug Interactions

The introduction of anti-thymocyte immunoglobulins in the coming 1.5-3 months after vaccination with live attenuated vaccines (Measles, Rubella, mumps and chicken pox), It increases the risk of generalized systemic infections (which can be fatal).

Immunosuppressive – the risk of severe immunosuppression. Pharmaceutically compatible only with isotonic sodium chloride solution, and dextrose.